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科研机构
上海药物研究所 [108]
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期刊论文 [106]
会议论文 [2]
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2021 [5]
2019 [4]
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5-Aminonaphthalene derivatives as selective nonnucleoside nuclear receptor binding SET domain-protein 2 (NSD2) inhibitors for the treatment of multiple myeloma
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 222, 页码: 19
作者:
Wang, Shuni
;
Yang, Hong
;
Su, Mingbo
;
Lian, Fulin
;
Cong, Zhanqing
收藏
  |  
浏览/下载:82/0
  |  
提交时间:2021/11/04
NSD2
Methyltransferase
HTS
Multiple myeloma
5-Aminonaphthalene derivatives
Inhibitor
A systematic strategy integrating solid-phase extraction, full scan range splitting, mass defect filter and precursor ion list for comprehensive metabolite profiling of Danqi Tongmai tablet in rats
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021, 卷号: 198, 页码: 9
作者:
Li, Zhen-wei
;
Wei, Wen-long
;
Li, Hao-jv
;
Wu, Shi-fei
;
Huang, Yong
收藏
  |  
浏览/下载:81/0
  |  
提交时间:2021/05/24
Metabolite profiling
Solid-phase extraction
Mass defect filter
Precursor ion list
Danqi Tongmai tablet
SL010110, a lead compound, inhibits gluconeogenesis via SIRT2-p300-mediated PEPCK1 degradation and improves glucose homeostasis in diabetic mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 13
作者:
Ren, Yu-ran
;
Ye, Yang-liang
;
Feng, Ying
;
Xu, Ti-fei
;
Shen, Yu
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2021/05/24
SL010110
gluconeogenesis
primary mouse hepatocytes
PEPCK1
acetylation
degradation
Challenges and stepwise fit-for-purpose optimization for bioanalyses of remdesivir metabolites nucleotide monophosphate and triphosphate in mouse tissues using LC-MS/MS
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021, 卷号: 194, 页码: 10
作者:
Hu, Wenjuan
;
Chang, Lu
;
Ke, Changqiang
;
Xie, Yuanchao
;
Shen, Jingshan
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2021/05/24
Remdesivir
Nucleotide monophosphate
Nucleotide triphosphate
Stability
Recovery
LC-MS/MS
Novel Plasma miRNAs as Biomarkers and Therapeutic Targets of Alzheimer's Disease at the Prodromal Stage
期刊论文
JOURNAL OF ALZHEIMERS DISEASE, 2021, 卷号: 83, 期号: 2, 页码: 779-790
作者:
He, Haining
;
Liu, An
;
Zhang, Wei
;
Yang, Huanqing
;
Zhang, Minmin
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2021/11/04
Alzheimer's disease
biomarkers
microRNAs
mild cognitive impairment
Nature brings new avenues to the therapy of central nervous system diseases-An overview of possible treatments derived from natural products
期刊论文
SCIENCE CHINA-LIFE SCIENCES, 2019, 卷号: 62, 期号: 10, 页码: 1332-1367
作者:
Zhang, Junchi
;
He, Yang
;
Jiang, Xiangrui
;
Jiang, Hualiang
;
Shen, Jingshan
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2020/07/01
natural products
traditional Chinese medicine
central nervous system diseases
treatment
Klyflaccilides A and B, Diterpenoids with 6/5/8/3 Fused Tetracyclic Carbon Skeleton from the Hainan Soft Coral Klyxum flaccidum
期刊论文
ORGANIC LETTERS, 2019, 卷号: 21, 期号: 14, 页码: 5660-5664
作者:
Li, Geng
;
Li, Heng
;
Tang, Wei
;
Guo, Yue-Wei
;
Li, Xu-Wen
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2020/07/01
Inhibition of MAPK/ERK pathway promotes oligodendrocytes generation and recovery of demyelinating diseases
期刊论文
GLIA, 2019, 卷号: 67, 期号: 7, 页码: 1320-1332
作者:
Suo, Na
;
Guo, Yu-e
;
He, Bingqing
;
Gu, Haifeng
;
Xie, Xin
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2020/07/01
differentiation
ERK
MAPK
MEK inhibitor
myelin
oligodendrocyte
oligodendrocyte progenitor cell
remyelination
Structure-Based Survey of the Binding Modes of BACE1 Inhibitors
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2019, 卷号: 10, 期号: 2, 页码: 880-889
作者:
Hu, Hangchen
;
Chen, Zhaoqiang
;
Xu, Xiang
;
Xuo, Yechun
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2020/07/01
BACE1
Alzheimer's disease
inhibitor
ligand binding mode
subsite
substructure
A pectin from fruits of Lycium barbarum L. decreases Beta-amyloid peptide production through modulating APP processing
期刊论文
CARBOHYDRATE POLYMERS, 2018, 卷号: 201, 页码: 65-74
作者:
Zhou, Lishuang
;
Liao, Wenfeng
;
Zeng, Hui
;
Yao, Yanli
;
Chen, Xia
收藏
  |  
浏览/下载:158/0
  |  
提交时间:2019/01/08
Lycium barbarum L.
Pectin
A beta(42)
Alzheimer's disease
Amyloid precursor protein processing
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