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科研机构
上海药物研究所 [52]
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期刊论文 [52]
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2021 [2]
2020 [1]
2019 [5]
2018 [5]
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PARP14 inhibits microglial activation via LPAR5 to promote post-stroke functional recovery
期刊论文
AUTOPHAGY, 2021, 卷号: 17, 期号: 10, 页码: 2905-2922
作者:
Tang, Ying
;
Liu, Jinchang
;
Wang, Yu
;
Yang, Li
;
Han, Bing
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2022/01/04
Autophagy
functional recovery
ischemic stroke
lysophosphatidic acid receptor 5
microglial activation
poly (ADP-ribose) polymerase 14
A novel tricyclic BTK inhibitor suppresses B cell responses and osteoclastic bone erosion in rheumatoid arthritis
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 12
作者:
Liu, Yu-ting
;
Ding, Hui-hua
;
Lin, Ze-min
;
Wang, Que
;
Chen, Li
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2021/05/24
rheumatoid arthritis
BTK inhibitors
B cells
macrophages
RANKL
osteoclastogenesis
DW14006 as a direct AMPK alpha 1 activator improves pathology of AD model mice by regulating microglial phagocytosis and neuroinflammation
期刊论文
BRAIN BEHAVIOR AND IMMUNITY, 2020, 卷号: 90, 页码: 55-69
作者:
Lv, Jianlu
;
Wang, Wei
;
Zhu, Xialin
;
Xu, Xiaoju
;
Yan, Qiuying
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2020/12/21
Alzheimer'sdisease
Microglia
AMPK alpha 1
DW14006
Phagocytosis
Neuro-inflammation
Selective activation of TWIK-related acid-sensitive K+ 3 subunit-containing channels is analgesic in rodent models
期刊论文
SCIENCE TRANSLATIONAL MEDICINE, 2019, 卷号: 11, 期号: 519, 页码: 12
作者:
Liao, Ping
;
Qiu, Yunguang
;
Mo, Yiqing
;
Fu, Jie
;
Song, Zhenpeng
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2020/07/01
Nitazoxanide, an anti-parasitic drug, efficiently ameliorates learning and memory impairments in AD model mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 10, 页码: 1279-1291
作者:
Fan, Lei
;
Qiu, Xiao-xia
;
Zhu, Zhi-yuan
;
Lv, Jian-lu
;
Lu, Jian
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/07/01
Alzheimer's disease
nitazoxanide
autophagy
inflammation
APP/PS1 transgenic mice
Development of Small-Molecules Targeting Receptor Activator of Nuclear Factor-kappa B Ligand (RANKL)-Receptor Activator of Nuclear Factor-kappa B (RANK) Protein-Protein Interaction by Structure-Based Virtual Screening and Hit Optimization
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 11, 页码: 5370-5381
作者:
Jiang, Min
;
Peng, Lei
;
Yang, Kai
;
Wang, Tianqi
;
Yan, Xueming
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/07/01
Xanthatin inhibits STAT3 and NF-kappa B signalling by covalently binding to JAK and IKK kinases
期刊论文
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2019, 卷号: 23, 期号: 6, 页码: 4301-4312
作者:
Liu, Man
;
Xiao, Cheng-qian
;
Sun, Ming-wei
;
Tan, Min-jia
;
Hu, Li-hong
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2020/07/01
covalent interaction
IKK inhibitor
JAK inhibitor
natural compound
Sulfated polysaccharide JCS1S2 inhibits angiogenesis via targeting VEGFR2/VEGF and blocking VEGFR2/Erk/VEGF signaling
期刊论文
Carbohydrate Polymers, 2019, 卷号: 207, 页码: 502-509
作者:
Wang, Zheng
;
Jin, Can
;
Li, Xueying
;
Ding, Kan
收藏
  |  
浏览/下载:78/0
  |  
提交时间:2019/01/08
A Novel Rhein Derivative Modulates Bone Formation and Resorption and Ameliorates Estrogen-Dependent Bone Loss
期刊论文
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2018
作者:
Jiang, Min
;
Wang, Tianqi
;
Yan, Xueming
;
Liu, Zhuochao
;
Yan, Yufei
收藏
  |  
浏览/下载:105/0
  |  
提交时间:2019/01/08
STAT3 activation confers trastuzumab-emtansine (T-DM1) resistance in HER2-positive breast cancer
期刊论文
CANCER SCIENCE, 2018, 卷号: 109, 期号: 10, 页码: 3305-3315
作者:
Wang, Lei
;
Wang, Quanren
;
Gao, Mingzhao
;
Fu, Li
;
Li, Yun
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2019/01/08
drug resistance
leukemia inhibitory factor receptor
secreted factor
STAT3
trastuzumab-emtansine
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