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科研机构
上海药物研究所 [20]
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期刊论文 [20]
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2020 [3]
2019 [2]
2018 [5]
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Discovery of novel USP8 inhibitors via Ubiquitin-Rho-110 fluorometric assay based high throughput screening
期刊论文
BIOORGANIC CHEMISTRY, 2020, 卷号: 101, 页码: 9
作者:
Han, Jie
;
Tian, Yucheng
;
Yu, Liang
;
Zhang, Qilin
;
Xu, Xi
收藏
  |  
浏览/下载:64/0
  |  
提交时间:2020/12/24
Ubiquitination
High throughput screening
Drug discovery
USP8
Structure of M-pro from SARS-CoV-2 and discovery of its inhibitors
期刊论文
NATURE, 2020, 页码: 24
作者:
Jin, Zhenming
;
Du, Xiaoyu
;
Xu, Yechun
;
Deng, Yongqiang
;
Liu, Meiqin
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  |  
浏览/下载:41/0
  |  
提交时间:2020/07/01
Discovery of Highly Potent, Selective, and Orally Efficacious p300/CBP Histone Acetyltransferases Inhibitors
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 3, 页码: 1337-1360
作者:
Yang, Yaxi
;
Zhang, Rukang
;
Li, Zhaojun
;
Mei, Lianghe
;
Wan, Shili
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  |  
浏览/下载:41/0
  |  
提交时间:2020/07/01
Novel dihydroartemisinin dimer containing nitrogen atoms inhibits growth of endometrial cancer cells and may correlate with increasing intracellular peroxynitrite
期刊论文
SCIENTIFIC REPORTS, 2019, 卷号: 9, 页码: 14
作者:
Zhu, Yan
;
Klausen, Christian
;
Zhou, Jieyun
;
Guo, Xiangjie
;
Zhang, Yu
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  |  
浏览/下载:81/0
  |  
提交时间:2020/07/01
Discovery of Novel Janus Kinase (JAK) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Hematological Malignancies
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 8, 页码: 3898-3923
作者:
Liang, Xuewu
;
Zang, Jie
;
Li, Xiaoyang
;
Tang, Shuai
;
Huang, Min
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  |  
浏览/下载:21/0
  |  
提交时间:2020/07/01
Disulfiram Copper Nanoparticles Prepared with a Stabilized Metal Ion Ligand Complex Method for Treating Drug-Resistant Prostate Cancers
期刊论文
ACS APPLIED MATERIALS & INTERFACES, 2018, 卷号: 10, 期号: 48, 页码: 41118-41128
作者:
Chen, Wu
;
Yang, Wen
;
Chen, Pengyu
;
Huang, Yongzhuo
;
Li, Feng
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  |  
浏览/下载:98/0
  |  
提交时间:2019/01/08
disulfiram
copper diethyldithiocarbamate
drug resistance
prostate cancer
nanoparticle
drug delivery
paraptosis
Discovery of 1,8-acridinedione derivatives as novel GCN5 inhibitors via high throughput screening
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 151, 页码: 740-751
作者:
Xiong, Huan
;
Han, Jie
;
Wang, Jun
;
Lu, Wenchao
;
Wang, Chen
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/01/08
Epigenetics
Histone acetyltransferase
GCN5
High throughput screening
1,8-Acridinedione derivative
Enhancing inactivation rather than reducing activation of Nav1.7 channels by a clinically effective analgesic CNV1014802
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 4, 页码: 587-596
作者:
Zheng, Yue-ming
;
Wang, Wan-fu
;
Li, Yan-fen
;
Yu, Yong
;
Gao, Zhao-bing
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  |  
浏览/下载:50/0
  |  
提交时间:2019/01/08
Nav1.7 channels
analgesics
CNV1014802
inactivated state
paroxysmal extreme pain disorder
Discovery of Potent Benzocycloalkane Derived Diapophytoene Desaturase Inhibitors with an Enhanced Safety Profile for the Treatment of MRSA, VISA, and LRSA Infections
期刊论文
ACS INFECTIOUS DISEASES, 2018, 卷号: 4, 期号: 3, 页码: 208-217
作者:
Li, Baoli
;
Ni, Shuaishuai
;
Chen, Feifei
;
Mao, Fei
;
Wei, Hanwen
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2019/01/08
Staphylococcus aureus
diapophytoene desaturase
methicillin-resistant Staphylococcus aureus
hERG safety
Interaction assessments of the first S-adenosylmethionine competitive inhibitor and the essential interacting partner methylosome protein 50 with protein arginine methyltransferase 5 by combined computational methods
期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 卷号: 495, 期号: 1, 页码: 721-727
作者:
Zhu, Kongkai
;
Jiang, Cheng-Shi
;
Hu, Junchi
;
Liu, Xigong
;
Yan, Xue
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2019/01/08
PRMT5 SAM competitive inhibitor
Molecular docking
Molecular dynamics simulation
Molecular mechanics/Poisson-Boltzmann surface area
PRMT5:MEP50 interaction
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