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浏览/检索结果: 共6条，第1-6条 帮助 限定条件 专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Cryo-EM structures of PI3K alpha reveal conformational changes during inhibition and activation 期刊论文 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118, 期号: 45, 页码: 9 作者:  Liu, Xiao;  Yang, Su;  Hart, Jonathan R.;  Xu, Yingna;  Zou, Xinyu 收藏  |  浏览/下载：41/0  |  提交时间：2022/01/04 phosphoinositide 3-kinase (PI3K)  activation  inhibition  activity-dependent conformational changes   Membrane metallo-endopeptidase mediates cellular senescence induced by oncogenic PIK3CA(H1047R) accompanied with pro-tumorigenic secretome 期刊论文 INTERNATIONAL JOURNAL OF CANCER, 2019, 卷号: 145, 期号: 3, 页码: 817-829 作者:  Liu, Xue-Ling;  Liu, Jia-Li;  Xu, Yi-Chao;  Zhang, Xi;  Wang, Yu-Xiang 收藏  |  浏览/下载：15/0  |  提交时间：2020/07/01 PI3K alpha  membrane metallo-endopeptidase  senescence  macrophage  breast cancer   High-throughput screening campaigns against a PI3K alpha isoform bearing the H1047R mutation identified potential inhibitors with novel scaffolds 期刊论文 ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 11, 页码: 1816-1822 作者:  Wang, Jia;  Gong, Grace Qun;  Zhou, Yan;  Lee, Woo-Jeong;  Buchanan, Christina Maree 收藏  |  浏览/下载：86/0  |  提交时间：2019/01/08 high throughput screening  PI3 kinase  PI3K alpha H1047R  inhibitors  molecular modeling   Synthesis, biological evaluation and structure-activity relationship of a novel class of PI3K alpha H1047R mutant inhibitors 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 707-719 作者:  Zhang, Ning;  Yu, Zhimei;  Yang, Xiaohong;  Zhou, Yan;  Wang, Jia 收藏  |  浏览/下载：88/0  |  提交时间：2019/01/08 Anticancer drug  Phosphatidylinositol 3-kinase  Structure-activity relationship   New Insights into PI3K Inhibitor Design using X-ray Structures of PI3K alpha Complexed with a Potent Lead Compound 期刊论文 SCIENTIFIC REPORTS, 2017, 卷号: 7 作者:  Yang, Xiuyan;  Zhang, Xi;  Huang, Min;  Song, Kun;  Li, Xuefen 收藏  |  浏览/下载：22/0  |  提交时间：2019/01/08 WJD008, a Dual Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin Inhibitor, Prevents PI3K Signaling and Inhibits the Proliferation of Transformed Cells with Oncogenic PI3K Mutant 期刊论文 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2010, 卷号: 334, 期号: 3, 页码: 830-838 作者:  Li, Ting;  Wang, Jia;  Wang, Xiang;  Yang, Na;  Chen, Si-meng 收藏  |  浏览/下载：11/0  |  提交时间：2019/01/08