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科研机构
上海药物研究所 [12]
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期刊论文 [12]
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2021 [1]
2011 [1]
2009 [2]
2006 [5]
2005 [1]
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Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439
期刊论文
ACS INFECTIOUS DISEASES, 2021, 卷号: 7, 期号: 7, 页码: 1885-1893
作者:
Shackleford, David M.
;
Chiu, Francis C. K.
;
Katneni, Kasiram
;
Blundell, Scott
;
McLaren, Jenna
收藏
  |  
浏览/下载:61/0
  |  
提交时间:2021/11/04
OZ439 (artefenomel)
malaria
metabolite identification
cytochrome P450 metabolism
cytochrome P450 inhibition
time-dependent inhibition
Pharmacophore-based discovery of FXR-agonists. Part II: Identification of bioactive triterpenes from Ganoderma lucidum
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2011, 卷号: 19, 期号: 22, 页码: 6779-6791
作者:
Grienke, Ulrike
;
Mihaly-Bison, Judit
;
Schuster, Daniela
;
Afonyushkin, Taras
;
Binder, Markus
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
Farnesoid X receptor
Ganoderma lucidum
Lanostane triterpenes
Ganoderic acids
Molecular modeling
Virtual screening
Natural products
Huperzine A protects isolated rat brain mitochondria against beta-amyloid peptide
期刊论文
FREE RADICAL BIOLOGY AND MEDICINE, 2009, 卷号: 46, 期号: 11, 页码: 1454-1462
作者:
Gao, Xin
;
Zheng, Chun Yan
;
Yang, Ling
;
Tang, Xi Can
;
Zhang, Hai Yan
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/01/08
Huperzine A
beta-Amyloid peptide
Mitochondria
Oxidative phosphorylation
Free radicals
Engineering of cytochrome P450 3A4 for enhanced peroxide-mediated substrate oxidation using directed evolution and site-directed mutagenesis
期刊论文
DRUG METABOLISM AND DISPOSITION, 2006, 卷号: 34, 期号: 12, 页码: 1958-1965
作者:
Kumar, Santosh
;
Liu, Hong
;
Halpert, James R.
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  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
Pharmacokinetics and metabolism of the flavonoid scutellarin in humans after a single oral administration
期刊论文
DRUG METABOLISM AND DISPOSITION, 2006, 卷号: 34, 期号: 8, 页码: 1345-1352
作者:
Chen, Xiaoyan
;
Cui, Liang
;
Duan, Xiaotao
;
Ma, Bin
;
Zhong, Dafang
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/01/08
Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine
期刊论文
ACTA PHARMACOLOGICA SINICA, 2006, 卷号: 27, 期号: 1, 页码: 1-26
作者:
Wang, R
;
Yan, H
;
Tang, XC
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/01/08
huperzine A
Alzheimer disease
acetylcholinesterase
cholinesterase inhibitors
cognitive enhancer
neuroprotect agents
oxidative stress
apoptosis
progressinstudiesofhuperzineaanaturalcholinesteraseinhibitorfromchineseherbalmedicine
期刊论文
actapharmacologicasinica, 2006, 卷号: 27, 期号: 1, 页码: 1
作者:
Rui Wang
;
Han Yan
;
Xican Tang
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2020/07/01
RAT PHEOCHROMOCYTOMA CELLS
NERVE GROWTH-FACTOR
AMYLOID PRECURSOR PROTEIN
SPATIAL WORKING-MEMORY
LONG-TERM POTENTIATION
EXPERIMENTAL COGNITIVE IMPAIRMENT
DISSOCIATED HIPPOCAMPAL-NEURONS
ALZHEIMERS-DISEASE THERAPY
OXYGEN-GLUCOSE DEPRIVATION
CENTRAL CHOLINERGIC SYSTEM
huperzine A
Alzheimer disease
acetylcholinesterase
cholinesterase inhibitors
cognitive enhancer
neuroprotect agents
oxidative stress
apoptosis
Neuroprotective effects of huperzine A - A natural cholinesterase inhibitor for the treatment of Alzheimer's disease
期刊论文
NEUROSIGNALS, 2005, 卷号: 14, 期号: 1-2, 页码: 71-82
作者:
Wang, R
;
Tang, XC
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
huperzine A
Alzheimer's disease
acetylcholinesterase
cholinesterase inhibitor
cognitive enhancer
neuroprotection
oxidative stress
beta-amyloid
amyloid precursor protein
cerebral ischemia
apoptosis
apoptotic-related gene
mitochondria
glutamate
NMDA receptor
potassium current
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