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科研机构
上海药物研究所 [200]
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期刊论文 [200]
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2021 [21]
2020 [22]
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Potent and Selective RIPK1 Inhibitors Targeting Dual-Pockets for the Treatment of Systemic Inflammatory Response Syndrome and Sepsis
期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 6
作者:
Yang, Xiangbo
;
Lu, Huimin
;
Xie, Hang
;
Zhang, Binbin
;
Nie, Tianqing
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2022/01/18
Binding studies
Drug discovery
Necroptosis
RIPK1 inhibitors
Sepsis
A camptothecin-based, albumin-binding prodrug enhances efficacy and safety in vivo
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 226, 页码: 11
作者:
Cheng, Zhiyang
;
Huang, Ying
;
Shen, Qianqian
;
Zhao, Yangrong
;
Wang, Lei
收藏
  |  
浏览/下载:87/0
  |  
提交时间:2021/11/04
Cancer
beta-glucuronidase
Bioconjugation
Albumin
Camptothecin
Discovery of a novel DDRs kinase inhibitor XBLJ-13 for the treatment of idiopathic pulmonary fibrosis
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Dong, Ying
;
Tang, Bi-xi
;
Wang, Qi
;
Zhou, Li-wei
;
Li, Cong
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  |  
浏览/下载:79/0
  |  
提交时间:2022/01/04
idiopathic pulmonary fibrosis
DDRs
kinase inhibitor
indazole derivatives
XBLJ-13
nintedanib
bleomycin-induced pulmonary fibrosismouse model
Synthesis and biological evaluation of 2,5-diaryl-1,3,4-oxadiazole derivatives as novel Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) inhibitors
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 116, 页码: 13
作者:
Meng, Xiang-Dong
;
Gao, Li-Xin
;
Wang, Zhi-Jia
;
Feng, Bo
;
Zhang, Chun
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2021/12/01
2,5-diphenyl-1,3,4-oxadiazole derivatives
SHP2
Inhibitors
Structure-activity relationships (SAR)
Discovery and Development of a Potent, Selective, and Orally Bioavailable CHK1 Inhibitor Candidate: 5-((4-((3-Amino-3-methylbutyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)picolinonitrile
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 20, 页码: 15069-15090
作者:
Jin, Tingting
;
Xu, Lei
;
Wang, Peipei
;
Hu, Xiaobei
;
Zhang, Runyuan
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  |  
浏览/下载:24/0
  |  
提交时间:2022/01/04
Discovery of chiral N-2 '-aryletheryl-1 '-alkoxy-ethyl substituted arylisoquinolones with anti-inflammatory activity from the nucleophilic addition reactions of the thiophenols and oxazolinium
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 222, 页码: 11
作者:
Li, Bo
;
Li, Heng
;
Zhu, Zhengdan
;
Xiang, Caigui
;
Xu, Zhijian
收藏
  |  
浏览/下载:103/0
  |  
提交时间:2021/11/04
Anti-inflammatory activity
TNF alpha
ER beta
IBD Arylisoquinolones
5-Aminonaphthalene derivatives as selective nonnucleoside nuclear receptor binding SET domain-protein 2 (NSD2) inhibitors for the treatment of multiple myeloma
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 222, 页码: 19
作者:
Wang, Shuni
;
Yang, Hong
;
Su, Mingbo
;
Lian, Fulin
;
Cong, Zhanqing
收藏
  |  
浏览/下载:82/0
  |  
提交时间:2021/11/04
NSD2
Methyltransferase
HTS
Multiple myeloma
5-Aminonaphthalene derivatives
Inhibitor
Novel tetrahydrobenzo[b]thiophen-2-yl)urea derivatives as novel alpha-glucosidase inhibitors: Synthesis, kinetics study, molecular docking, and in vivo anti-hyperglycemic evaluation
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 115, 页码: 17
作者:
Xie, Hong-Xu
;
Zhang, Juan
;
Li, Yue
;
Zhang, Jin-He
;
Liu, Shan-Kui
收藏
  |  
浏览/下载:69/0
  |  
提交时间:2021/11/04
Tetrahydrobenzo[b]thiophen-2-yl)urea
alpha-Glucosidase inhibitors
Non-competitive inhibitor
Molecular docking
Anti-hyperglycaemic activity
Type 2 diabetes
Discovery of an M-Substituted N-Cyclopropylmethyl-7 alpha-phenyl-6,14-endoethanotetrahydronorthebaine as a Selective, Potent, and Orally Active kappa-Opioid Receptor Agonist with an Improved Central Nervous System Safety Profile
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 16, 页码: 12414-12433
作者:
He, Qian
;
Wei, Yuanyuan
;
Liu, Xiao
;
Ye, Rongrong
;
Kong, Linghui
收藏
  |  
浏览/下载:88/0
  |  
提交时间:2021/11/04
Synthesis of 5-Phenyl-1,3,4-thiadiazole Derivatives and Their Biochemical Evaluation against Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 1 (SHP1)
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 41, 期号: 8, 页码: 3097-3105
作者:
Yu Lijie
;
Feng Bo
;
Wang Zhijia
;
Gao Lixin
;
Zhang Chun
收藏
  |  
浏览/下载:243/0
  |  
提交时间:2021/11/04
5-phenyl-1,3,4-thiadiazole derivatives
Src homology 2 domain-containing protein tyrosine phosphatase 1 (SHP1)
inhibitors
structure-activity relationships
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