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Exploration of the SAR Connection between Morphinan- and Arylacetamide-Based kappa Opioid Receptor (kappa OR) Agonists Using the Strategy of Bridging 期刊论文
ACS CHEMICAL NEUROSCIENCE, 2021, 卷号: 12, 期号: 6, 页码: 1018-1030
作者:  Liu, Xiao;  Jiang, Shuang;  Kong, Linghui;  Ye, Rongrong;  Xiao, Li
收藏  |  浏览/下载:114/0  |  提交时间:2021/05/24
Design, Synthesis, and Structure-Activity Relationship Exploration of Alkyl/Phenylalkyl Piperidine Analogues as Novel Highly Potent and Selective mu Opioid Receptor Agonists 期刊论文
ACS CHEMICAL NEUROSCIENCE, 2021, 卷号: 12, 期号: 2, 页码: 285-299
作者:  Huang, Huoming;  Li, Xinwei;  Guo, Wei;  Zhu, Chen;  Qian, Yuanyuan
收藏  |  浏览/下载:26/0  |  提交时间:2021/05/24
Design and synthesis of novel desfluoroquinolone-aminopyrimidine hybrids as potent anti-MRSA agents with low hERG activity 期刊论文
BIOORGANIC CHEMISTRY, 2020, 卷号: 103, 页码: 10
作者:  Song, Runzhe;  Wang, Yue;  Wang, Minghui;  Gao, Ruixuan;  Yang, Teng
收藏  |  浏览/下载:25/0  |  提交时间:2020/12/24
Computational study of the substituent effect of halogenated fused-ring heteroaromatics on halogen bonding 期刊论文
JOURNAL OF MOLECULAR MODELING, 2020, 卷号: 26, 期号: 10, 页码: 12
作者:  Zhang, Qihua;  Smalley, Adam;  Zhu, Zhengdan;  Xu, Zhijian;  Peng, Cheng
收藏  |  浏览/下载:52/0  |  提交时间:2020/12/21
Structural Modifications of the Triazolo-thiadiazole Derivatives as DOT1L Inhibitors and Their Activities 期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2020, 卷号: 40, 期号: 5, 页码: 1345-1354
作者:  Xu Xiaoming;  Guo Siqi;  Zhang Jing;  Chen Yantao;  Kang Yaqing
收藏  |  浏览/下载:18/0  |  提交时间:2020/12/24
alpha-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 9, 页码: 4562-4578
作者:  Zhang, Linlin;  Lin, Daizong;  Kusov, Yuri;  Nian, Yong;  Ma, Qingjun
收藏  |  浏览/下载:33/0  |  提交时间:2020/07/01
Synthesis and Structure-Activity Relationship of Palmatine Derivatives as a Novel Class of Antibacterial Agents against Helicobacter pylori 期刊论文
MOLECULES, 2020, 卷号: 25, 期号: 6, 页码: 12
作者:  Fan, Tianyun;  Guo, Xixi;  Zeng, Qingxuan;  Wei, Wei;  You, Xuefu
收藏  |  浏览/下载:23/0  |  提交时间:2020/07/01
2Ch-2N square and hexagon interactions: a combined crystallographic data analysis and computational study 期刊论文
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2019, 卷号: 21, 期号: 38, 页码: 21568-21576
作者:  Lu, Yunxiang;  Li, Wenxia;  Yang, Weiwei;  Zhu, Zhengdan;  Xu, Zhijian
收藏  |  浏览/下载:7/0  |  提交时间:2020/07/01
A comparative study of S center dot center dot center dot pi chalcogen bonds between SF2 or SFH and C-C multiple bonds 期刊论文
JOURNAL OF MOLECULAR STRUCTURE, 2019, 卷号: 1188, 页码: 62-68
作者:  Su, He;  Wu, Han;  Wang, Hui;  Wang, Hongyan;  Ni, Yuxiang
收藏  |  浏览/下载:8/0  |  提交时间:2020/07/01
Pharmacokinetics-Driven Optimization of 4(3H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 10, 页码: 4979-4990
作者:  Wang, Zhen;  Jiang, Xiangrui;  Zhang, Xianglei;  Tian, Guanghui;  Yang, Rulei
收藏  |  浏览/下载:40/0  |  提交时间:2020/07/01


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