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浏览/检索结果: 共9条，第1-9条 帮助 限定条件 专题：中南大学    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Aucubin and its hydrolytic derivative attenuate activation of hepatic stellate cells via modulation of TGF-β stimulation 期刊论文 Environmental Toxicology and Pharmacology, 2017, 卷号: 50, 页码: 234-239 作者:  Lv, Pei-Yu;  Feng, Han;  Huang, Wei-Hua;  Tian, Ying-Ying;  Wang, Ya-Qin 收藏  |  浏览/下载：2/0  |  提交时间：2019/12/03 AU  aucubin  AUG  aucubigenin  Col I  collagen I  Col III  collagen III  ECM  extracellular matrix  α-SMA  alpha smooth muscle actin  LX-2  human hepatic stellate cell  TGF-β1  transforming growth factor-β1  CTGF  connective tissue growth factor  MDA  malondialdehyde  CAT  catalase  GSH-Px  glutathione peroxidase  SOD  superoxide dismutase  DPPH  1,1-diphenyl-2-picrylhydrazyl radical 2,2-diphenyl-1-(2,4,6-trinitrophenyl) hydrazyl  p38 MAPK  P38 mitogen activated protein kinase  Human hepatic stellate cells  Aucubin  Aucubigenin  Extracellular matrix  TGF-β1   Effects of A2BR on the biological behavior of mouse renal fibroblasts during hypoxia 期刊论文 Molecular Medicine Reports, 2015, 卷号: 11, 期号: 6, 页码: 4397-4402 作者:  Tang, Jin;  Jiang, Xianzhen;  Zhou, Yihong;  Dai, Yingbo* 收藏  |  浏览/下载：4/0  |  提交时间：2019/12/03 hypoxia  fibroblast  adenosine receptor  cytokine  alpha-smooth muscle actin   Increased adenosine levels contribute to ischemic kidney fibrosis in the unilateral ureteral obstruction model 期刊论文 Experimental and Therapeutic Medicine, 2015, 卷号: 9, 期号: 3, 页码: 737-743 作者:  Tang, Jin;  Jiang, Xianzhen;  Zhou, Yihong;  Xia, Bing;  Dai, Yingbo* 收藏  |  浏览/下载：3/0  |  提交时间：2019/12/03 adenosine  cytokines  renal interstitial fibrosis  unilateral ureteral obstruction model  alpha-smooth muscle actin   The role of vascular peroxidase 1 in ox-LDL-induced vascular smooth muscle cell calcification. 期刊论文 Atherosclerosis, 2015, 卷号: 243, 期号: 2, 页码: 357-363 作者:  Tang, Yixin;  Xu, Qian;  Peng, Haiyang;  Liu, Zhaoya;  Yang, Tianlun 收藏  |  浏览/下载：12/0  |  提交时间：2019/12/03 Vascular peroxidase 1  Osteogenic differentiation  Vascular calcification  Oxidized low-density lipoprotein  Vascular smooth muscle cells  ROS  reactive oxygen species  VSMCs  vascular smooth muscle cells  HOCl  hypochlorous acid  H2O2  hydrogen peroxide  ox-LDL  oxidized low-density lipoprotein  ALP  alkaline phosphatase  Runx2  runt-related transcription factor 2  VPO1  vascular peroxidase 1  MPO  myeloperoxidase  Nox  nicotinamide adenine dinucleotide phosphate oxidases  DPI  diphenyliodonium  SMA  smooth muscle α-actin  3-Cl-Tyr  3-chlorotyrosine   Potential biomarkers for early diagnosis of acute aortic dissection 期刊论文 Heart and Lung: Journal of Acute and Critical Care, 2015, 卷号: 44, 期号: 3, 页码: 205-208 作者:  Peng, Wen;  Peng, Zhenyu;  Chai, Xiangping*;  Zhu, Qingyi;  Yang, Guifang 收藏  |  浏览/下载：6/0  |  提交时间：2019/12/03 Acute aortic dissection  Biomarkers  D-dimer  Polycystin 1  Smooth muscle myosin heavy chain  Soluble elastin fragments  alpha-Smooth muscle actin   FLUOROFENIDONE ATTENUATES TGF-beta(1)-INDUCED LUNG FIBROBLAST ACTIVATION VIA RESTORING THE EXPRESSION