QQ客服 官方微博 反馈留言

浏览/检索结果: 共22条，第1-10条 帮助 限定条件 发表日期：2019    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Discovery and biological evaluation of vinylsulfonamide derivatives as highly potent, covalent TEAD autopalmitoylation inhibitors 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 184, 页码: 15 作者:  Lu, Wenchao;  Wang, Jun;  Li, Yong;  Tao, Hongru;  Xiong, Huan 收藏  |  浏览/下载：98/0  |  提交时间：2020/07/01 Hippo pathway  TEAD transcription factor  Covalent inhibitor  Palmitoylation inhibitor   A Novel Allosteric Inhibitor of Phosphoglycerate Mutase 1 Suppresses Growth and Metastasis of Non-Small-Cell Lung Cancer 期刊论文 CELL METABOLISM, 2019, 卷号: 30, 期号: 6, 页码: 1107-+ 作者:  Huang, Ke;  Liang, Qian;  Zhou, Ye;  Jiang, Lu-lu;  Gu, Wei-ming 收藏  |  浏览/下载：79/0  |  提交时间：2020/07/01 Ruthenium(II)-Catalyzed C-H Acylmethylation between (Hetero)arenes and alpha-Cl Ketones/Sulfoxonium Ylides 期刊论文 JOURNAL OF ORGANIC CHEMISTRY, 2019, 卷号: 84, 期号: 21, 页码: 13262-13275 作者:  Li, Huihui;  Wu, Chenglin;  Liu, Hong;  Wang, Jiang 收藏  |  浏览/下载：21/0  |  提交时间：2020/07/01 C10ORF12 modulates PRC2 histone methyltransferase activity and H3K27me3 levels 期刊论文 ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 11, 页码: 1457-1465 作者:  Shi, Yi;  Ma, Hong-lei;  Zhuang, You-wen;  Wang, Xiao-xi;  Jiang, Yi 收藏  |  浏览/下载：37/0  |  提交时间：2020/07/01 PRC2  C10ORF12  H3K27me3  histone methyltransferase  epigenetic regulation  histone modification   Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives (THPBs) as proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators for the treatment of hyperlipidemia 期刊论文 ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 6, 页码: 1216-1230 作者:  Wu, Chenglin;  Xi, Cong;  Tong, Junhua;  Zhao, Jing;  Jiang, Hualiang 收藏  |  浏览/下载：51/0  |  提交时间：2020/07/01 PCSK9  Tetrahydroprotoberberine derivatives  Low-density lipoprotein cholesterol  Lipid-lowering  PCSK9 expression  Low-density lipoprotein receptor  Total cholesterol  Hyperlipidemia hamster   Design, synthesis and biological evaluation of 6-deoxy O-spiroketal C-arylglucosides as novel renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 180, 页码: 398-416 作者:  Wang, Yibing;  Lou, Yang;  Wang, Jiang;  Li, Dan;  Chen, Hui 收藏  |  浏览/下载：21/0  |  提交时间：2020/07/01 SGLT2 inhibitors  Diabetes  Sugar modification  Structure-activity relationship  Urinary glucose excretion  Oral glucose tolerance   Small molecule IVQ, as a prodrug of gluconeogenesis inhibitor QVO, efficiently ameliorates glucose homeostasis in type 2 diabetic mice 期刊论文 ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 9, 页码: 1193-1204 作者:  Zhou, Ting-ting;  Zhao, Tong;  Ma, Fei;  Zhang, Yi-nan;  Jiang, Jing 收藏  |  浏览/下载：27/0  |  提交时间：2020/07/01 type 2 diabetes mellitus  hepatic gluconeogenesis  AMPK signaling pathway  (E)-3-(2-(quinoline-4-yl)vinyl)-1H-indol-6-ol (QVO)  4-[2-(1H-indol-3-yl)vinyl]quinoline (IVQ)  prodrug   New New cytotoxic ergostane-type sterols from the Chinese soft coral Sinularia sp. 期刊论文 STEROIDS, 2019, 卷号: 149, 页码: 5 作者:  Jiang, Cheng-Shi;  Ru, Tong;  Huan, Xia-Juan;  Miao, Ze-Hong;  Guo, Yue-Wei 收藏  |  浏览/下载：44/0  |  提交时间：2020/07/01 Soft coral  Sinularia sp.  Ergostane  Antiproliferative activity  Apoptosis   Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 16, 页码: 7473-7488 作者:  Wang, Yulan;  Dai, Yang;  Wu, Xiaowei;  Li, Fei;  Liu, Bo 收藏  |  浏览/下载：23/0  |  提交时间：2020/07/01 SNORD89 promotes stemness phenotype of ovarian cancer cells by regulating Notch1-c-Myc pathway 期刊论文 JOURNAL OF TRANSLATIONAL MEDICINE, 2019, 卷号: 17, 期号: 1, 页码: 15 作者:  Zhu, Wenjing;  Niu, Jumin;  He, Miao;  Zhang, Liwen;  Lv, Xuemei 收藏  |  浏览/下载：98/0  |  提交时间：2020/07/01 Ovarian cancer stem cells  TCGA  SNORNAs  SNORD89