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科研机构
上海药物研究所 [263]
内容类型
期刊论文 [259]
会议论文 [3]
学位论文 [1]
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2021 [14]
2020 [23]
2019 [17]
2018 [23]
2017 [17]
2016 [16]
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Chemistry [8]
Pharmacolo... [8]
Biochemist... [1]
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Cocktail polysaccharides isolated from Ecklonia kurome against the SARS-CoV-2 infection
期刊论文
CARBOHYDRATE POLYMERS, 2022, 卷号: 275, 页码: 8
作者:
Zhang, Shihai
;
Pei, Rongjuan
;
Li, Meixia
;
Su, Haixia
;
Sun, Hao
收藏
  |  
浏览/下载:71/0
  |  
提交时间:2021/12/16
COVID-19
SARS-CoV-2
Angiotensin converting enzyme 2 (ACE2)
3CL protease
Ecklonia kurome Okam
Polysaccharide
5-Aminonaphthalene derivatives as selective nonnucleoside nuclear receptor binding SET domain-protein 2 (NSD2) inhibitors for the treatment of multiple myeloma
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 222, 页码: 19
作者:
Wang, Shuni
;
Yang, Hong
;
Su, Mingbo
;
Lian, Fulin
;
Cong, Zhanqing
收藏
  |  
浏览/下载:80/0
  |  
提交时间:2021/11/04
NSD2
Methyltransferase
HTS
Multiple myeloma
5-Aminonaphthalene derivatives
Inhibitor
Discovery of SARS-CoV-2-E channel inhibitors as antiviral candidates
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 7
作者:
Wang, Yi
;
Fang, Sui
;
Wu, Yan
;
Cheng, Xi
;
Zhang, Lei-ke
收藏
  |  
浏览/下载:103/0
  |  
提交时间:2021/08/17
SARS-CoV-2
envelope protein (2-E)
cation channel
high-throughput screening (HTS)
anti-virus
Identification of Novel Fused Heteroaromatics-Based MALT1 Inhibitors by High-Throughput Screening to Treat B Cell Lymphoma
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 13, 页码: 9217-9237
作者:
Liang, Xuewu
;
Sun, Chenxia
;
Li, Chunpu
;
Yu, Haolan
;
Wei, Xiaohui
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2021/08/17
The inhibitory effect of 225 frequently-used traditional Chinese medicines for CYP3A4 metabolic enzyme by isoform-specific probe
期刊论文
FITOTERAPIA, 2021, 卷号: 152, 页码: 5
作者:
Wei, Wenlong
;
Li, Zhenwei
;
Li, Hao-jv
;
An, Yaling
;
Qu, Hua
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2021/08/17
Inhibitory effect
Frequently-used traditional Chinese medicines
Isoform-specific probe
Discovery of Novel Allosteric Modulators Targeting an Extra-Helical Binding Site of GLP-1R Using Structure- and Ligand-Based Virtual Screening
期刊论文
BIOMOLECULES, 2021, 卷号: 11, 期号: 7, 页码: 14
作者:
Zhou, Qingtong
;
Guo, Wanjing
;
Dai, Antao
;
Cai, Xiaoqing
;
Vass, Marton
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2021/08/17
GLP-1R
virtual screening
allosteric modulator
drug discovery
molecular docking
BoxCar increases the depth and reproducibility of diabetic urinary proteome analysis
期刊论文
PROTEOMICS CLINICAL APPLICATIONS, 2021, 页码: 12
作者:
Ye, Shu
;
Zhai, Linhui
;
Hu, Hao
;
Tan, Minjia
;
Du, Shichun
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2021/08/17
BoxCar
DDA
mass spectrometry
urinary proteomics
Histone deacetylase inhibitor givinostat alleviates liver fibrosis by regulating hepatic stellate cell activation
期刊论文
MOLECULAR MEDICINE REPORTS, 2021, 卷号: 23, 期号: 5, 页码: 12
作者:
Huang, He-Ming
;
Zhou, Xiao-Ru
;
Liu, Yan-Jun
;
Fan, Shi-Jie
;
Liao, Li-Ping
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2021/05/24
liver fibrosis
hepatic stellate cell
histone deacetylase inhibitor
epigenetics
givinostat
Design, synthesis and pharmacological evaluation of tricyclic derivatives as selective RXFP4 agonists
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 110, 页码: 17
作者:
Lin, Lin
;
Lin, Guangyao
;
Zhou, Qingtong
;
Bathgate, Ross A. D.
;
Gong, Grace Qun
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2021/08/17
Synthesis
Structure-activity relationship
Relaxin family peptide receptor 4
Selective agonist
Molecular docking
Natural product 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose is a reversible inhibitor of glyceraldehyde 3-phosphate dehydrogenase
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 13
作者:
Li, Wen
;
Liao, Li-ping
;
Song, Ning
;
Liu, Yan-jun
;
Ding, Yi-luan
收藏
  |  
浏览/下载:81/0
  |  
提交时间:2021/06/11
glyceraldehyde 3-phosphate dehydrogenase
1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose
hydrogen deuterium exchange mass spectrometry
reversible inhibitor
glycolysis
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