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科研机构
上海药物研究所 [191]
内容类型
期刊论文 [185]
会议论文 [6]
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2021 [7]
2020 [4]
2019 [8]
2018 [18]
2017 [4]
2016 [6]
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Biochemist... [9]
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The potent radioprotective agents: Novel nitronyl nitroxide radical spin-labeled resveratrol derivatives
期刊论文
FITOTERAPIA, 2021, 卷号: 155, 页码: 7
作者:
Luo, Guoying
;
Sun, Lanlan
;
Li, Heng
;
Chen, Jia
;
He, Peilan
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2021/12/01
Ionizing radiation
Resveratrol
Nitronyl nitroxide radical
Radioprotection effects
Restoring perturbed oxylipins with Danqi Tongmai Tablet attenuates acute myocardial infarction
期刊论文
PHYTOMEDICINE, 2021, 卷号: 90, 页码: 12
作者:
Zhi, Haijuan
;
Zhang, Zijia
;
Deng, Yanping
;
Yan, Bingpeng
;
Li, Zhenwei
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2021/11/04
Acute myocardial infarction
Danqi Tongmai tablet
In vivo metabolite
Oxylipin
Arachidonic acid metabolome
Homeostasis
Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439
期刊论文
ACS INFECTIOUS DISEASES, 2021, 卷号: 7, 期号: 7, 页码: 1885-1893
作者:
Shackleford, David M.
;
Chiu, Francis C. K.
;
Katneni, Kasiram
;
Blundell, Scott
;
McLaren, Jenna
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2021/11/04
OZ439 (artefenomel)
malaria
metabolite identification
cytochrome P450 metabolism
cytochrome P450 inhibition
time-dependent inhibition
Furmonertinib (Alflutinib, AST2818) is a potential positive control drug comparable to rifampin for evaluation of CYP3A4 induction in sandwich-cultured primary human hepatocytes
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 10
作者:
Wu, Ya-li
;
Xue, Ya-ru
;
Guo, Zi-tao
;
Chen, Zhen-dong
;
Ge, Xin-yu
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/08/17
furmonertinib (alflutinib
AST2818)
quantitative proteomics
sandwich-cultured human hepatocytes
Paeoniflorin ameliorates ischemic injury in rat brain via inhibiting cytochrome c/caspase3/HDAC4 pathway
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 12
作者:
Liu, Yi-fei
;
Zhang, Lei
;
Wu, Qi
;
Feng, Lin-yin
收藏
  |  
浏览/下载:69/0
  |  
提交时间:2021/06/11
ischemic brain injury
paeoniflorin
MCAO
HDAC4
cytochrome c
apoptosis
Paeoniflorin ameliorates ischemic injury in rat brain via inhibiting cytochrome c/caspase3/HDAC4 pathway
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 12
作者:
Liu, Yi-fei
;
Zhang, Lei
;
Wu, Qi
;
Feng, Lin-yin
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2021/06/11
ischemic brain injury
paeoniflorin
MCAO
HDAC4
cytochrome c
apoptosis
Functional Proliferating Human Hepatocytes: In Vitro Hepatocyte Model for Drug Metabolism, Excretion, and Toxicity
期刊论文
DRUG METABOLISM AND DISPOSITION, 2021, 卷号: 49, 期号: 4, 页码: 305-313
作者:
Qiao, Shida
;
Feng, Sisi
;
Wu, Zhitao
;
He, Ting
;
Ma, Chen
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2021/05/24
Species differences in the CYP3A-catalyzed metabolism of TPN729, a novel PDE5 inhibitor
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 9
作者:
Tian, Qian-qian
;
Zhu, Yun-ting
;
Diao, Xing-xing
;
Zhang, Xiang-lei
;
Xu, Ye-chun
收藏
  |  
浏览/下载:69/0
  |  
提交时间:2020/12/24
PDE5 inhibitor
TPN729
M3
species difference
pharmacokinetics
metabolite identification
Cordycepin inhibits pancreatic cancer cell growth in vitro and in vivo via targeting FGFR2 and blocking ERK signaling
期刊论文
CHINESE JOURNAL OF NATURAL MEDICINES, 2020, 卷号: 18, 期号: 5, 页码: 345-355
作者:
Li Xue-Ying
;
Tao Hong
;
Jin Can
;
Du Zhen-Yun
;
Liao Wen-Feng
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/07/01
Cordycepin
FGFR2
Apoptosis
Pancreatic cancer
Ras/Erk
Alflutinib (AST2818), primarily metabolized by CYP3A4, is a potent CYP3A4 inducer
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 11
作者:
Liu, Xiao-yun
;
Guo, Zi-tao
;
Chen, Zhen-dong
;
Zhang, Yi-fan
;
Zhou, Jia-lan
收藏
  |  
浏览/下载:76/0
  |  
提交时间:2020/07/01
alflutinib
AST5902
metabolism
enzyme induction
drug-drug interaction
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