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科研机构
上海药物研究所 [74]
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期刊论文 [74]
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2021 [4]
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Histone deacetylase inhibitor givinostat attenuates nonalcoholic steatohepatitis and liver fibrosis
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 13
作者:
Huang, He-ming
;
Fan, Shi-jie
;
Zhou, Xiao-ru
;
Liu, Yan-jun
;
Li, Xiao
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2021/11/04
nonalcoholic steatohepatitis
inflammation
histone deacetylase inhibitor
givinostat
epigenetics
Identification of novel anti-inflammatory Nur77 modulators by virtual screening
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 112, 页码: 7
作者:
Ding, Xiaoyu
;
Zhao, Zijie
;
Wu, Yue
;
Zhang, Hao
;
Chen, Kaixian
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2021/08/17
Nur77
Binding site evaluation
Virtual Screening
Inflammation
A novel low systemic diacylglycerol acyltransferase 1 inhibitor, Yhhu2407, improves lipid metabolism
期刊论文
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2021, 卷号: 158, 页码: 9
作者:
Huang, Jun-Shang
;
Guo, Bin-Bin
;
Lin, Fei-Fei
;
Zeng, Li-Min
;
Wang, Ting
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2021/05/24
DGAT1
Inhibitor
Pharmacokinetics
Dyslipidemia
Lipid metabolism
Three new sesquineolignans from the seeds of Ziziphus jujuba
期刊论文
NATURAL PRODUCT RESEARCH, 2021, 页码: 6
作者:
Mi, Wen
;
Guo, Yue-jiao
;
Hu, Pei
;
Di, Xin
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2021/05/24
Ziziphus jujuba
sesquineolignan
structure elucidation
cytotoxicity
Synthesis and Cytotoxic Activity of Novel C-23-Modified Asiatic Acid Derivatives
期刊论文
MOLECULES, 2020, 卷号: 25, 期号: 16, 页码: 20
作者:
Lu, Yi-hong
;
Chen, Ming-cang
;
Liu, Fang
;
Xu, Zhou
;
Tian, Xiao-ting
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2020/12/24
asiatic acid
modification at C-23
intramolecular hydrogen bonding
cytotoxic activity
Discovery of a 2-pyridinyl urea-containing compound YD57 as a potent inhibitor of apoptosis signal-regulating kinase 1 (ASK1)
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 195, 页码: 13
作者:
Zhang, Shiyan
;
Huang, Chaoying
;
Lyu, Xilin
;
Wang, Peipei
;
Zang, Yi
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2020/07/01
ASK1
ASK2
Selectivity
Apoptosis
Cell cycle arrest
Discovery of dihydrooxazolo[2,3-a]isoquinoliniums as highly specific inhibitors of hCE2
期刊论文
RSC ADVANCES, 2019, 卷号: 9, 期号: 61, 页码: 35904-35912
作者:
Ding, Lixia
;
Wang, Lu
;
Zou, Kun
;
Li, Bo
;
Song, Yunqing
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2020/07/01
PD-L1 expression levels on tumor cells affect their immunosuppressive activity
期刊论文
ONCOLOGY LETTERS, 2019, 卷号: 18, 期号: 5, 页码: 5399-5407
作者:
Zheng, Yang
;
Fang, You-Chen
;
Li, Jing
收藏
  |  
浏览/下载:54/0
  |  
提交时间:2020/07/01
programmed cell death 1
programmed death-ligand 1
co-culture
immunosuppression
signaling pathway
Targeted photoswitchable imaging of intracellular glutathione by a photochromic glycosheet sensor
期刊论文
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 2019, 卷号: 15, 页码: 2380-2389
作者:
Chai, Xianzhi
;
Han, Hai-Hao
;
Zang, Yi
;
Li, Jia
;
He, Xiao-Peng
收藏
  |  
浏览/下载:69/0
  |  
提交时间:2020/07/01
intracellular GSH
molecular switches
photochromic glycosheet
photoswitchable imaging
2D MnO2 nanosheets
Exploration of the hepatoprotective chemical base of an orally administered herbal formulation (YCHT) in normal and CCl4-intoxicated liver injury rats. Part 2: Hepatic disposition in vivo and hepatoprotective activity in vitro
期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2019, 卷号: 236, 页码: 161-172
作者:
Tian, Xiaoting
;
Liu, Huan
;
Qiao, Shida
;
Yin, Hao
;
Chen, Mingcang
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2020/07/01
Yin-Chen-Hao Tang
Hepatic disposition
Pharmacokinetics
Hepatoprotection
HepG2
Carbon tetrachloride
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