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科研机构
上海药物研究所 [23]
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期刊论文 [22]
会议论文 [1]
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2021 [1]
2020 [1]
2019 [1]
2018 [3]
2017 [3]
2016 [4]
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Desorption electrospray ionization (DESI) source coupling ion mobility mass spectrometry for imaging fluoropezil (DC20) distribution in rat brain
期刊论文
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2021, 页码: 13
作者:
Guo, Runcong
;
Zhou, Lei
;
Chen, Xiaoyan
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2021/11/04
DESI
Mass spectrometry imaging
Fluoropezil (DC20)
Brain distribution
Optimization strategy
Enhanced oral bioavailability and bioefficacy of phloretin using mixed polymeric modified self-nanoemulsions
期刊论文
FOOD SCIENCE & NUTRITION, 2020, 页码: 14
作者:
Wang, Yiling
;
Li, Dongli
;
Lin, Huiqiong
;
Jiang, Sen
;
Han, Lei
收藏
  |  
浏览/下载:142/0
  |  
提交时间:2020/07/01
anti-inflammatory
bioavailability
pharmacokinetics
phloretin
self-nanoemulsions
solubility
NEK2 promotes proliferation, migration and tumor growth of gastric cancer cells via regulating KDM5B/H3K4me3
期刊论文
AMERICAN JOURNAL OF CANCER RESEARCH, 2019, 卷号: 9, 期号: 11, 页码: 2364-2378
作者:
Li, Yiwei
;
Chen, Lijuan
;
Feng, Lixing
;
Zhu, Mengli
;
Shen, Qiang
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2020/07/01
Gastric cancer
NEK2
KDM5B
beta-catenin
c-Myc
Identification of 5-benzylidene-2-phenylthiazolones as potent PRMT5 inhibitors by virtual screening, structural optimization and biological evaluations
期刊论文
BIOORGANIC CHEMISTRY, 2018, 卷号: 81, 页码: 289-298
作者:
Zhu, Kongkai
;
Tao, Hongrui
;
Song, Jia-Li
;
Jin, Lu
;
Zhang, Yuanyuan
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  |  
浏览/下载:130/0
  |  
提交时间:2019/01/08
PRMT5 inhibitor
Arginine methylation
Virtual screening
Molecular docking
Molecular dynamics simulation
Synthesis, biological evaluation and structure-activity relationship of a novel class of PI3K alpha H1047R mutant inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 707-719
作者:
Zhang, Ning
;
Yu, Zhimei
;
Yang, Xiaohong
;
Zhou, Yan
;
Wang, Jia
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  |  
浏览/下载:90/0
  |  
提交时间:2019/01/08
Anticancer drug
Phosphatidylinositol 3-kinase
Structure-activity relationship
Simultaneous determination of eight bioactive compounds by LC-MS/MS and its application to the pharmacokinetics, liver first-pass effect, liver and brain distribution of orally administrated Gouteng-Baitouweng (GB) in rats
期刊论文
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2018, 卷号: 1084, 页码: 122-131
作者:
Tian, Xiaoting
;
Xu, Zhou
;
Chen, Mingcang
;
Hu, Pei
;
Liu, Fang
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  |  
浏览/下载:33/0
  |  
提交时间:2019/01/08
Gouteng-Baitouweng
LC-MS/MS
Pharmacokinetics
Liver
Brain
liver first-pass effect
A novel glucagon-like peptide-1/glucagon receptor dual agonist exhibits weight-lowering and diabetes-protective effects
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 138, 页码: 1158-1169
作者:
Zhou, Jie
;
Cai, Xingguang
;
Huang, Xun
;
Dai, Yuxuan
;
Sun, Lidan
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  |  
浏览/下载:32/0
  |  
提交时间:2019/01/08
Glucagon
GLP-1/GCGR agonist
Weight-lowering
Diabetes-protective
MiR-1254 suppresses HO-1 expression through seed region-dependent silencing and non-seed interaction with TFAP2A transcript to attenuate NSCLC growth
期刊论文
PLOS GENETICS, 2017, 卷号: 13, 期号: 7
作者:
Pu, Mengfan
;
Li, Chenggang
;
Qi, Xinming
;
Chen, Jing
;
Wang, Yizheng
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2019/01/08
Matrix Effects and Countermeasure of Liquid Chromatography-Tandem Mass Spectrometry in Bioanalysis
期刊论文
Journal of Chinese Mass Spectrometry Society, 2017, 卷号: 38, 期号: 4, 页码: 388-399
作者:
Liu, Xiao-Yun
;
Chen, Xiao-Yan
;
Zhong, Da-Fang
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
Waltonitone inhibits proliferation of hepatoma cells and tumorigenesis via FXR-miR-22-CCNA2 signaling pathway
期刊论文
Oncotarget, 2016, 卷号: 7, 期号: 46, 页码: 75165-75175
作者:
Yang, Fan
;
Gong, Junting
;
Wang, Guangyun
;
Chen, Peng
;
Yang, Li
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/01/08
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