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浏览/检索结果: 共33条，第1-10条 帮助 限定条件 发表日期：2018    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Discovery of new potent protein arginine methyltransferase 5 (PRMT5) inhibitors by assembly of key pharmacophores from known inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 23-24, 页码: 3693-3699 作者:  Zhu, Kongkai;  Song, Jia-Li;  Tao, Hong-Rui;  Cheng, Zhi-Qiang;  Jiang, Cheng-Shi 收藏  |  浏览/下载：102/0  |  提交时间：2019/01/08 Pharmacophore combination  Isoquinoline  PRMT5 inhibitor  Molecular docking  Molecular dynamics simulation   C11, a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor, suppresses breast cancer metastasis and angiogenesis 期刊论文 Acta pharmacologica Sinica, 2018 作者:  Chen, Zhuo;  Tong, Lin-Jiang;  Tang, Bai-You;  Liu, Hong-Yan;  Wang, Xin 收藏  |  浏览/下载：105/0  |  提交时间：2019/01/08 Structure-Based Design of 1-Heteroary1-1,3-propanediamine Derivatives as a Novel Series of CC-Chemokine Receptor 5 Antagonists 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 21, 页码: 9621-9636 作者:  Peng, Panfeng;  Chen, Huan;  Zhu, Ya;  Wang, Zhilong;  Li, Jian 收藏  |  浏览/下载：57/0  |  提交时间：2019/01/08 Development and evaluation of a novel series of Nitroxoline-derived BET inhibitors with antitumor activity in renal cell carcinoma 期刊论文 ONCOGENESIS, 2018, 卷号: 7 作者:  Chen, Wei;  Zhang, Hao;  Chen, Zhifeng;  Jiang, Hao;  Liao, Liping 收藏  |  浏览/下载：109/0  |  提交时间：2019/01/08 Discovery and biological evaluation of thiobarbituric derivatives as potent p300/CBP inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 20, 页码: 5397-5407 作者:  Lu, Wenchao;  Xiong, Huan;  Chen, Yu;  Wang, Chen;  Zhang, Hao 收藏  |  浏览/下载：143/0  |  提交时间：2019/01/08 Drug discovery  Epigenetics  Histone acetyltransferase  P300/CBP   Coordinated biosynthesis of the purine nucleoside antibiotics aristeromycin and coformycin in actinomycetes 期刊论文 Applied and Environmental Microbiology, 2018, 卷号: 84, 期号: 22 作者:  Xu, Gudan;  Kong, Liyuan;  Gong, Rong;  Xu, Liudong;  Gao, Yaojie 收藏  |  浏览/下载：44/0  |  提交时间：2019/01/08 The role of formation of pyrrole-ATP synthase subunit beta adduct in pyrrolizidine alkaloid-induced hepatotoxicity 期刊论文 ARCHIVES OF TOXICOLOGY, 2018, 卷号: 92, 期号: 11, 页码: 3403-3414 作者:  Lu, Yao;  Ma, Jiang;  Song, Zijing;  Ye, Yang;  Fu, Peter P. 收藏  |  浏览/下载：39/0  |  提交时间：2019/01/08 Pyrrolizidine alkaloid  Retrorsine  ATP5B  Mitochondrial damage  Pyrrole-protein adduct   Design, synthesis, and biological evaluation of 2-(phenoxyaryl)-3-urea derivatives as novel P2Y(1) receptor antagonists 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 302-310 作者:  Peng, Jingjing;  Zhao, Lifen;  Wang, Lanlan;  Chen, Hui;  Qiu, Yunguang 收藏  |  浏览/下载：48/0  |  提交时间：2019/01/08 P2Y(1) receptor antagonist  2-(phenoxyaryl)-3-urea derivatives  Anti-Platelet   Chemical Resolution of C,N-Unprotected alpha-Substituted beta-Amino Acids Using Stable and Recyclable Proline-Derived Chiral Ligands 期刊论文 JOURNAL OF ORGANIC CHEMISTRY, 2018, 卷号: 83, 期号: 17, 页码: 9870-9878 作者:  Wang, Shuni;  Nian, Yong;  Zhou, Shengbin;  Wang, Jiang;  Liu, Hong 收藏  |  浏览/下载：29/0  |  提交时间：2019/01/08 Identification of novel inhibitors of histone acetyltransferase hMOF through high throughput screening 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 157, 页码: 867-876 作者:  Zhang, Rukang;  Wang, Jiang;  Zhao, Liang;  Liu, Shien;  Du, Daohai 收藏  |  浏览/下载：37/0  |  提交时间：2019/01/08 High throughput screening  Epigenetics  Histone acetyltransferase  MOF  Inhibitor