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科研机构
上海药物研究所 [86]
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期刊论文 [85]
学位论文 [1]
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2020 [2]
2019 [3]
2018 [3]
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Development of Bisindole-Substituted Aminopyrazoles as Novel GSK-3 beta Inhibitors with Suppressive Effects against Microglial Inflammation and Oxidative Neurotoxicity
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2020, 卷号: 11, 期号: 20, 页码: 3398-3408
作者:
Liu, Jian-Guo
;
Zhao, Danfeng
;
Gong, Qi
;
Bao, Fengxia
;
Chen, Wen-Wen
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2021/05/24
Glycogen synthase kinase-3
bisindole-substituted aminopyrazoles
Alzheimer's disease
oxidative neurotoxicity
microglial inflammation
A proton-coupled organic cation antiporter is involved in the blood-brain barrier transport of Aconitum alkaloids
期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2020, 卷号: 252, 页码: 9
作者:
Cong, Jiaojiao
;
Ruan, Yiling
;
Lyu, Qinglin
;
Qin, Xiaohui
;
Qi, Xinming
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2020/07/01
Aconitum alkaloids
Blood-brain barrier
Proton-coupled organic cation antiporter
hCMEC/D3 cells
Drug transport
Caffeic acid reduces A53T alpha-synuclein by activating JNK/Bcl-2-mediated autophagy in vitro and improves behaviour and protects dopaminergic neurons in a mouse model of Parkinson's disease
期刊论文
PHARMACOLOGICAL RESEARCH, 2019, 卷号: 150, 页码: 14
作者:
Zhang, Yu
;
Wu, Qimei
;
Zhang, Lei
;
Wang, Qing
;
Yang, Zexian
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2020/07/01
Caffeic acid
A53T
Parkinson's disease
Autophagy
JNK
Novel dihydroartemisinin dimer containing nitrogen atoms inhibits growth of endometrial cancer cells and may correlate with increasing intracellular peroxynitrite
期刊论文
SCIENTIFIC REPORTS, 2019, 卷号: 9, 页码: 14
作者:
Zhu, Yan
;
Klausen, Christian
;
Zhou, Jieyun
;
Guo, Xiangjie
;
Zhang, Yu
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  |  
浏览/下载:81/0
  |  
提交时间:2020/07/01
Discovery of new multifunctional selective acetylcholinesterase inhibitors: structure-based virtual screening and biological evaluation
期刊论文
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2019, 卷号: 33, 期号: 5, 页码: 521-530
作者:
Jiang, Cheng-Shi
;
Ge, Yong-Xi
;
Cheng, Zhi-Qiang
;
Song, Jia-Li
;
Wang, Yin-Yin
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2020/07/01
AChE inhibitor
Pharmacophore model
Molecular docking
Anti-A aggregation
Neuroprotective activity
An arabinogalactan from fruits of Lycium barbarum L. inhibits production and aggregation of A beta(42)
期刊论文
CARBOHYDRATE POLYMERS, 2018, 卷号: 195, 页码: 643-651
作者:
Zhou, Lishuang
;
Liao, Wenfeng
;
Chen, Xia
;
Yue, Han
;
Li, Saijuan
收藏
  |  
浏览/下载:105/0
  |  
提交时间:2019/01/08
Lycium barbarum
Polysaccharide
A beta(42)
Alzheimer's disease
HPLC-ECD and TDDFT-ECD study of hexahydropyrrolo[1,2-a]quinoline derivatives
期刊论文
CHIRALITY, 2018, 卷号: 30, 期号: 7, 页码: 866-874
作者:
Toth, Laszlo
;
Mandi, Attila
;
Varadi, Daniel
;
Kovacs, Tibor
;
Szabados, Anna
收藏
  |  
浏览/下载:54/0
  |  
提交时间:2019/01/08
[1,5]-hydride shift
C-H activation
density functional theory
relative and absolute configuration
Characterization of a pectin from Lonicera japonica Thunb. and its inhibition effect on A beta(42) aggregation and promotion of neuritogenesis
期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2018, 卷号: 107, 页码: 112-120
作者:
Liu, Qin
;
Fang, Jianping
;
Wang, Peipei
;
Du, Zhenyun
;
Li, Yanling
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/01/08
Rhamnogalacturonan I (RG-I) pectic polysaccharide
Lonicera japonica Thunb.
A beta(42) aggregation
Neuritogenesis
Alzheimer's disease
Nuclear Accumulation of Histone Deacetylase 4 (HDAC4) Exerts Neurotoxicity in Models of Parkinson's Disease
期刊论文
MOLECULAR NEUROBIOLOGY, 2017, 卷号: 54, 期号: 9, 页码: 6970-6983
作者:
Wu, Qimei
;
Yang, Xiaoyu
;
Zhang, Lei
;
Zhang, Yu
;
Feng, Linyin
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2019/01/08
HDAC4
alpha-Synuclein
Neuroprotection
Parkinson's disease
PKC
Research advances in the treatment of Alzheimer's disease with polysaccharides from traditional Chinese medicine
期刊论文
CHINESE JOURNAL OF NATURAL MEDICINES, 2017, 卷号: 15, 期号: 9, 页码: 641-652
作者:
Liu Qin
;
Wang Shun-Chun
;
Ding Kan
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
Alzheimer's disease
Polysaccharides
Traditional Chinese medicine
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