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科研机构
上海药物研究所 [18]
内容类型
期刊论文 [18]
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2021 [1]
2019 [2]
2018 [3]
2017 [1]
2016 [2]
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Psychiatry [1]
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内容类型:期刊论文
专题:上海药物研究所
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Structural basis of ketamine action on human NMDA receptors
期刊论文
NATURE, 2021, 卷号: 596, 期号: 7871, 页码: 301-+
作者:
Zhang, Youyi
;
Ye, Fei
;
Zhang, Tongtong
;
Lv, Shiyun
;
Zhou, Liping
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2021/11/04
Synthesis and Biological Evaluation of Five-Atom-Linker-Based Arylpiperazine Derivatives with an Atypical Antipsychotic Profile
期刊论文
CHEMMEDCHEM, 2019, 页码: 11
作者:
Wu, Chunhui
;
Wang, Yu
;
Yang, Feipu
;
Shi, Wenqiang
;
Wang, Zhen
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2020/07/01
D-2
5-HT1A
5-HT2A
serotonin
SERT
PCP-induced hyperactivity
Identifying the active components of Baihe-Zhimu decoction that ameliorate depressive disease by an effective integrated strategy: a systemic pharmacokinetics study combined with classical depression model tests
期刊论文
CHINESE MEDICINE, 2019, 卷号: 14, 期号: 1, 页码: 11
作者:
Zhong, Ming
;
Tian, Xiaoting
;
Chen, Shuoji
;
Chen, Mingcang
;
Guo, Ziqiong
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2020/07/01
Baihe-Zhimu decoction
Antidepressant
Timosaponin BII
Timosaponin BIII
Drug discovery
Positive Allosteric Modulation of AMPAR by PF-4778574 Produced Rapid Onset Antidepressant Actions in Mice
期刊论文
Cerebral cortex (New York, N.Y. : 1991), 2018
作者:
Shen, Mengxin
;
Lv, Dan
;
Li, Shuting
;
Zhang, Yanhua
;
Wang, Zhen
收藏
  |  
浏览/下载:107/0
  |  
提交时间:2019/01/08
7 beta-Methyl substituent is a structural locus associated with activity cliff for nepenthone analogues
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 14, 页码: 4254-4263
作者:
Sun, Hui-jiao
;
Wang, Yu-hua
;
Yuan, Cong-min
;
Kong, Ling-hui
;
Xu, Xue-jun
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  |  
浏览/下载:85/0
  |  
提交时间:2019/01/08
7 beta-Methyl-nepenthone analogues
KOR ligands
Concept of hybridization
Opioid receptor binding and functional activities
Vesicular glutamate transporter 1 (VGLUT1)-mediated glutamate release and membrane GluA1 activation is involved in the rapid antidepressant-like effects of scopolamine in mice
期刊论文
NEUROPHARMACOLOGY, 2018, 卷号: 131, 页码: 209-222
作者:
Yu, Hanjie
;
Li, Mengmeng
;
Zhou, Dongsheng
;
Lv, Dan
;
Liao, Qi
收藏
  |  
浏览/下载:80/0
  |  
提交时间:2019/01/08
Scopolamine
alpha-Amino-3-1-lydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)
Vesicular glutamate transporter 1 (VGLUT1)
Brain-derived neurotrophic factor (BDNF)
VGF (non-acronymic)
Bicaudal C homolog 1 gene (BICC1)
Activation of D1R/PKA/mTOR signaling cascade in medial prefrontal cortex underlying the antidepressant effects of l-SPD
期刊论文
SCIENTIFIC REPORTS, 2017, 卷号: 7
作者:
Zhang, Bing
;
Guo, Fei
;
Ma, Yuqin
;
Song, Yingcai
;
Lin, Rong
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  |  
浏览/下载:26/0
  |  
提交时间:2019/01/08
The rapid antidepressant and anxiolytic-like effects of YY-21 involve enhancement of excitatory synaptic transmission via activation of mTOR signaling in the mPFC
期刊论文
EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2016, 卷号: 26, 期号: 7, 页码: 1087-1098
作者:
Guo, Fei
;
Zhang, Bing
;
Fu, Zhiwen
;
Ma, Yuqin
;
Gao, Yu
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/01/08
YY-21
mTOR
Synaptic transmission
Synaptic proteins
Computational insights into different inhibition modes of the kappa-opioid receptor with antagonists LY2456302 and JDTic
期刊论文
RSC ADVANCES, 2016, 卷号: 6, 期号: 17, 页码: 13626-13635
作者:
Cheng, Jianxin
;
Li, Weihua
;
Liu, Guixia
;
Zhu, Weiliang
;
Tang, Yun
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/01/08
TREK1 channel blockade induces an antidepressant-like response synergizing with 5-HT1A receptor signaling
期刊论文
EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2015, 卷号: 25, 期号: 12, 页码: 2426-2436
作者:
Ye, Dongqing
;
Li, Yang
;
Zhang, Xiangrong
;
Guo, Fei
;
Geng, Leiyu
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/01/08
TWIK-related mechano-gated K+ channel (TREK1)
Antidepressant
SID1900
5-HT1A receptor
Chronic unpredictable mild stress (CUMS)
Brain derived neurotrophic factor (BDNF)
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