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科研机构
上海药物研究所 [16]
内容类型
期刊论文 [16]
发表日期
2021 [1]
2018 [5]
2017 [1]
2015 [1]
2014 [1]
2013 [1]
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Identification of phosphodiesterase-4 as the therapeutic target of arctigenin in alleviating psoriatic skin inflammation
期刊论文
JOURNAL OF ADVANCED RESEARCH, 2021, 卷号: 33, 页码: 241-251
作者:
Li, Heng
;
Zhang, Xianglei
;
Xiang, Caigui
;
Feng, Chunlan
;
Fan, Chen
收藏
  |  
浏览/下载:89/0
  |  
提交时间:2021/11/04
PDE4
Arctigenin
Psoriasis
Inflammation
Novel Tadalafil Derivatives Ameliorates Scopolamine-Induced Cognitive Impairment in Mice via Inhibition of Acetyicholinesterase (AChE) and Phosphodiesterase 5 (PDE5)
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2018, 卷号: 9, 期号: 7, 页码: 1625-1636
作者:
Ni, Wei
;
Wang, Huan
;
Li, Xiaokang
;
Zheng, Xinyu
;
Wang, Manjiong
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2019/01/08
Multifunctional agents
AChE inhibitors
PDE5 inhibitors
Alzheimer's disease
Cananga odorata essential oil reverses the anxiety induced by 1-(3-chlorophenyl) piperazine through regulating the MAPK pathway and serotonin system in mice
期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2018, 卷号: 219, 页码: 23-30
作者:
Zhang, Nan
;
Zhang, Lei
;
Feng, Linyin
;
Yao, Lei
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2019/01/08
Cananga odorata
1-(3-Chlorophenyl) piperazine
Anxiolytic effect
MAPK
5-HT
Linderane Suppresses Hepatic Gluconeogenesis by Inhibiting the cAMP/PKA/CREB Pathway Through Indirect Activation of PDE 3 via ERK/STAT3
期刊论文
FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9
作者:
Xie, Wei
;
Ye, Yangliang
;
Feng, Ying
;
Xu, Tifei
;
Huang, Suling
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2019/01/08
cAMP
gluconeogenesis
linderane
phosphodiesterase
type 2 diabetes
Metabolic benefits of inhibition of p38 alpha in white adipose tissue in obesity
期刊论文
PLOS BIOLOGY, 2018, 卷号: 16, 期号: 5
作者:
Zhang, Shengjie
;
Cao, Hongchao
;
Li, Yan
;
Jing, Yanyan
;
Liu, Shengnan
收藏
  |  
浏览/下载:97/0
  |  
提交时间:2019/01/08
Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer's Disease
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2018, 卷号: 9, 期号: 2, 页码: 328-345
作者:
Mao, Fei
;
Wang, Huan
;
Ni, Wei
;
Zheng, Xinyu
;
Wang, Manjiong
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2019/01/08
Alzheimer's disease
drug repositioning
dual-target inhibitor
AChE inhibition
PDE5 inhibition
Nuclear Accumulation of Histone Deacetylase 4 (HDAC4) Exerts Neurotoxicity in Models of Parkinson's Disease
期刊论文
MOLECULAR NEUROBIOLOGY, 2017, 卷号: 54, 期号: 9, 页码: 6970-6983
作者:
Wu, Qimei
;
Yang, Xiaoyu
;
Zhang, Lei
;
Zhang, Yu
;
Feng, Linyin
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2019/01/08
HDAC4
alpha-Synuclein
Neuroprotection
Parkinson's disease
PKC
Dorsal hippocampal NMDA receptor blockade impairs extinction of naloxone-precipitated conditioned place aversion in acute morphine-treated rats by suppressing ERK and CREB phosphorylation in the basolateral amygdala
期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2015, 卷号: 172, 期号: 2, 页码: 482-491
作者:
Wang, Wei-Sheng
;
Chen, Zhong-Guo
;
Liu, Wen-Tao
;
Chi, Zhi-Qiang
;
He, Ling
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
drug withdrawal
extinction
amygdala
hippocampal
A stress response pathway in mice upregulates somatostatin level and transcription in pancreatic delta cells through Gs and beta-arrestin 1
期刊论文
DIABETOLOGIA, 2014, 卷号: 57, 期号: 9, 页码: 1899-1910
作者:
Wang, Hong-Mei
;
Dong, Jun-Hong
;
Li, Qing
;
Hu, Qiaoxia
;
Ning, Shang-Lei
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/01/08
Adrenergic receptors
beta-Arrestin 1
CREB
Pancreatic delta cell
PAX6
PDX1
Somatostatin
Stress
Dodoviscin A Inhibits Melanogenesis in Mouse B16-F10 Melanoma Cells
期刊论文
PLANTA MEDICA, 2013, 卷号: 79, 期号: 11, 页码: 933-938
作者:
Yan, Guirui
;
Zhu, Jingjie
;
Zhang, Laibin
;
Xu, Zhijian
;
Wang, Gaihong
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
dodoviscin A
Dodonaea viscosa
Sapindaceae
melanogenesis
tyrosinase
CREB
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