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CORC

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Discovery and Development of a Potent, Selective, and Orally Bioavailable CHK1 Inhibitor Candidate: 5-((4-((3-Amino-3-methylbutyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)picolinonitrile 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 20, 页码: 15069-15090
作者:  Jin, Tingting;  Xu, Lei;  Wang, Peipei;  Hu, Xiaobei;  Zhang, Runyuan
收藏  |  浏览/下载：23/0  |  提交时间：2022/01/04
Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 19, 页码: 14647-14663
作者:  Han, Xu;  Song, Ning;  Saidahmatov, Abdusaid;  Wang, Peipei;  Wang, Yong
收藏  |  浏览/下载：17/0  |  提交时间：2021/12/16
The Novel Chinese Medicine JY5 Formula Alleviates Hepatic Fibrosis by Inhibiting the Notch Signaling Pathway 期刊论文
FRONTIERS IN PHARMACOLOGY, 2021, 卷号: 12, 页码: 15
作者:  Fu, Yadong;  Xiao, Zhun;  Tian, Xiaoting;  Liu, Wei;  Xu, Zhou
收藏  |  浏览/下载：30/0  |  提交时间：2022/01/04
Discovery of High-Affinity Inhibitors of the BPTF Bromodomain 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 16, 页码: 12075-12088
作者:  Lu, Tian;  Lu, Haibo;  Duan, Zhe;  Wang, Jun;  Han, Jie
收藏  |  浏览/下载：38/0  |  提交时间：2021/11/04
Discovery of pyrrolo[2,3-d]pyrimidine derivatives as potent Axl inhibitors: Design, synthesis and biological evaluation 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 220, 页码: 18
作者:  Xu, Dandan;  Sun, Deqiao;  Wang, Wei;  Peng, Xia;  Zhan, Zhengsheng
收藏  |  浏览/下载：46/0  |  提交时间：2021/08/17
Discovery of a novel, potent and selective small-molecule inhibitor of PD-1/PD-L1 interaction with robust in vivo anti-tumour efficacy 期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2021, 页码: 20
作者:  Liu, Chenglong;  Zhou, Feilong;  Yan, Ziqin;  Shen, Lian;  Zhang, Xichen
收藏  |  浏览/下载：26/0  |  提交时间：2021/06/11
Discovery of novel inhibitors against main protease (Mpro) of SARS-CoV-2 via virtual screening and biochemical evaluation 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 110, 页码: 8
作者:  Guo, Sheng;  Xie, Hang;  Lei, Yu;  Liu, Bin;  Zhang, Li
收藏  |  浏览/下载：34/0  |  提交时间：2021/08/17
Development of hedgehog pathway inhibitors by epigenetically targeting GLI through BET bromodomain for the treatment of medulloblastoma 期刊论文
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 2, 页码: 488-504
作者:  Liu, Xiaohua;  Zhang, Yu;  Li, Yalei;  Wang, Juan;  Ding, Huaqian
收藏  |  浏览/下载：30/0  |  提交时间：2021/05/24
GPR52 Antagonist Reduces Huntingtin Levels and Ameliorates Huntington's Disease-Related Phenotypes 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 2, 页码: 941-957
作者:  Wang, Congcong;  Zhang, Yu-Fang;  Guo, Shimeng;  Zhao, Quan;  Zeng, Yanping
收藏  |  浏览/下载：21/0  |  提交时间：2021/05/24
Synthesis of 2-ethoxycarbonylthieno[2,3-b]quinolines in biomass-derived solvent gamma-valerolactone and their biological evaluation against protein tyrosine phosphatase 1B 期刊论文
RSC ADVANCES, 2021, 卷号: 11, 期号: 6, 页码: 3216-3220
作者:  Mu, Xu-Yang;  Wang, Zhi-Jia;  Feng, Bo;  Xu, Lei;  Gao, Li-Xin
收藏  |  浏览/下载：14/0  |  提交时间：2021/05/24

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