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科研机构
上海药物研究所 [155]
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期刊论文 [155]
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2021 [23]
2020 [23]
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STING inhibitor ameliorates LPS-induced ALI by preventing vascular endothelial cells-mediated immune cells chemotaxis and adhesion
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 12
作者:
Wu, Bing
;
Xu, Meng-meng
;
Fan, Chen
;
Feng, Chun-lan
;
Lu, Qiu-kai
收藏
  |  
浏览/下载:61/0
  |  
提交时间:2022/01/18
acute lung injury
STING
vascular endothelial cells
inflammatory cytokines
chemokines
chemotaxis
Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Li, Teng-teng
;
Peng, Cheng
;
Wang, Ji-qiu
;
Xu, Zhi-jian
;
Su, Ming-bo
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2022/01/18
DPP4
distal mutation
enzymatic activity
molecular dynamics simulation
structure-function mechanism
Structures of full-length glycoprotein hormone receptor signalling complexes
期刊论文
NATURE, 2021, 页码: 24
作者:
Duan, Jia
;
Xu, Peiyu
;
Cheng, Xi
;
Mao, Chunyou
;
Croll, Tristan
收藏
  |  
浏览/下载:55/0
  |  
提交时间:2021/11/04
Structural basis of ketamine action on human NMDA receptors
期刊论文
NATURE, 2021, 卷号: 596, 期号: 7871, 页码: 301-+
作者:
Zhang, Youyi
;
Ye, Fei
;
Zhang, Tongtong
;
Lv, Shiyun
;
Zhou, Liping
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2021/11/04
Discovery of potential small molecular SARS-CoV-2 entry blockers targeting the spike protein
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Wang, Lin
;
Wu, Yan
;
Yao, Sheng
;
Ge, Huan
;
Zhu, Ya
收藏
  |  
浏览/下载:91/0
  |  
提交时间:2021/11/04
SARS-CoV-2
natural products
virtual screening
spike protein
protein-protein interaction modulators
Histone deacetylase inhibitor givinostat attenuates nonalcoholic steatohepatitis and liver fibrosis
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 13
作者:
Huang, He-ming
;
Fan, Shi-jie
;
Zhou, Xiao-ru
;
Liu, Yan-jun
;
Li, Xiao
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2021/11/04
nonalcoholic steatohepatitis
inflammation
histone deacetylase inhibitor
givinostat
epigenetics
Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Zhou, Yu-bo
;
Zhang, Yang-ming
;
Huang, Hong-hui
;
Shen, Li-jing
;
Han, Xiao-feng
收藏
  |  
浏览/下载:98/0
  |  
提交时间:2021/11/04
multiple myeloma
HDAC inhibitor
bisthianostat
pharmacodynamics
pharmacokinetics
phase 1a clinical trial
antitumor drug
Structural basis for genome packaging, retention, and ejection in human cytomegalovirus
期刊论文
NATURE COMMUNICATIONS, 2021, 卷号: 12, 期号: 1, 页码: 14
作者:
Li, Zhihai
;
Pang, Jingjing
;
Dong, Lili
;
Yu, Xuekui
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2021/11/04
Discovery of SARS-CoV-2-E channel inhibitors as antiviral candidates
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 7
作者:
Wang, Yi
;
Fang, Sui
;
Wu, Yan
;
Cheng, Xi
;
Zhang, Lei-ke
收藏
  |  
浏览/下载:110/0
  |  
提交时间:2021/08/17
SARS-CoV-2
envelope protein (2-E)
cation channel
high-throughput screening (HTS)
anti-virus
Itraconazole and rifampicin, as CYP3A modulators but not P-gp modulators, affect the pharmacokinetics of almonertinib and active metabolite HAS-719 in healthy volunteers
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Liu, Lu
;
Li, Wei
;
Yang, Le
;
Guo, Zi-tao
;
Xue, Hao
收藏
  |  
浏览/下载:80/0
  |  
提交时间:2021/08/17
almonertinib
itraconazole
rifampicin
drug metabolism
drug interaction
CYP3A
P-gp
pharmacokinetics
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