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浏览/检索结果: 共15条，第1-10条 帮助 限定条件 发表日期：2018    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Discovery and optimization of a series of 3-substituted indazole derivatives as multi-target kinase inhibitors for the treatment of lung squamous cell carcinoma 期刊论文 European journal of medicinal chemistry, 2018, 卷号: 163, 页码: 671-689 作者:  Wang, Qi;  Dai, Yang;  Ji, Yinchun;  Shi, Huanyu;  Guo, Zuhao 收藏  |  浏览/下载：91/0  |  提交时间：2019/01/08 The secretome engages STAT3 to favor a cytokine-rich microenvironment in mediating acquired resistance to FGFR inhibitors 期刊论文 Molecular cancer therapeutics, 2018, 卷号: 145, 页码: 817-842 作者:  Wang, Xinyi;  Ai, Jing;  Liu, Hongyan;  Peng, Xia;  Chen, Hui 收藏  |  浏览/下载：138/0  |  提交时间：2019/01/08 1,4-Diaryl-2-azetidinone  Combretastatin A-4  Tubulin polymerization  Antitumor   Rational design of 5-((1H-imidazol-1-yl)methyl)quinolin-8-ol derivatives as novel bromodomain-containing protein 4 inhibitors 期刊论文 European journal of medicinal chemistry, 2018, 卷号: 163, 页码: 281-294 作者:  Xing, Jing;  Zhang, Rukang;  Jiang, Xiangrui;  Hu, Tianwen;  Wang, Xinjun 收藏  |  浏览/下载：90/0  |  提交时间：2019/01/08 Andrographolide Sulfonate Attenuates Acute Lung Injury by Reducing Expression of Myeloperoxidase and Neutrophil-Derived Proteases in Mice 期刊论文 FRONTIERS IN PHYSIOLOGY, 2018, 卷号: 9 作者:  Gao, Fei;  Liu, Xing;  Shen, Ziying;  Jia, Xiaohui;  He, Han 收藏  |  浏览/下载：51/0  |  提交时间：2019/01/08 andrographolide sulfonate  acute lung injury  iTRAQ  quantitative proteomics  immunohistochemistry   Magnesium lithospermate B improves the gut microbiome and bile acid metabolic profiles in a mouse model of diabetic nephropathy 期刊论文 Acta pharmacologica Sinica, 2018 作者:  Zhao, Jing;  Zhang, Qing-Li;  Shen, Jian-Hua;  Wang, Kai;  Liu, Jia 收藏  |  浏览/下载：20/0  |  提交时间：2019/01/08 Discovery and structure-activity relationships study of thieno[2,3-b] pyridine analogues as hepatic gluconeogenesis inhibitors 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 152, 页码: 307-317 作者:  Ma, Fei;  Liu, Jian;  Zhou, Tingting;  Lei, Min;  Chen, Jing 收藏  |  浏览/下载：82/0  |  提交时间：2019/01/08 Thienol2,3-b]pyridine derivatives  Structure-activity relationships (SARs)  Hepatic gluconeogenesis  Type 2 diabetes mellitus (T2DM)   TSPA as a novel ATF6 alpha translocation inducer efficiently ameliorates insulin sensitivity restoration and glucose homeostasis in db/db mice 期刊论文 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 卷号: 499, 期号: 4, 页码: 948-953 作者:  Zhou, Tingting;  Cheng, Yanhua;  Yan, Wenzhong;  Shi, Xiaofan;  Xu, Xin 收藏  |  浏览/下载：35/0  |  提交时间：2019/01/08 ATF6 alpha  ER stress  insulin resistance  TSPA  T2DM   Preclinical Evaluation of SCC244 (Glumetinib), a Novel, Potent, and Highly Selective Inhibitor of c-Met in MET-dependent Cancer Models 期刊论文 MOLECULAR CANCER THERAPEUTICS, 2018, 卷号: 17, 期号: 4, 页码: 751-762 作者:  Ai, Jing;  Chen, Yi;  Peng, Xia;  Ji, Yinchun;  Xi, Yong 收藏  |  浏览/下载：58/0  |  提交时间：2019/01/08 Structure-Based Discovery of a Series of 5H-Pyrrolo[2,3-b]pyrazine FGFR Kinase Inhibitors 期刊论文 MOLECULES, 2018, 卷号: 23, 期号: 3 作者:  Jiang, Alan;  Liu, Qiufeng;  Wang, Ruifeng;  Wei, Peng;  Dai, Yang 收藏  |  浏览/下载：38/0  |  提交时间：2019/01/08 cancer  FGFR  kinase inhibitor  pyrrolo[2,3-b]pyrazine   New microtubulin inhibitor MT189 suppresses angiogenesis via the JNK-VEGF/VEGFR2 signaling axis 期刊论文 CANCER LETTERS, 2018, 卷号: 416, 页码: 57-65 作者:  Xu, Lin;  Wang, Wei;  Meng, Tao;  Ma, Lan-Ping;  Tong, Lin-Jiang 收藏  |  浏览/下载：22/0  |  提交时间：2019/01/08 MT189  Microtubulin inhibitor  VEGF  Src  JNK  Cell adhesion