OF CAVEOLIN-1 期刊论文 Shock (Augusta, Ga.), 2015, 卷号: 43, 期号: 2, 页码: 201-207 作者:  Liu, Jingjing;  Song, Cheng;  Xiao, Qiming;  Hu, Gaoyun;  Tao, Lijian 收藏  |  浏览/下载：4/0  |  提交时间：2019/12/03 Idiopathic pulmonary fibrosis  extracellular matrix  transforming growth factor-beta  alpha-smooth muscle actin  fibronectin  pyridine agent   Paclitaxel attenuates renal interstitial fibroblast activation and interstitial fibrosis by inhibiting STAT3 signaling 期刊论文 Drug Design, Development and Therapy, 2015, 卷号: 9, 页码: 2139-2148 作者:  Zhang, Lei;  Xu, Xuan;  Yang, Ruhao;  Chen, Jingwen;  Wang, Shixuan 收藏  |  浏览/下载：4/0  |  提交时间：2019/12/03 Recent studies have demonstrated that paclitaxel might inhibit renal fibrosis. However  the underlying molecular mechanism remains unclear. In this study  we hypothesized that low-dose paclitaxel may block the STAT3 (signal transducer and activator of transcription 3) signaling to attenuate fibrosis in a mouse model with unilateral ureteral obstruction. Both NRK-49F cells and mice with unilateral ureteral obstruction were treated with paclitaxel. The results showed that paclitaxel treatment resulted in a dose- and time-dependent decrease in tyrosine-phosphorylated STAT3  and inhibited the expression of fibronectin  alpha-smooth muscle actin (α-SMA)  and collagen I in cultured NRK-49F cells. S3I-201  an STAT3 inhibitor  also suppressed the expression of fibronectin  α-SMA  and collagen I in cultured NRK-49F cells. Mechanistically  paclitaxel treatment blocked the STAT3 activity by disrupting the association of STAT3 with tubulin and inhibiting STAT3 nucleus translocation. Furthermore  paclitaxel also ameliorated renal fibrosis by down-regulating the expression of fibronectin  α-SMA  and collagen I  and suppressed the infiltration of macrophages and production of TNF-α  IL-1β  TGF-β  and ICAM-1 (intercellular adhesion molecule 1) by inhibition of STAT3 activity in obstructive nephropathy. These results suggest that paclitaxel may block the STAT3 activity by disrupting the association of STAT3 with tubulin and inhibiting STAT3 nucleus translocation  consequently leading to the suppression of renal interstitial fibroblast activation and the development of renal fibrosis  and inhibition of proinflammatory cytokine production.   Rosiglitazone attenuates activation of human Tenon's fibroblasts induced by transforming growth factor -beta 1 期刊论文 Graefe's Archive for Clinical and Experimental Ophthalmology, 2012, 卷号: 250, 期号: 8, 页码: 1213-1220 作者:  Fan, Fang;  Li, Yuehua;  Duan, Xuanchu*;  Zhao, Tantai;  Pan, Dongning 收藏  |  浏览/下载：7/0  |  提交时间：2019/12/03 Rosiglitazone  Transforming growth factor beta  Human Tenon’s fibroblasts  Alpha smooth muscle actin   Actin-binding rho activating protein (Abra) is essential for fluid shear stress-induced arteriogenesis. 期刊论文 Arteriosclerosis, Thrombosis, and Vascular Biology, 2009, 卷号: 29, 期号: 12, 页码: 2093-U249 作者:  Troidl, Kerstin*;  Rueding, Inka;  Cai, Wei-Jun;  Muecke, Yvonne;  Grossekettler, Leonie 收藏  |  浏览/下载：5/0  |  提交时间：2019/12/03 arteriogenesis  Abra  fluid shear stress  smooth muscle cells  proliferation