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浏览/检索结果: 共5条，第1-5条 帮助 限定条件 发表日期：2013    专题：中南大学    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Tyrosylprotein Sulfotransferase-1 and Tyrosine Sulfation of Chemokine Receptor 4 Are Induced by Epstein-Barr Virus Encoded Latent Membrane Protein 1 and Associated with the Metastatic Potential of Human Nasopharyngeal Carcinoma 期刊论文 PLOS ONE, 2013, 卷号: 8, 期号: 3, 页码: e56114 作者:  Xu, Juan;  Deng, Xiyun;  Tang, Min;  Li, Lili;  Xiao, Lanbo 收藏  |  浏览/下载：3/0  |  提交时间：2019/12/03 Nasopharyngeal carcinoma,Sulfation,Tyrosine,Metastasis,Cell migration,Small interfering RNAs,Immunoprecipitation,Chemokines   The A/G allele of eIF3a rs3740556 predicts platinum-based chemotherapy resistance in lung cancer patients 期刊论文 Lung Cancer, 2013, 卷号: 79, 期号: 1, 页码: 65-72 作者:  Xu, Xiaojing;  Han, Lifang;  Yang, Huaping;  Duan, Li;  Zhou, Boting 收藏  |  浏览/下载：2/0  |  提交时间：2019/12/03 eIF3a  Lung cancer  Platinum chemotherapy  Resistance  Survival analysis   Antiangiogenic and Antitumoral Effects Mediated by a Vascular Endothelial Growth Factor Receptor 1 (VEGFR-1)-Targeted DNAzyme 期刊论文 Molecular Medicine, 2013, 卷号: 19, 期号: 1, 页码: 377-386 作者:  Shen, Liangfang;  Zhou, Qin;  Wang, Ying;  Liao, Weihua;  Chen, Yan 收藏  |  浏览/下载：3/0  |  提交时间：2019/12/03 Association between eIF3α polymorphism and severe toxicity caused by platinum‐based chemotherapy in non‐small cell lung cancer patients 期刊论文 British Journal of Clinical Pharmacology, 2013, 卷号: 75, 期号: 2, 页码: 522-534 作者:  Xu, Xiaojing;  Han, Lifang;  Duan, Li;  Zhao, Yingchun;  Yang, Huaping 收藏  |  浏览/下载：8/0  |  提交时间：2019/12/03 eIF3α  nephrotoxicity  non‐small cell lung cancer (NSCLC)  ototoxicity  platinum toxicity   Delivery system for DNAzymes using arginine-modified hydroxyapatite nanoparticles for therapeutic application in a nasopharyngeal carcinoma model 期刊论文 International Journal of Nanomedicine, 2013, 卷号: 8, 期号: 1, 页码: 3107-3118 作者:  Chen, Yan;  Yang, Lifang*;  Huang, Suping;  Li, Zhi;  Zhang, Lu 收藏  |  浏览/下载：8/0  |  提交时间：2019/12/03 DNAzymes are synthetic  single-stranded  catalytic nucleic acids that bind and cleave target mRNA in a sequence-specific manner  and have been explored for genotherapeutics. One bottleneck restricting their application is the lack of an efficient delivery system. As an inorganic nanomaterial with potentially wide application  nanohydroxyapatite particles (nHAP) have attracted increasing attention as new candidates for nonviral vectors. In this study  we developed an nHAP-based delivery system and explored its cellular uptake mechanisms  intracellular localization  and biological effects. Absorption of arginine-modified nanohydroxyapatite particles (Arg-nHAP) and DZ1 (latent membrane protein 1 [LMP1]-targeted) reached nearly 100% efficiency under in vitro conditions. Using specific inhibitors  cellular uptake of the Arg-nHAP/DZ1 complex was shown to be mediated by the energy-dependent endocytosis pathway. Further  effective intracellular delivery and nuclear localization of the complex was confirmed by confocal microscopy. Biologically  the complex successfully downregulated the expression of LMP1 in nasopharyngeal carcinoma cells. In a mouse tumor xenograft model  the complex was shown to be delivered efficiently to tumor tissue  downregulating expression of LMP1 and suppressing tumor growth. These results suggest that Arg-nHAP may be an efficient vector for nucleic acid-based drugs with potential clinical application.