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科研机构
上海药物研究所 [46]
内容类型
期刊论文 [46]
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2020 [2]
2019 [3]
2018 [5]
2017 [3]
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DGAT1 inhibitors protect pancreatic beta-cells from palmitic acid-induced apoptosis
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 8
作者:
Huang, Jun-shang
;
Guo, Bin-bin
;
Wang, Gai-hong
;
Zeng, Li-min
;
Hu, You-hong
收藏
  |  
浏览/下载:57/0
  |  
提交时间:2020/12/24
type 2 diabetes
DGAT1 inhibitors
pancreatic beta-cells
apoptosis
ER stress
inflammation
Preparation and evaluation of PEGylated asiatic acid nanostructured lipid carriers on anti-fibrosis effects
期刊论文
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2020, 卷号: 46, 期号: 1, 页码: 57-69
作者:
Chen, Xiaoxiao
;
Zhang, Yawen
;
Zhao, Pengfei
;
Chen, Yan
;
Zhou, Yunli
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2020/07/01
Asiatic acid
PEGylated nanostructured lipid carriers
anti-liver fibrosis
liver targeting strategy
pharmacokinetics
Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives (THPBs) as proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators for the treatment of hyperlipidemia
期刊论文
ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 6, 页码: 1216-1230
作者:
Wu, Chenglin
;
Xi, Cong
;
Tong, Junhua
;
Zhao, Jing
;
Jiang, Hualiang
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2020/07/01
PCSK9
Tetrahydroprotoberberine derivatives
Low-density lipoprotein cholesterol
Lipid-lowering
PCSK9 expression
Low-density lipoprotein receptor
Total cholesterol
Hyperlipidemia hamster
designsynthesisandbiologicalevaluationofnoveltetrahydroprotoberberinederivativesthpbsasproproteinconvertasesubtilisinkexintype9pcsk9modulatorsforthetreatmentofhyperlipidemia
期刊论文
actapharmaceuticasinicab, 2019, 卷号: 9, 期号: 6, 页码: 1216
作者:
Wu Chenglin
;
Xi Cong
;
Tong Junhua
;
Zhao Jing
;
Jiang Hualiang
收藏
  |  
浏览/下载:52/0
  |  
提交时间:2020/07/01
DOPAMINE D-1
BERBERINE
EXPRESSION
INHIBITORS
IDENTIFICATION
CHOLESTEROL
MUTATIONS
LDLR
PCSK9
Tetrahydroprotoberberine derivatives
Low-density lipoprotein cholesterol
Lipid-lowering
PCSK9 expression
Low-density lipoprotein receptor
Total cholesterol
Hyperlipidemia hamster
Concentration Dependent Effects of Ca~(2+) and Mg~(2+) on the Phosphatidylethanolamine-Phosphatidylglycerol Bilayer
期刊论文
Acta Physica-Chimica Sinica, 2019, 卷号: 35, 期号: 8, 页码: 840
作者:
Zhang Tao
;
Qiu Yunguang
;
Luo Qichao
;
Cheng Xi
;
Zhao Lifen
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2020/12/24
二价阳离子
磷脂双分子层
动态光散射
Zeta电势
分子动力学模拟
相互作用
High-throughput screening campaigns against a PI3K alpha isoform bearing the H1047R mutation identified potential inhibitors with novel scaffolds
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 11, 页码: 1816-1822
作者:
Wang, Jia
;
Gong, Grace Qun
;
Zhou, Yan
;
Lee, Woo-Jeong
;
Buchanan, Christina Maree
收藏
  |  
浏览/下载:86/0
  |  
提交时间:2019/01/08
high throughput screening
PI3 kinase
PI3K alpha H1047R
inhibitors
molecular modeling
Effect of Medium-chain Fatty Acid-sensing Receptor GPR84 on Glucose and Lipid Metabolism in Mice
期刊论文
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2018, 卷号: 45, 期号: 8, 页码: 853-864
作者:
Fang You-Chen
;
Zheng Yang
;
Zheng Qing
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2019/01/08
GPR84
medium-chain fatty acid-sensing receptor
obesity
lipid metabolism
hypercholesterolemia
Linderane Suppresses Hepatic Gluconeogenesis by Inhibiting the cAMP/PKA/CREB Pathway Through Indirect Activation of PDE 3 via ERK/STAT3
期刊论文
FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9
作者:
Xie, Wei
;
Ye, Yangliang
;
Feng, Ying
;
Xu, Tifei
;
Huang, Suling
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2019/01/08
cAMP
gluconeogenesis
linderane
phosphodiesterase
type 2 diabetes
highthroughputscreeningcampaignsagainstapi3kisoformbearingtheh1047rmutationidentifiedpotentialinhibitorswithnovelscaffolds
期刊论文
actapharmacologicasinica, 2018, 卷号: 039, 期号: 011, 页码: 1816
作者:
Wang Jia
;
Gong Grace Qun
;
Zhou Yan
;
Lee Woojeong
;
Buchanan Christina Maree
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2020/07/01
脚手架
屏蔽
识别
产量
运动
类脂化合物
混合物
新陈代谢
High-throughput screening campaigns against a PI3Kα isoform bearing the H1047R mutation identified potential inhibitors with novel scaffolds
期刊论文
中国药理学报:英文版, 2018, 卷号: 39.0, 期号: 011, 页码: 1816
作者:
Jia Wang
;
Grace Qun Gong
;
Yan Zhou
;
WooJeong Lee
;
Christina Maree Buchanan
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2020/12/24
脚手架
屏蔽
识别
产量
运动
类脂化合物
混合物
新陈代谢
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