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科研机构
上海药物研究所 [9]
内容类型
期刊论文 [9]
发表日期
2018 [9]
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发表日期:2018
专题:上海药物研究所
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18β-Glycyrrhetinic acid protects against alpha-naphthylisothiocyanate-induced cholestasis through activation of the Sirt1/FXR signaling pathway
期刊论文
Acta pharmacologica Sinica, 2018, 卷号: 39, 期号: 12, 页码: 1865-1873
作者:
Wu, Shou-Yan
;
Cui, Shi-Chao
;
Wang, Le
;
Zhang, Yi-Ting
;
Yan, Xiao-Xia
收藏
  |  
浏览/下载:96/0
  |  
提交时间:2019/01/08
Identification, structure modification, and characterization of potential small-molecule SGK3 inhibitors with novel scaffolds
期刊论文
Acta pharmacologica Sinica, 2018, 卷号: 39, 期号: 12, 页码: 1902-1912
作者:
Gong, Grace Qun
;
Wang, Ke
;
Dai, Xin-Chuan
;
Zhou, Yan
;
Basnet, Rajesh
收藏
  |  
浏览/下载:101/0
  |  
提交时间:2019/01/08
18 beta-Glycyrrhetinic acid protects against alpha-naphthylisothiocyanate-induced cholestasis through activation of the Sirt1/FXR signaling pathway
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 12, 页码: 1865-1873
作者:
Wu, Shou-yan
;
Cui, Shi-chao
;
Wang, Le
;
Zhang, Yi-ying
;
Yan, Xiao-xia
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2020/07/01
hepatoprotective effect
cholestatic liver injury
18 beta-glycyrrhetinic acid (18b-GA)
FXR
Sirt1
bile acid transporters
Different structures of berberine and five other protoberberine alkaloids that affect P-glycoprotein-mediated efflux capacity
期刊论文
Acta pharmacologica Sinica, 2018
作者:
Zhang, Yi-Ting
;
Yu, Yu-Qi
;
Yan, Xiao-Xia
;
Wang, Wen-Jie
;
Tian, Xiao-Ting
收藏
  |  
浏览/下载:70/0
  |  
提交时间:2019/01/08
Effect of Fluconazole on the Pharmacokinetic Properties of Imrecoxib, a Novel NSAID: A Single-center, Open-label, Self-controlled Study in Healthy Chinese Male Volunteers
期刊论文
CLINICAL THERAPEUTICS, 2018, 卷号: 40, 期号: 8, 页码: 1347-1356
作者:
Zuo, Cheng-zi
;
Gong, Yi
;
Hou, Xiang-yu
;
Zhang, Yi-fan
;
Peng, Wen-xing
收藏
  |  
浏览/下载:75/0
  |  
提交时间:2019/01/08
COX-2 inhibitor
drug interaction
fluconazole
imrecoxib
pharmacokinetics
NASID
Hydroxyl Group-Prompted and Iridium(III)-Catalyzed Regioselective C-H Annulation of N-phenoxyacetamides with Propargyl Alcohols
期刊论文
ADVANCED SYNTHESIS & CATALYSIS, 2018, 卷号: 360, 期号: 13, 页码: 2470-2475
作者:
Chen, Weijie
;
Liu, Fu-Xiaomin
;
Gong, Wanchun
;
Zhou, Zhi
;
Gao, Hui
收藏
  |  
浏览/下载:68/0
  |  
提交时间:2019/01/08
Iridium(III) catalysts
C-H annulation
N-phenoxyacetamides
tertiary propargyl alcohols
benzofurans
Catalyst-Controlled [3+2] and [4+2] Annulations of Oximes with Propargyl Alcohols: Divergent Access to Indenamines and Isoquinolines
期刊论文
ORGANIC LETTERS, 2018, 卷号: 20, 期号: 1, 页码: 182-185
作者:
Gong, Wanchun
;
Zhou, Zhi
;
Shi, Jingjing
;
Wu, Bo
;
Huang, Biyun
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 143, 页码: 33-47
作者:
Xu, Yi-xiang
;
Wang, Huan
;
Li, Xiao-kang
;
Dong, Sheng-nan
;
Liu, Wen-wen
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/01/08
Multifunctional agents
AChE inhibitors
MAO-B inhibitors
Metal chelating agents
Alzheimer's disease
identificationstructuremodificationandcharacterizationofpotentialsmallmoleculesgk3inhibitorswithnovelscaffolds
期刊论文
中国药理学报英文版, 2018, 卷号: 039, 期号: 012, 页码: 1902
作者:
Grace Qun Gong
;
Ke Wang
;
XinChuan Dai
;
Yan Zhou
;
Rajesh Basnet
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2020/07/01
serum
and
glucocorticoid-regulated
kinase
SGK3
high-throughput
screening
inhibitors
molecular
modeling
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