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科研机构
上海药物研究所 [14]
内容类型
期刊论文 [14]
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2021 [2]
2019 [1]
2017 [2]
2010 [1]
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2005 [2]
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Discovery of a novel, potent and selective small-molecule inhibitor of PD-1/PD-L1 interaction with robust in vivo anti-tumour efficacy
期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2021, 页码: 20
作者:
Liu, Chenglong
;
Zhou, Feilong
;
Yan, Ziqin
;
Shen, Lian
;
Zhang, Xichen
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2021/06/11
immunotherapy
PD-1/PD-L1
TGF-beta
tumour immune microenvironment
Histone deacetylase inhibitor givinostat alleviates liver fibrosis by regulating hepatic stellate cell activation
期刊论文
MOLECULAR MEDICINE REPORTS, 2021, 卷号: 23, 期号: 5, 页码: 12
作者:
Huang, He-Ming
;
Zhou, Xiao-Ru
;
Liu, Yan-Jun
;
Fan, Shi-Jie
;
Liao, Li-Ping
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2021/05/24
liver fibrosis
hepatic stellate cell
histone deacetylase inhibitor
epigenetics
givinostat
TGF-beta 1/p65/MAT2A pathway regulates liver fibrogenesis via intracellular SAM
期刊论文
EBIOMEDICINE, 2019, 卷号: 42, 页码: 458-469
作者:
Wang, Kuifeng
;
Fang, Shanhua
;
Liu, Qian
;
Gao, Jing
;
Wang, Xiaoning
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2020/07/01
Liver fibrosis
TGF-beta 1
MAT2A
p65
SAM
The Spatio-Temporal Expression Profiles of CD4+T Cell Differentiation and Function-Related Genes During EAE Pathogenesis
期刊论文
INFLAMMATION, 2017, 卷号: 40, 期号: 1, 页码: 195-204
作者:
Cai, Yingying
;
Shen, Hu
;
Qin, Chaoyan
;
Zhou, Jinfeng
;
Lai, Weiming
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2019/01/08
cytokine
experimental autoimmune encephalomyelitis
multiple sclerosis
transcription factor
Identification of Two Additional Susceptibility Loci for Inflammatory Bowel Disease in a Chinese Population
期刊论文
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2017, 卷号: 41, 期号: 5, 页码: 2077-2090
作者:
Lan, Xiucai
;
Lan, Xiuhua
;
Chang, Ying
;
Zhang, Xiaomin
;
Liu, Jing
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/01/08
ZMIZ1
TP53
TNFSF15
TL1A
IBD
Polymorphism
Leukamenin F suppresses liver fibrogenesis by inhibiting both hepatic stellate cell proliferation and extracellular matrix production
期刊论文
ACTA PHARMACOLOGICA SINICA, 2010, 卷号: 31, 期号: 7, 页码: 839-848
作者:
Liu, Qiong
;
Wang, Xu
;
Zhang, Yu
;
Li, Chen-jing
;
Hu, Li-hong
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/01/08
Leukamenin F
liver fibrosis
carbon tetrachloride
hepatic stellate cells
Akt
collagen
Effects of huperzine A on memory deficits and neurotrophic factors production after transient cerebral ischemia and reperfusio'n in mice
期刊论文
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2006, 卷号: 83, 期号: 4, 页码: 603-611
作者:
Wang, Zhi-fei
;
Tang, Li-li
;
Yan, Han
;
Wang, Yu-jun
;
Tang, Xi-can
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
Huperzine A
acetylcholinesterase inhibitor
transient cerebral ischemia and reperfusion
learning and memory
nerve growth factor
brain-derived neurotrophic factor
transforming growth factor-beta(1)
mitogen-activated protein kinase/extracellular signal-regulated kinase
Feitai, a Chinese herbal medicine, reduces transforming growth factor-beta 1 and monocyte chemoattractant PROTEIN-1 expression in bleomycin-induced lung fibrosis in mice
期刊论文
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2005, 卷号: 32, 期号: 12, 页码: 1071-1077
作者:
Shen, Y
;
Zhao, HL
;
Du, J
;
Li, YT
;
Tan, F
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/01/08
bleomycin
Feitai
lung fibrosis
mice
monocyte chemoattractant protein-1
transforming growth factor-beta 1
The therapeutic effects of bosentan and valsartan on renal interstitial fibrosis of chronic aristolochic acid nephropathy
期刊论文
National Medical Journal of China, 2005, 卷号: 85, 期号: 37, 页码: 2601-2606
作者:
ZHANG Cong
;
CHEN Yipu
;
DONG Hongrui
;
QIU Changbin
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/01/08
Aristolochic acid
Angiotensin Ⅱ
Endothelin-1
Nephritis
interstitial
The preliminary study of intervention role of enalapril and bosentan in rats with diabetic nephropathy
期刊论文
Chinese Journal of Diabetes, 2004, 卷号: 12, 期号: 6, 页码: 437-441
作者:
Cheng Hong
;
Tian Xuefei
;
Dong Hongrui
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/01/08
Diabetic nephropathy
Collagen
Transforming growth factor-beta
Plasminogen activator inhibitor-1
Tissue inhibitor of matrix metalloproteinase-1
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