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CORC

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Species differences in the CYP3A-catalyzed metabolism of TPN729, a novel PDE5 inhibitor 期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 9
作者:  Tian, Qian-qian;  Zhu, Yun-ting;  Diao, Xing-xing;  Zhang, Xiang-lei;  Xu, Ye-chun
收藏  |  浏览/下载：69/0  |  提交时间：2020/12/24
Pao Pereira Extract Attenuates Testosterone-Induced Benign Prostatic Hyperplasia in Rats by inhibiting 5 alpha-Reductase 期刊论文
SCIENTIFIC REPORTS, 2019, 卷号: 9, 页码: 10
作者:  Liu, Jiakuan;  Fang, Tian;  Li, Meiqian;  Song, Yuting;  Li, Junzun
收藏  |  浏览/下载：34/0  |  提交时间：2020/07/01
Pharmacokinetics-Driven Optimization of 4(3H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 10, 页码: 4979-4990
作者:  Wang, Zhen;  Jiang, Xiangrui;  Zhang, Xianglei;  Tian, Guanghui;  Yang, Rulei
收藏  |  浏览/下载：39/0  |  提交时间：2020/07/01
Characterization of TPN729 metabolites in humans using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry 期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2016, 卷号: 117, 页码: 217-226
作者:  Zhu, Yunting;  Li, Liang;  Deng, Pan;  Chen, Xiaoyan;  Zhong, Dafang
收藏  |  浏览/下载：23/0  |  提交时间：2019/01/08
Structure-Based Discovery of PDEs Inhibitors 期刊论文
CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2016, 卷号: 16, 期号: 9, 页码: 917-933
作者:  Li, Li;  Chen, Wuyan;  Chen, Tiantian;  Ren, Jing;  Xu, Yechun
收藏  |  浏览/下载：18/0  |  提交时间：2019/01/08
Preclinical pharmacokinetics of TPN729MA, a novel PDE5 inhibitor, and prediction of its human pharmacokinetics using a PBPK model 期刊论文
ACTA PHARMACOLOGICA SINICA, 2015, 卷号: 36, 期号: 12, 页码: 1528-1536
作者:  Gao, Zhi-wei;  Zhu, Yun-ting;  Yu, Ming-ming;  Zan, Bin;  Liu, Jia
收藏  |  浏览/下载：30/0  |  提交时间：2019/01/08
preclinicalpharmacokineticsoftpn729maanovelpde5inhibitorandpredictionofitshumanpharmacokineticsusingapbpkmodel 期刊论文
actapharmacologicasinica, 2015, 卷号: 36, 期号: 12, 页码: 1528
作者:  Gao Zhiwei;  Zhu Yunting;  Yu Mingming;  Zan Bin;  Liu Jia
收藏  |  浏览/下载：3/0  |  提交时间：2020/07/01
Thermodynamic and Structural Characterization of Halogen Bonding in Protein-Ligand Interactions: A Case Study of PDE5 and Its Inhibitors 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2014, 卷号: 57, 期号: 8, 页码: 3588-3593
作者:  Ren, Jing;  He, Yang;  Chen, Wuyan;  Chen, Tiantian;  Wang, Guan
收藏  |  浏览/下载：18/0  |  提交时间：2019/01/08
The Selectivity and Potency of the New PDE5 Inhibitor TPN729MA 期刊论文
JOURNAL OF SEXUAL MEDICINE, 2013, 卷号: 10, 期号: 11, 页码: 2790-2797
作者:  Wang, Zhen;  Zhu, Difeng;  Yang, Xiaochun;  Li, Jianfeng;  Jiang, Xiangrui
收藏  |  浏览/下载：24/0  |  提交时间：2019/01/08
Synthesis of 1,7-dimethoxy-2-hydroxyxanthone, a natural product with potential activity on erectile dysfunction 期刊论文
CHINESE CHEMICAL LETTERS, 2013, 卷号: 24, 期号: 6, 页码: 515-517
作者:  Liu, Wen-Jing;  Mei, De-Sheng;  Duan, Wen-Hu
收藏  |  浏览/下载：18/0  |  提交时间：2019/01/08

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