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上海药物研究所 [242]
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期刊论文 [240]
会议论文 [1]
学位论文 [1]
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2021 [16]
2020 [23]
2019 [18]
2018 [25]
2017 [23]
2016 [27]
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Chemistry [2]
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Potent and Selective RIPK1 Inhibitors Targeting Dual-Pockets for the Treatment of Systemic Inflammatory Response Syndrome and Sepsis
期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 6
作者:
Yang, Xiangbo
;
Lu, Huimin
;
Xie, Hang
;
Zhang, Binbin
;
Nie, Tianqing
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2022/01/18
Binding studies
Drug discovery
Necroptosis
RIPK1 inhibitors
Sepsis
Conformational polymorphs of isotretinoin and their impact on physicochemical and biological properties
期刊论文
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2021, 卷号: 610, 页码: 10
作者:
Cheng, Yinxiang
;
Rong, Xiaoyi
;
Xia, Mengyuan
;
Zhang, Zaiyong
;
Wang, Jian-Rong
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  |  
浏览/下载:73/0
  |  
提交时间:2022/01/04
Polymorph
Isotretinoin
Stability
Solubility
Bioavailability
Theoretical study and application of 2-phenyl-1,3,4-thiadiazole derivatives with optical and inhibitory activity against SHP1
期刊论文
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2021, 页码: 14
作者:
Zhang, Chun
;
Sun, Yi-Tao
;
Gao, Li-Xin
;
Feng, Bo
;
Yan, Xue
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2022/01/18
Quantitative proteomic analysis uncovers inhibition of melanin synthesis by silk fibroin via MITF/tyrosinase axis in B16 melanoma cells
期刊论文
LIFE SCIENCES, 2021, 卷号: 284, 页码: 7
作者:
Wang, Yuqiu
;
Duan, Tianbi
;
Hong, Minhua
;
Zhou, Yanting
;
Huang, Hui
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2021/11/04
Silk fibroin
Quantitative proteomics
Melanin
Microphthalmia-associated transcription factor
Tyrosinase
5-Aminonaphthalene derivatives as selective nonnucleoside nuclear receptor binding SET domain-protein 2 (NSD2) inhibitors for the treatment of multiple myeloma
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 222, 页码: 19
作者:
Wang, Shuni
;
Yang, Hong
;
Su, Mingbo
;
Lian, Fulin
;
Cong, Zhanqing
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  |  
浏览/下载:83/0
  |  
提交时间:2021/11/04
NSD2
Methyltransferase
HTS
Multiple myeloma
5-Aminonaphthalene derivatives
Inhibitor
A proteomic and phosphoproteomic landscape of KRAS mutant cancers identifies combination therapies
期刊论文
MOLECULAR CELL, 2021, 卷号: 81, 期号: 19, 页码: 4076-+
作者:
Liu, Zhiwei
;
Liu, Yingluo
;
Qian, Lili
;
Jiang, Shangwen
;
Gai, Xiameng
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2021/12/01
Synthesis of 5-Phenyl-1,3,4-thiadiazole Derivatives and Their Biochemical Evaluation against Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 1 (SHP1)
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 41, 期号: 8, 页码: 3097-3105
作者:
Yu Lijie
;
Feng Bo
;
Wang Zhijia
;
Gao Lixin
;
Zhang Chun
收藏
  |  
浏览/下载:243/0
  |  
提交时间:2021/11/04
5-phenyl-1,3,4-thiadiazole derivatives
Src homology 2 domain-containing protein tyrosine phosphatase 1 (SHP1)
inhibitors
structure-activity relationships
Desorption electrospray ionization (DESI) source coupling ion mobility mass spectrometry for imaging fluoropezil (DC20) distribution in rat brain
期刊论文
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2021, 页码: 13
作者:
Guo, Runcong
;
Zhou, Lei
;
Chen, Xiaoyan
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  |  
浏览/下载:23/0
  |  
提交时间:2021/11/04
DESI
Mass spectrometry imaging
Fluoropezil (DC20)
Brain distribution
Optimization strategy
Biomimetic camouflage delivery strategies for cancer therapy
期刊论文
NANOSCALE, 2021, 页码: 14
作者:
Asrorov, Akmal M.
;
Gu, Zeyun
;
Li, Feng
;
Liu, Lingyun
;
Huang, Yongzhuo
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2021/06/11
Cyclin-dependent kinase inhibitor roscovitine attenuates liver inflammation and fibrosis by influencing initiating steps of liver injury
期刊论文
CLINICAL SCIENCE, 2021, 卷号: 135, 期号: 7, 页码: 925-941
作者:
Liu, Yanjun
;
Li, Jiacheng
;
Liao, Liping
;
Huang, Heming
;
Fan, Shijie
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2021/08/17
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