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科研机构
上海药物研究所 [32]
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期刊论文 [32]
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2021 [2]
2020 [1]
2019 [5]
2018 [7]
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Oxidized Low-Density Lipoprotein Links Hypercholesterolemia and Bladder Cancer Aggressiveness by Promoting Cancer Stemness
期刊论文
CANCER RESEARCH, 2021, 卷号: 81, 期号: 22, 页码: 5720-5732
作者:
Yang, Lin
;
Sun, Jingya
;
Li, Meiqian
;
Long, Yiming
;
Zhang, Dianzheng
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2022/01/04
Rational drug design of benzothiazole-based derivatives as potent signal transducer and activator of transcription 3 (STAT3) signaling pathway inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 216, 页码: 20
作者:
Gao, Dingding
;
Jin, Nan
;
Fu, Yixian
;
Zhu, Yueyue
;
Wang, Yujie
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2021/06/11
STAT3 signaling pathway
Benzothiazole
Rational design
Antitumor activity
Molecular docking
Quantitative Proteomics Reveals the Protective Effects of Huangqi Decoction Against Acute Cholestatic Liver Injury by Inhibiting the NF-kappa B/IL-6/STAT3 Signaling Pathway
期刊论文
JOURNAL OF PROTEOME RESEARCH, 2020, 卷号: 19, 期号: 2, 页码: 677-687
作者:
Wu, Jia-Sheng
;
Liu, Qian
;
Fang, Shan-Hua
;
Liu, Xing
;
Zheng, Min
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2020/07/01
intrahepatic cholestasis
Huangqi decoction
proteomics
NF-kappa B
IL-6
STAT3
3-Deoxy-2 beta,16-dihydroxynagilactone E, a natural compound from Podocarpus nagi, preferentially inhibits JAK2/STAT3 signaling by allosterically interacting with the regulatory domain of JAK2 and induces apoptosis of cancer cells
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 12, 页码: 1578-1586
作者:
Shan, Hui
;
Yao, Sheng
;
Ye, Yang
;
Yu, Qiang
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2020/07/01
JAK/STAT
3-deoxy-2 beta,16-dihydroxynagilactone E
tyrosine kinase inhibitor
allosteric inhibitor
cancer
Xanthatin inhibits STAT3 and NF-kappa B signalling by covalently binding to JAK and IKK kinases
期刊论文
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2019, 卷号: 23, 期号: 6, 页码: 4301-4312
作者:
Liu, Man
;
Xiao, Cheng-qian
;
Sun, Ming-wei
;
Tan, Min-jia
;
Hu, Li-hong
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2020/07/01
covalent interaction
IKK inhibitor
JAK inhibitor
natural compound
2-Ethoxystypandrone, a novel small-molecule STAT3 signaling inhibitor from Polygonum cuspidatum, inhibits cell growth and induces apoptosis of HCC cells and HCC Cancer stem cells
期刊论文
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2019, 卷号: 19, 页码: 13
作者:
Li, Wuguo
;
Zhang, Qing
;
Chen, Kaotan
;
Sima, Zhenhua
;
Liu, Jingli
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2020/07/01
Polygonum cuspidatum
2-Ethoxystypandrone
Hepatocellular carcinoma
Cancer stem cells
STAT3 signaling pathway
Cancer stemness inhibitor
3deoxy216dihydroxynagilactoneeanaturalcompoundfrompodocarpusnagipreferentiallyinhibitsjak2stat3signalingbyallostericallyinteractingwiththeregulatorydomainofjak2andinducesapoptosisofcancercells
期刊论文
actapharmacologicasinica, 2019, 卷号: 40, 期号: 12, 页码: 1578
作者:
Shan Hui
;
Yao Sheng
;
Ye Yang
;
Yu Qiang
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2020/07/01
JAK/STAT
3-deoxy-2β
16-dihydroxynagilactone E
tyrosine kinase inhibitor
allosteric inhibitor
cancer
3-Deoxy-2β,16-dihydroxynagilactone E, a natural compound from Podocarpus nagi, preferentially inhibits JAK2/ STAT3 signaling by allosterically interacting with the regulatory domain of JAK2 and induces apoptosis of cancer cells
期刊论文
中国药理学报:英文版, 2019, 卷号: 40.0, 期号: 012, 页码: 1578
作者:
Hui Shan
;
Sheng Yao
;
Yang Ye
;
Qiang Yu
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2020/12/24
JAK/STAT
3-deoxy-2β,16-dihydroxynagilactone
E
tyrosine
kinase
inhibitor
allosteric
inhibitor
cancer
BF211, a derivative of bufalin, enhances the cytocidal effects in multiple myeloma cells by inhibiting the IL-6/JAK2/STAT3 pathway
期刊论文
International immunopharmacology, 2018, 卷号: 64, 页码: 24-32
作者:
Wu, Xiao-Yu
;
Tian, Fang
;
Su, Min-Hui
;
Wu, Min
;
Huang, Yue
收藏
  |  
浏览/下载:62/0
  |  
提交时间:2019/01/08
New tanshinone I derivatives S222 and S439 similarly inhibit topoisomerase I/II but reveal different p53-dependency in inducing G2/M arrest and apoptosis
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2018, 卷号: 154, 页码: 255-264
作者:
Tian, Qian-Ting
;
Ding, Chun-Yong
;
Song, Shan-Shan
;
Wang, Ying-Qing
;
Zhang, Ao
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2019/01/08
Tanshinone-1
S222
S439
Anticancer targets
DNA topoisomerases
P53
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