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CORC

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Simultaneous determination of sutetinib and its active metabolite sutetinibN-oxide in human plasma by liquid chromatography-tandem mass spectrometry: Evaluation of plasma stability 期刊论文
BIOMEDICAL CHROMATOGRAPHY, 2020, 页码: 9
作者:  Qiu, Yanan;  Tang, Chongzhuang;  Li, Ranran;  Cao, Sumin;  Zhang, Yuqiang
收藏  |  浏览/下载：31/0  |  提交时间：2020/12/24
Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance 期刊论文
MOLECULAR CANCER, 2020, 卷号: 19, 期号: 1, 页码: 15
作者:  Zhang, Tao;  Qu, Rong;  Chan, Shingpan;  Lai, Mengzhen;  Tong, Linjiang
收藏  |  浏览/下载：43/0  |  提交时间：2020/07/01
Alflutinib (AST2818), primarily metabolized by CYP3A4, is a potent CYP3A4 inducer 期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 11
作者:  Liu, Xiao-yun;  Guo, Zi-tao;  Chen, Zhen-dong;  Zhang, Yi-fan;  Zhou, Jia-lan
收藏  |  浏览/下载：80/0  |  提交时间：2020/07/01
A Novel Allosteric Inhibitor of Phosphoglycerate Mutase 1 Suppresses Growth and Metastasis of Non-Small-Cell Lung Cancer 期刊论文
CELL METABOLISM, 2019, 卷号: 30, 期号: 6, 页码: 1107-+
作者:  Huang, Ke;  Liang, Qian;  Zhou, Ye;  Jiang, Lu-lu;  Gu, Wei-ming
收藏  |  浏览/下载：79/0  |  提交时间：2020/07/01
Synthesis and Biological Evaluation of Oxopyrido[2,3-d] Pyrimidine-7-ones Derivatives as Covalent L85812/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors 期刊论文
LETTERS IN DRUG DESIGN & DISCOVERY, 2019, 卷号: 16, 期号: 8, 页码: 826-834
作者:  Niu, Ao;  Wang, Yang;  Yang, Yushe;  Wei, Jianhai;  Ding, Jian
收藏  |  浏览/下载：12/0  |  提交时间：2020/07/01
Design, Synthesis, and Biological Evaluation of Pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-diones as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 13, 页码: 5609-5622
作者:  Hao, Yongjia;  Lyu, Jiankun;  Qu, Rong;  Tong, Yi;  Sun, Deheng
收藏  |  浏览/下载：66/0  |  提交时间：2019/01/08
YL143, a novel mutant selective irreversible EGFR inhibitor, overcomes EGFR(L858R, T790M)-mutant resistance in vitro and in vivo 期刊论文
CANCER MEDICINE, 2018, 卷号: 7, 期号: 4, 页码: 1430-1439
作者:  Zhang, Zhang;  Zou, Jian;  Yu, Lei;  Luo, Jinfeng;  Li, Yan
收藏  |  浏览/下载：71/0  |  提交时间：2019/01/08
Structure-based design and synthesis of 2,4-diaminopyrimidines as EGFR L858R/T790M selective inhibitors for NSCLC 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 140, 页码: 510-527
作者:  Chen, Lingfeng;  Fu, Weitao;  Feng, Chen;  Qu, Rong;  Tong, Linjiang
收藏  |  浏览/下载：57/0  |  提交时间：2019/01/08
Structure-Guided Design of C4-alkyl-1,4-dihydro-2H-pyrimido[4,5-d][1,3]oxazin-2-ones as Potent and Mutant-Selective Epidermal Growth Factor Receptor (EGFR) L858R/T790M Inhibitors 期刊论文
SCIENTIFIC REPORTS, 2017, 卷号: 7
作者:  Hao, Yongjia;  Lyu, Jiankun;  Qu, Rong;  Sun, Deheng;  Zhao, Zhenjiang
收藏  |  浏览/下载：34/0  |  提交时间：2019/01/08
Discovery and Structural Optimization of N5-Substituted 6,7-Dioxo-6,7-dihydropteridines as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 59, 期号: 15, 页码: 7111-7124
作者:  Hao, Yongjia;  Wang, Xia;  Zhang, Tao;  Sun, Deheng;  Tong, Yi
收藏  |  浏览/下载：32/0  |  提交时间：2019/01/08

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