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科研机构
上海药物研究所 [88]
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期刊论文 [82]
学位论文 [5]
会议论文 [1]
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2021 [4]
2020 [4]
2019 [2]
2018 [2]
2017 [3]
2016 [8]
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Theoretical study and application of 2-phenyl-1,3,4-thiadiazole derivatives with optical and inhibitory activity against SHP1
期刊论文
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2021, 页码: 14
作者:
Zhang, Chun
;
Sun, Yi-Tao
;
Gao, Li-Xin
;
Feng, Bo
;
Yan, Xue
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2022/01/18
Synthesis of 5-Phenyl-1,3,4-thiadiazole Derivatives and Their Biochemical Evaluation against Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 1 (SHP1)
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 41, 期号: 8, 页码: 3097-3105
作者:
Yu Lijie
;
Feng Bo
;
Wang Zhijia
;
Gao Lixin
;
Zhang Chun
收藏
  |  
浏览/下载:243/0
  |  
提交时间:2021/11/04
5-phenyl-1,3,4-thiadiazole derivatives
Src homology 2 domain-containing protein tyrosine phosphatase 1 (SHP1)
inhibitors
structure-activity relationships
Metabolic Study of Stable Isotope Labeled Indolinone Derivative in Hepatocyte Cell by UPLC/Q TOF MS
期刊论文
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2021, 卷号: 32, 期号: 6, 页码: 1538-1544
作者:
Yang, Jixia
;
Zhang, Gongzheng
;
Wang, Zhaoyang
;
Meng, Jian
;
Wen, Hongliang
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2021/12/16
indolinone derivatives
alpha-synuclein
[C-3(2), N-15]-isotope labeling, metabolite
UPLC/QTOF
Discovery of 5-Benzylidene-2-phenyl-1,3-dioxane-4,6-diones as Highly Potent and Selective SIRT1 Inhibitors
期刊论文
ACS MEDICINAL CHEMISTRY LETTERS, 2021, 卷号: 12, 期号: 3, 页码: 397-403
作者:
Li, Chunpu
;
Hu, Sha-Sha
;
Yang, Lisheng
;
Wang, Min
;
Long, Jian-Dong
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  |  
浏览/下载:57/0
  |  
提交时间:2021/05/24
SIRT1
inhibitor
structure-activity relationship
interaction
deacetylase
DW14006 as a direct AMPK alpha 1 activator improves pathology of AD model mice by regulating microglial phagocytosis and neuroinflammation
期刊论文
BRAIN BEHAVIOR AND IMMUNITY, 2020, 卷号: 90, 页码: 55-69
作者:
Lv, Jianlu
;
Wang, Wei
;
Zhu, Xialin
;
Xu, Xiaoju
;
Yan, Qiuying
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2020/12/21
Alzheimer'sdisease
Microglia
AMPK alpha 1
DW14006
Phagocytosis
Neuro-inflammation
Synthesis and biological evaluation of heterocyclic bis-aryl amides as novel Src homology 2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 11, 页码: 5
作者:
Satheeshkumar, Rajendran
;
Zhu, Rui
;
Feng, Bo
;
Huang, Chao
;
Gao, Ya
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2020/07/01
Heterocyclic bis-aryl amides
PTP1B
SHP2
Inhibitors
Structure-activity relationships (SAR)
Structural Modifications of the Triazolo-thiadiazole Derivatives as DOT1L Inhibitors and Their Activities
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2020, 卷号: 40, 期号: 5, 页码: 1345-1354
作者:
Xu Xiaoming
;
Guo Siqi
;
Zhang Jing
;
Chen Yantao
;
Kang Yaqing
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2020/12/24
DOT1L inhibitor
ttriazolo-thiadiazole
structural modification
hydrophobic substituent
structure-activity analysis
Pnictogen, chalcogen, and halogen bonds in catalytic systems: theoretical study and detailed comparison
期刊论文
JOURNAL OF MOLECULAR MODELING, 2020, 卷号: 26, 期号: 1, 页码: 12
作者:
Lu, Ling
;
Lu, Yunxiang
;
Zhu, Zhengdan
;
Liu, Honglai
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2020/07/01
sigma-Hole interactions
Catalysis
Comparison
Binding strength
Activity
Pd-Catalyzed intramolecular C-H activation and C-S formation to synthesize pyrazolo[5,1-b]benzothiazoles without an additional oxidant
期刊论文
ORGANIC CHEMISTRY FRONTIERS, 2019, 卷号: 6, 期号: 18, 页码: 3234-3237
作者:
Peng, Yingyuan
;
He, Qian
;
Zhang, Xiaofei
;
Yang, Chunhao
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2020/07/01
Discovery of New Selective Butyrylcholinesterase (BChE) Inhibitors with Anti-A beta Aggregation Activity: Structure-Based Virtual Screening, Hit Optimization and Biological Evaluation
期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 14, 页码: 21
作者:
Jiang, Cheng-Shi
;
Ge, Yong-Xi
;
Cheng, Zhi-Qiang
;
Wang, Yin-Yin
;
Tao, Hong-Rui
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2020/07/01
selective BChE inhibitor
virtual screening
structural optimization
molecular dynamics
anti-A beta aggregation
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