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科研机构
上海药物研究所 [27]
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期刊论文 [26]
会议论文 [1]
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2020 [1]
2019 [1]
2018 [6]
2017 [2]
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2015 [2]
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Neuroscien... [1]
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Polysaccharides from Lycium barbarum ameliorate amyloid pathology and cognitive functions in APP/PS1 transgenic mice
期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 卷号: 144, 页码: 1004-1012
作者:
Zhou, Yue
;
Duan, Yanhong
;
Huang, Shichao
;
Zhou, Xuan
;
Zhou, Lishuang
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2020/07/01
Lycium barbarum polysaccharides
Alzheimer's disease
Amyloid-beta
Synaptic plasticity
Neuropathology
High-resolution mapping of brain vasculature and its impairment in the hippocampus of Alzheimer's disease mice
期刊论文
NATIONAL SCIENCE REVIEW, 2019, 卷号: 6, 期号: 6, 页码: 1223-1238
作者:
Zhang, Xiaochuan
;
Yin, Xianzhen
;
Zhang, Jingjing
;
Li, Anan
;
Gong, Hui
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2020/07/01
Micro-Optical Sectioning Tomography
image optimization
Alzheimer's disease
impaired hippocampal vasculature
virtual vascular endoscopy
Cognitive Impairment and Endoplasmic Reticulum Stress Induced by Repeated Short-Term Sevoflurane Exposure in Early Life of Rats
期刊论文
FRONTIERS IN PSYCHIATRY, 2018, 卷号: 9
作者:
Shen, Fu-Yi
;
Song, Ying-Cai
;
Guo, Fei
;
Xu, Zhen-Dong
;
Li, Qian
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2019/01/08
sevoflurane
repeated exposure
cognitive dysfunction
synaptic plasticity
endoplasmic reticulum stress
A Novel 2-Phenylamino-Quinazoline-Based Compound Expands the Neural Stem Cell Pool and Promotes the Hippocampal Neurogenesis and the Cognitive Ability of Adult Mice
期刊论文
STEM CELLS, 2018, 卷号: 36, 期号: 8, 页码: 1273-1285
作者:
Lu, Hui
;
Cheng, Gang
;
Hong, Feng
;
Zhang, Lei
;
Hu, Youhong
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2019/01/08
Neural stem cells
Notch signaling pathway
Hes5
Adult hippocampal neurogenesis
Learning and memory
2-phenylamino-quinazoline
Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 12, 页码: 3117-3125
作者:
Liu, Wenwen
;
Wang, Huan
;
Li, Xiaokang
;
Xu, Yixiang
;
Zhang, Jian
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2019/01/08
Depression
Cognitive impairment
Multitarget-directed ligand
5-HT1A agonist
5-HT reuptake inhibition
ChE inhibition
GLYX-13 Ameliorates Schizophrenia-Like Phenotype Induced by MK-801 in Mice: Role of Hippocampal NR2B and DISC1
期刊论文
FRONTIERS IN MOLECULAR NEUROSCIENCE, 2018, 卷号: 11
作者:
Zhou, Dongsheng
;
Lv, Dan
;
Wang, Zhen
;
Zhang, Yanhua
;
Chen, Zhongming
收藏
  |  
浏览/下载:74/0
  |  
提交时间:2019/01/08
GLYX-13
disrupted-in-schizophrenia 1
N-methyl-D-aspartate receptor
N-methyl D-aspartate receptor subtype 2B
schizophrenia
Protopanaxadiol derivative DDPU improves behavior and cognitive deficit in AD mice involving regulation of both ER stress and autophagy
期刊论文
NEUROPHARMACOLOGY, 2018, 卷号: 130, 页码: 77-91
作者:
Guo, Xiaodan
;
Lv, Jianlu
;
Lu, Jian
;
Fan, Lei
;
Huang, Xi
收藏
  |  
浏览/下载:54/0
  |  
提交时间:2019/01/08
Alzheimer's disease
Ginseng
Autophagy
BACE1
ER stress
Amyloid beta
Apoptosis
APP/PS1 transgenic mice
Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer's Disease
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2018, 卷号: 9, 期号: 2, 页码: 328-345
作者:
Mao, Fei
;
Wang, Huan
;
Ni, Wei
;
Zheng, Xinyu
;
Wang, Manjiong
收藏
  |  
浏览/下载:56/0
  |  
提交时间:2019/01/08
Alzheimer's disease
drug repositioning
dual-target inhibitor
AChE inhibition
PDE5 inhibition
LX2343 alleviates cognitive impairments in AD model rats by inhibiting oxidative stress-induced neuronal apoptosis and tauopathy
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 8, 页码: 1104-1119
作者:
Guo, Xiao-dan
;
Sun, Guang-long
;
Zhou, Ting-ting
;
Wang, Yi-yang
;
Xu, Xin
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2019/01/08
Alzheimer's disease
LX2343
cognitive deficits
oxidative stress
tauopathy
mitochondria
GSK-3 beta inhibitor
neuroprotection
ICV-STZ rats
GTS40, an active fraction of Gou Teng-San (GTS), protects PC12 from H2O2-induced cell injury through antioxidative properties
期刊论文
CHINESE JOURNAL OF NATURAL MEDICINES, 2017, 卷号: 15, 期号: 7, 页码: 495
作者:
Chen Lei
;
Wei MengLin
;
Zhao JiaoJiao
;
Hong Hao
;
Qu Wei
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2020/12/24
BCL-2 FAMILY-MEMBERS
OXIDATIVE STRESS
APOPTOSIS
MITOCHONDRIA
ALKALOIDS
DEATH
MICE
MS
INHIBITION
CHOTOSAN
GTS40
Oxidative stress
Neuroprotective effects
Apoptosis
HPLC-QTOF-MS/MS
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