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科研机构
上海药物研究所 [39]
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期刊论文 [39]
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2021 [3]
2020 [2]
2019 [1]
2018 [4]
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Structural characteristics of Heparan sulfate required for the binding with the virus processing Enzyme Furin
期刊论文
GLYCOCONJUGATE JOURNAL, 2021, 页码: 11
作者:
Zeng, Jiaxin
;
Meng, Yuan
;
Chen, Shi-Yi
;
Zhao, Gaofeng
;
Wang, Lianchun
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2021/12/01
Furin
Heparan sulfate
Heparin
Virus infection
Carbohydrate-protein interaction
Discovery of a novel, potent and selective small-molecule inhibitor of PD-1/PD-L1 interaction with robust in vivo anti-tumour efficacy
期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2021, 页码: 20
作者:
Liu, Chenglong
;
Zhou, Feilong
;
Yan, Ziqin
;
Shen, Lian
;
Zhang, Xichen
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2021/06/11
immunotherapy
PD-1/PD-L1
TGF-beta
tumour immune microenvironment
Rational drug design of benzothiazole-based derivatives as potent signal transducer and activator of transcription 3 (STAT3) signaling pathway inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 216, 页码: 20
作者:
Gao, Dingding
;
Jin, Nan
;
Fu, Yixian
;
Zhu, Yueyue
;
Wang, Yujie
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2021/06/11
STAT3 signaling pathway
Benzothiazole
Rational design
Antitumor activity
Molecular docking
USP28 and USP25 are downregulated by Vismodegib in vitro and in colorectal cancer cell lines
期刊论文
FEBS JOURNAL, 2020, 页码: 18
作者:
Wang, Hui
;
Meng, Qian
;
Ding, Yiluan
;
Xiong, Muya
;
Zhu, Mengying
收藏
  |  
浏览/下载:87/0
  |  
提交时间:2020/12/24
colorectal cancer
HDX-MS
inhibitor
USP25
USP28
Vismodegib
Natural product piperine alleviates experimental allergic encephalomyelitis in mice by targeting dihydroorotate dehydrogenase
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2020, 卷号: 177, 页码: 15
作者:
Liu, Zehui
;
Hu, Qian
;
Wang, Wanyan
;
Lu, Sisi
;
Wu, Dang
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2020/12/24
Multiple sclerosis
DHODH
Piperine
Natural product
Inhibition of phosphodiesterase-4 attenuates murine ulcerative colitis through interference with mucosal immunity
期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2019, 卷号: 176, 期号: 13, 页码: 2209-2226
作者:
Li, Heng
;
Fan, Chen
;
Feng, Chunlan
;
Wu, Yanwei
;
Lu, Huimin
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/07/01
Scutellarin alleviates blood-retina-barrier oxidative stress injury initiated by activated microglia cells during the development of diabetic retinopathy
期刊论文
Biochemical pharmacology, 2018, 卷号: 159, 页码: 82-95
作者:
Mei, Xiyu
;
Zhang, Tianyu
;
Ouyang, Hao
;
Lu, Bin
;
Wang, Zhengtao
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2019/01/08
PBA2 exhibits potent anti-tumor activity via suppression of VEGFR2 mediated-cell proliferation and angiogenesis
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2018, 卷号: 150, 页码: 131-140
作者:
Fang, Xiaona
;
Xie, Hua
;
Luo, Min
;
Chen, Zhen
;
Wang, Fang
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2019/01/08
Angiogenesis
And-tumor activity
Multi-tyrosine kinases inhibitor
PBA2
VEGFR2
Discovery of Novel Inhibitors of Indoleamine 2,3-Dioxygenase 1 Through Structure-Based Virtual Screening
期刊论文
FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9
作者:
Zhang, Guoqing
;
Xing, Jing
;
Wang, Yulan
;
Wang, Lihao
;
Ye, Yan
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2019/01/08
indoleamine 2, 3-dioxygense
IDO1 inhibitor
virtual screening
molecular docking
hit expansion
Interaction assessments of the first S-adenosylmethionine competitive inhibitor and the essential interacting partner methylosome protein 50 with protein arginine methyltransferase 5 by combined computational methods
期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 卷号: 495, 期号: 1, 页码: 721-727
作者:
Zhu, Kongkai
;
Jiang, Cheng-Shi
;
Hu, Junchi
;
Liu, Xigong
;
Yan, Xue
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2019/01/08
PRMT5 SAM competitive inhibitor
Molecular docking
Molecular dynamics simulation
Molecular mechanics/Poisson-Boltzmann surface area
PRMT5:MEP50 interaction
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