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科研机构
上海药物研究所 [77]
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期刊论文 [77]
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2021 [4]
2020 [3]
2019 [3]
2018 [9]
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Constitutive signal bias mediated by the human GHRHR splice variant 1
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118, 期号: 40, 页码: 10
作者:
Cong, Zhaotong
;
Zhou, Fulai
;
Zhang, Chao
;
Zou, Xinyu
;
Zhang, Huibing
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2021/12/01
class B1 GPCR
receptor bias
cancer
cell proliferation
Synthesis and Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitory Activity Evaluation of Novel Arylaminoacetylhydrazone Derivatives Containing Carbazole Moiety
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 41, 期号: 8, 页码: 3157-3170
作者:
Li Yingjun
;
Lin Ledi
;
Jin Kun
;
Gao Lixin
;
Sheng Li
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/11/04
protein tyrosine phosphatase 1B (PTP1B) inhibitor
carbazole
arylaminoacetylhydrazone
synthesis
molecular docking
Design, synthesis and pharmacological evaluation of bicyclic and tetracyclic pyridopyrimidinone analogues as new KRAS(G12C) inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 213, 页码: 17
作者:
Xiao, Xuanzheng
;
Lai, Mengzhen
;
Song, Zilan
;
Geng, Meiyu
;
Ding, Jian
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2021/05/24
KRAS
Covalent inhibitor
Pyridopyrimidinone
Antiproliferative effect
Scaffold hopping
Synthesis of new derivatives of alepterolic acid via click chemistry
期刊论文
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, 2021, 卷号: 86, 期号: 10, 页码: 917-925
作者:
Jin, X. I. N.
;
Cao, Jianguo
;
Zhao, Qingjie
;
Wang, Qi
;
Guo, Hongmei
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2021/11/04
diterpenoid
1,2,3-triazole
structural modification
Tumor-Activated Size-Enlargeable Bioinspired Lipoproteins Access Cancer Cells in Tumor to Elicit Anti-Tumor Immune Responses
期刊论文
ADVANCED MATERIALS, 2020, 页码: 11
作者:
Li, Jie
;
Wang, Hong
;
Wang, Yuqi
;
Gong, Xiang
;
Xu, Xiaoxuan
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2020/12/24
anti-tumor immune responses
cancer immunotherapy
lipoproteins
oxaliplatin
tumor targeting
MiR-629-5p promotes the invasion of lung adenocarcinoma via increasing both tumor cell invasion and endothelial cell permeability
期刊论文
ONCOGENE, 2020, 页码: 16
作者:
Li, Yu
;
Zhang, Huibiao
;
Fan, Lei
;
Mou, Jiahui
;
Yin, Yue
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2020/07/01
Global characterization of proteome and lysine methylome features in EZH2 wild-type and mutant lymphoma cell lines
期刊论文
JOURNAL OF PROTEOMICS, 2020, 卷号: 213, 页码: 10
作者:
Hao, Bingbing
;
Sun, Mingwei
;
Zhang, Min
;
Zhao, Xiaoxiao
;
Zhao, Lei
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2020/07/01
Lysine methylome
Quantitative proteomics
EZH2
Diffuse large B cell lymphoma
PTM crosstalk
Inhibition of G9a by a small molecule inhibitor, UNC0642, induces apoptosis of human bladder cancer cells
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 8, 页码: 1076-1084
作者:
Cao, Yue-peng
;
Sun, Jing-ya
;
Li, Mei-qian
;
Dong, Yu
;
Zhang, Yuan-heng
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/07/01
human urinary bladder cancer
G9a
UNC0642
apoptosis
Design, Synthesis and Pharmacological Evaluation of Novel Hsp90N-terminal Inhibitors Without Induction of Heat Shock Response
期刊论文
CHEMISTRYOPEN, 2019, 卷号: 8, 期号: 3, 页码: 344-353
作者:
Liu, Peng
;
Chen, Xiangling
;
Zhu, Jianming
;
Li, Bo
;
Chen, Zhaoqiang
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2020/07/01
autophagy
Hsp72
Hsp90 inhibitor
triazines
antitumor activity
inhibitionofg9abyasmallmoleculeinhibitorunc0642inducesapoptosisofhumanbladdercancercells
期刊论文
actapharmacologicasinica, 2019, 卷号: 40, 期号: 8, 页码: 1076
作者:
Cao Yuepeng
;
Sun Jingya
;
Li Meiqian
;
Dong Yu
;
Zhang Yuanheng
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2020/07/01
METHYLATION
BIX-01294
PROLIFERATION
SURVIVAL
EHMT2
P53
human urinary bladder cancer
G9a
UNC0642
apoptosis
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