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科研机构
上海药物研究所 [37]
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期刊论文 [37]
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2021 [3]
2019 [2]
2018 [3]
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Metabolic map of the antiviral drug podophyllotoxin provides insights into hepatotoxicity
期刊论文
XENOBIOTICA, 2021, 页码: 13
作者:
Sun, Dongxue
;
Gao, Xiaoxia
;
Wang, Qiao
;
Krausz, Kristopher W.
;
Fang, Zhongze
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2021/11/04
CYP
podophyllotoxin metabolism
liver microsomes
recombinant drug-metabolizing enzymes
hepatic and intestinal toxicity
Acid-activatible micelleplex delivering siRNA-PD-L1 for improved cancer immunotherapy of CDK4/6 inhibition
期刊论文
CHINESE CHEMICAL LETTERS, 2021, 卷号: 32, 期号: 6, 页码: 1929-1936
作者:
Gao, Jing
;
Zhang, Hanwu
;
Zhou, Fengqi
;
Hou, Bo
;
Chen, Meiwan
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2021/08/17
Cancer immunotherapy
siRNA delivery
Acid-activatible micelleplex
CDK4
6 inhibitor
PD-L1 knockdown
Chitosan oligosaccharide modified liposomes enhance lung cancer delivery of paclitaxel
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Miao, Yun-qiu
;
Chen, Ming-shu
;
Zhou, Xin
;
Guo, Lin-miao
;
Zhu, Jing-jing
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  |  
浏览/下载:43/0
  |  
提交时间:2021/05/24
lung cancer
antitumor
chitosan oligosaccharide
liposomes
paclitaxel
drug delivery
nanomedicine
Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives (THPBs) as proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators for the treatment of hyperlipidemia
期刊论文
ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 6, 页码: 1216-1230
作者:
Wu, Chenglin
;
Xi, Cong
;
Tong, Junhua
;
Zhao, Jing
;
Jiang, Hualiang
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2020/07/01
PCSK9
Tetrahydroprotoberberine derivatives
Low-density lipoprotein cholesterol
Lipid-lowering
PCSK9 expression
Low-density lipoprotein receptor
Total cholesterol
Hyperlipidemia hamster
designsynthesisandbiologicalevaluationofnoveltetrahydroprotoberberinederivativesthpbsasproproteinconvertasesubtilisinkexintype9pcsk9modulatorsforthetreatmentofhyperlipidemia
期刊论文
actapharmaceuticasinicab, 2019, 卷号: 9, 期号: 6, 页码: 1216
作者:
Wu Chenglin
;
Xi Cong
;
Tong Junhua
;
Zhao Jing
;
Jiang Hualiang
收藏
  |  
浏览/下载:52/0
  |  
提交时间:2020/07/01
DOPAMINE D-1
BERBERINE
EXPRESSION
INHIBITORS
IDENTIFICATION
CHOLESTEROL
MUTATIONS
LDLR
PCSK9
Tetrahydroprotoberberine derivatives
Low-density lipoprotein cholesterol
Lipid-lowering
PCSK9 expression
Low-density lipoprotein receptor
Total cholesterol
Hyperlipidemia hamster
Pharmacokinetics and tissue distribution of eupatilin and its metabolite in rats by an HPLC-MS/MS method
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2018, 卷号: 159, 页码: 113-118
作者:
Wang, Xixiao
;
Ren, Jie
;
Zhu, Shixing
;
Ren, Guoqing
;
Wang, Lei
收藏
  |  
浏览/下载:86/0
  |  
提交时间:2019/01/08
Eupatilin
E-7-G
HPLC-MS/MS
Pharmacokinetic
Tissue distribution
Rapid, reliable, and sensitive detection of adenosine deaminase activity by UHPLC-Q-Orbitrap HRMS and its application to inhibitory activity evaluation of traditional Chinese medicines
期刊论文
Journal of pharmaceutical and biomedical analysis, 2018, 卷号: 153, 页码: 175-181
作者:
Qi, Shenglan
;
Guan, Huida
;
Deng, Gang
;
Yang, Tao
;
Cheng, Xuemei
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2019/01/08
Rational Design of Tumor Microenvironment-Activated Micelles for Programed Targeting of Breast Cancer Metastasis
期刊论文
ADVANCED FUNCTIONAL MATERIALS, 2018, 卷号: 28, 期号: 8
作者:
He, Bin
;
Tan, Tao
;
Wang, Hong
;
Hu, Haiyan
;
Wang, Zhiwan
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/01/08
cabazitaxel
cancer metastasis
micelles
programed targeting
tumor microenvironment
The requirement of SEPT2 and SEPT7 for migration and invasion in human breast cancer via MEK/ERK activation
期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 38, 页码: 61587-61600
作者:
Zhang, Nianzhu
;
Liu, Lu
;
Fan, Ning
;
Zhang, Qian
;
Wang, Weijie
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
septin
forchlorfenuron
breast cancer
invasion
MAPK
Discovery and Rational Design of Natural-Product-Derived 2-Phenyl-3,4-dihydro-2H-benzo[f]chromen-3-amine Analogs as Novel and Potent Dipeptidyl Peptidase 4 (DPP-4) Inhibitors for the Treatment of Type 2 Diabetes
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 59, 期号: 14, 页码: 6772-6790
作者:
Li, Shiliang
;
Xu, Hongling
;
Cui, Shichao
;
Wu, Fangshu
;
Zhang, Youli
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/01/08
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