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科研机构
上海药物研究所 [13]
内容类型
期刊论文 [13]
发表日期
2020 [2]
2019 [1]
2018 [3]
2016 [1]
2015 [1]
2014 [1]
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专题:上海药物研究所
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Discovery and biological evaluation of N-(3-(7-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-methyl-2-oxo-2H-pyrimido[4,5-d][1,3]oxazin-1(4H)-yl)phenyl)acrylamide as potent Bruton's tyrosine kinase inhibitors
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 卷号: 41, 期号: 3, 页码: 415-422
作者:
Lai, Meng-zhen
;
Song, Pei-ran
;
Dou, Dou
;
Diao, Yan-yan
;
Tong, Lin-jiang
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2020/07/01
B cell receptor
Bruton's tyrosine kinase
ibrutinib
small-molecule inhibitor
B cell malignancies
discoveryandbiologicalevaluationofn372methoxy44methylpiperazin1ylphenylamino4methyl2oxo2hpyrimido45d13oxazin14hylphenylacrylamideaspotentbrutonstyrosinekinaseinhibitors
期刊论文
actapharmacologicasinica, 2020, 卷号: 41, 期号: 3, 页码: 415
作者:
Lai Mengzhen
;
Song Peiran
;
Dou Dou
;
Diao Yanyan
;
Tong Linjiang
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2020/07/01
B cell receptor
Bruton’s tyrosine kinase
ibrutinib
small-molecule inhibitor
B cell malignancies
Discovery of New Selective Butyrylcholinesterase (BChE) Inhibitors with Anti-A beta Aggregation Activity: Structure-Based Virtual Screening, Hit Optimization and Biological Evaluation
期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 14, 页码: 21
作者:
Jiang, Cheng-Shi
;
Ge, Yong-Xi
;
Cheng, Zhi-Qiang
;
Wang, Yin-Yin
;
Tao, Hong-Rui
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2020/07/01
selective BChE inhibitor
virtual screening
structural optimization
molecular dynamics
anti-A beta aggregation
Discovery and optimization of a series of 3-substituted indazole derivatives as multi-target kinase inhibitors for the treatment of lung squamous cell carcinoma
期刊论文
European journal of medicinal chemistry, 2018, 卷号: 163, 页码: 671-689
作者:
Wang, Qi
;
Dai, Yang
;
Ji, Yinchun
;
Shi, Huanyu
;
Guo, Zuhao
收藏
  |  
浏览/下载:89/0
  |  
提交时间:2019/01/08
Molecular-docking-guided design and synthesis of new IAA-tacrine hybrids as multifunctional AChE/BChE inhibitors
期刊论文
Bioorganic chemistry, 2018, 卷号: 83, 页码: 277-288
作者:
Cheng, Zhi-Qiang
;
Zhu, Kong-Kai
;
Zhang, Juan
;
Song, Jia-Li
;
Muehlmann, Luis Alexandre
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2019/01/08
Extra Sugar on Vancomycin: New Analogues for Combating Multidrug-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococci
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 1, 页码: 286-304
作者:
Guan, Dongliang
;
Chen, Feifei
;
Xiong, Lun
;
Tang, Feng
;
Faridoon
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2019/01/08
Design, synthesis and in vitro activity of phidianidine B derivatives as novel PTP1B inhibitors with specific selectivity
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 卷号: 26, 期号: 3, 页码: 778-781
作者:
Zhang, Li
;
Jiang, Cheng-Shi
;
Gao, Li-Xin
;
Gong, Jing-Xu
;
Wang, Zhong-Hua
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
Phidianidine
Oxadiazole derivative
PTP1B inhibitor
Specific selectivity
Docking analysis
Function-oriented synthesis
Design and synthesis of novel 1,2-dithiolan-4-yl benzoate derivatives as PTP1B inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 卷号: 25, 期号: 10, 页码: 2211-2216
作者:
Chen, Jing
;
Gao, Li-Xin
;
Gong, Jing-Xu
;
Jiang, Cheng-Shi
;
Yao, Li-Gong
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
Disulfide derivative
PTP1B inhibitor
Diabetes
Selectivity
Determination of pK(a) values of a triptolide derivative and its impurities by pressure-assisted capillary electrophoresis
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2014, 卷号: 88, 页码: 22-26
作者:
Wang, Jian-Ling
;
Xu, Xue-Jiao
;
Chen, Dong-Ying
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
Capillary electrophoresis
External pressure
pK(a)
Triptolide derivative
Impurities
Potentiometric titration
Design, synthesis, and biological evaluation of novel 2-ethyl-5-phenylthiazole-4-carboxamide derivatives as protein tyrosine phosphatase 1B inhibitors with improved cellular efficacy
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 卷号: 69, 页码: 399-412
作者:
Chen, Yue-Ting
;
Tang, Chun-Lan
;
Ma, Wei-Ping
;
Gao, Li-Xin
;
Wei, Yi
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/01/08
Protein tyrosine phosphatase 1B
Type 2 diabetes
2-Ethyl-5-phenylthiazole-4-carboxamide (PTA)
SAR
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