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科研机构
上海药物研究所 [93]
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期刊论文 [93]
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2021 [6]
2020 [4]
2019 [2]
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Theoretical study and application of 2-phenyl-1,3,4-thiadiazole derivatives with optical and inhibitory activity against SHP1
期刊论文
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2021, 页码: 14
作者:
Zhang, Chun
;
Sun, Yi-Tao
;
Gao, Li-Xin
;
Feng, Bo
;
Yan, Xue
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2022/01/18
Discovery of a novel DDRs kinase inhibitor XBLJ-13 for the treatment of idiopathic pulmonary fibrosis
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Dong, Ying
;
Tang, Bi-xi
;
Wang, Qi
;
Zhou, Li-wei
;
Li, Cong
收藏
  |  
浏览/下载:79/0
  |  
提交时间:2022/01/04
idiopathic pulmonary fibrosis
DDRs
kinase inhibitor
indazole derivatives
XBLJ-13
nintedanib
bleomycin-induced pulmonary fibrosismouse model
Synthesis and biological evaluation of 2,5-diaryl-1,3,4-oxadiazole derivatives as novel Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) inhibitors
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 116, 页码: 13
作者:
Meng, Xiang-Dong
;
Gao, Li-Xin
;
Wang, Zhi-Jia
;
Feng, Bo
;
Zhang, Chun
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2021/12/01
2,5-diphenyl-1,3,4-oxadiazole derivatives
SHP2
Inhibitors
Structure-activity relationships (SAR)
Synthesis of 5-Phenyl-1,3,4-thiadiazole Derivatives and Their Biochemical Evaluation against Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 1 (SHP1)
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 41, 期号: 8, 页码: 3097-3105
作者:
Yu Lijie
;
Feng Bo
;
Wang Zhijia
;
Gao Lixin
;
Zhang Chun
收藏
  |  
浏览/下载:242/0
  |  
提交时间:2021/11/04
5-phenyl-1,3,4-thiadiazole derivatives
Src homology 2 domain-containing protein tyrosine phosphatase 1 (SHP1)
inhibitors
structure-activity relationships
Discovery of 1,5-Dihydro-4H-imidazol-4-one Derivatives as Potent, Selective Antagonists of CXC Chemokine Receptor 2
期刊论文
ACS MEDICINAL CHEMISTRY LETTERS, 2021, 卷号: 12, 期号: 5, 页码: 836-845
作者:
Che, Jinxin
;
Wang, Zhilong
;
Shen, Zheyuan
;
Zhuang, Weihao
;
Ying, Huazhou
收藏
  |  
浏览/下载:61/0
  |  
提交时间:2021/08/17
cancer metastasis
CXCR1
CXCR2
selectivity
antagonist
1,5-dihydro-4H-imidazol-4-one
Structures of the human dopamine D3 receptor-G(i) complexes
期刊论文
MOLECULAR CELL, 2021, 卷号: 81, 期号: 6, 页码: 1147-+
作者:
Xu, Peiyu
;
Huang, Sijie
;
Mao, Chunyou
;
Krumm, Brian E.
;
Zhou, X. Edward
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2021/05/24
Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet-induced hepatic steatosis and insulin resistance by elevating IL-18 levels
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 卷号: 295, 期号: 31, 页码: 10842-10856
作者:
Liu, Wen
;
Yin, Ye
;
Wang, Meijing
;
Fan, Ting
;
Zhu, Yuyu
收藏
  |  
浏览/下载:237/0
  |  
提交时间:2020/12/24
Src homology 2 domain containing tyrosine phosphatase-2 (SHP2)
hepatic steatosis
insulin resistance
caspase-1
interleukin 18 (IL-18)
fatty liver
metabolic disorder
inflammation
cytokine signaling
caspase 1 (CASP1)
tyrosine-protein phosphatase (tyrosine phosphatase)
macrophage
Synthesis and biological evaluation of heterocyclic bis-aryl amides as novel Src homology 2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 11, 页码: 5
作者:
Satheeshkumar, Rajendran
;
Zhu, Rui
;
Feng, Bo
;
Huang, Chao
;
Gao, Ya
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2020/07/01
Heterocyclic bis-aryl amides
PTP1B
SHP2
Inhibitors
Structure-activity relationships (SAR)
Synthesis, antifungal activity and potential mechanism of fusidic acid derivatives possessing amino-terminal groups
期刊论文
FUTURE MEDICINAL CHEMISTRY, 2020, 卷号: 12, 期号: 9, 页码: 763-774
作者:
Cao, Yucheng
;
Ni, Jingxuan
;
Ji, Wentao
;
Shang, Kangle
;
Liang, Kaicheng
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2020/12/24
antifungal activity
fusidic acid
homology modeling
molecular docking
molecular dynamics simulations
Phytochemical and biological studies on rare and endangered plants endemic to China. Part XIV. Structurally diverse terpenoids from the twigs and needles of the endangered plant Picea brachytyla
期刊论文
PHYTOCHEMISTRY, 2020, 卷号: 169, 页码: 11
作者:
Jiang, Wei
;
Xiong, Juan
;
Zang, Yi
;
Li, Junmin
;
Osman, Ezzat E. A.
收藏
  |  
浏览/下载:86/0
  |  
提交时间:2020/07/01
Picea brachytyla (Franch.) E.Pritz.
Pinaceae
Endangered plant
Terpenoids
Brachytylins
ATP citrate lyase (ACL)
SHP2 tyrosine phosphatase
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