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科研机构
上海药物研究所 [7]
合肥物质科学研究院 [4]
过程工程研究所 [1]
兰州化学物理研究所 [1]
内容类型
期刊论文 [13]
发表日期
2021 [13]
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CD71-Specific Aptamer Conjugated with Monomethyl Auristatin E for the Treatment of Uveal Melanoma
期刊论文
ACS APPLIED MATERIALS & INTERFACES, 2021
作者:
Zhang, Hui
;
Jin, Cheng
;
Zhang, Lin
;
Peng, Bo
;
Zhang, Yibin
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2022/02/14
uveal melanoma
CD71
aptamer-drug conjugate
targeted drug delivery
tumor-targeted therapy
DHOK Exerts Anti-Cancer Effect Through Autophagy Inhibition in Colorectal Cancer
期刊论文
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 卷号: 9
作者:
Shu, Yuhan
;
Sun, Xin
;
Ye, Guiqin
;
Xu, Mengting
;
Wu, Zhipan
收藏
  |  
浏览/下载:156/0
  |  
提交时间:2022/02/14
DHOK
transcriptome sequencing
autophagy
colorectal cancer
mTOR pathway
Discovery and Development of a Potent, Selective, and Orally Bioavailable CHK1 Inhibitor Candidate: 5-((4-((3-Amino-3-methylbutyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)picolinonitrile
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 20, 页码: 15069-15090
作者:
Jin, Tingting
;
Xu, Lei
;
Wang, Peipei
;
Hu, Xiaobei
;
Zhang, Runyuan
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2022/01/04
Super-enhancer-associated TMEM44-AS1 aggravated glioma progression by forming a positive feedback loop with Myc
期刊论文
Journal of Experimental & Clinical Cancer Research, 2021, 卷号: 40
作者:
Bian,Erbao
;
Chen,Xueran
;
Cheng,Li
;
Cheng,Meng
;
Chen,Zhigang
收藏
  |  
浏览/下载:302/0
  |  
提交时间:2021/11/15
Glioma
lncRNA
TMEM44-AS1
Super-enhancer
Myc
Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 19, 页码: 14647-14663
作者:
Han, Xu
;
Song, Ning
;
Saidahmatov, Abdusaid
;
Wang, Peipei
;
Wang, Yong
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  |  
浏览/下载:17/0
  |  
提交时间:2021/12/16
Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Zhou, Yu-bo
;
Zhang, Yang-ming
;
Huang, Hong-hui
;
Shen, Li-jing
;
Han, Xiao-feng
收藏
  |  
浏览/下载:97/0
  |  
提交时间:2021/11/04
multiple myeloma
HDAC inhibitor
bisthianostat
pharmacodynamics
pharmacokinetics
phase 1a clinical trial
antitumor drug
A novel phosphoramide compound, DCZ0805, shows potent anti-myeloma activity via the NF-κB pathway
期刊论文
Cancer Cell International, 2021, 卷号: 21, 期号: 1
作者:
Gao,Xuejie
;
Li,Bo
;
Ye,Anqi
;
Wang,Houcai
;
Xie,Yongsheng
收藏
  |  
浏览/下载:98/0
  |  
提交时间:2021/06/11
Multiple myeloma
Anti-tumor activity
NF-κB
A novel phosphoramide compound, DCZ0805, shows potent anti-myeloma activity via the NF-kappa B pathway
期刊论文
CANCER CELL INTERNATIONAL, 2021, 卷号: 21, 期号: 1, 页码: 10
作者:
Gao, Xuejie
;
Li, Bo
;
Ye, Anqi
;
Wang, Houcai
;
Xie, Yongsheng
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/08/17
Multiple myeloma
Anti-tumor activity
NF-kappa B
Combination of GC-MS based metabolomics analysis with mouse xenograft models reveals a panel of dysregulated circulating metabolites and potential therapeutic targets for colorectal cancer
期刊论文
TRANSLATIONAL CANCER RESEARCH, 2021, 卷号: 10
作者:
Ni, Juan
;
Chen, Yang
;
Li, Ningning
;
Sun, Diandian
;
Ju, Haixing
收藏
  |  
浏览/下载:88/0
  |  
提交时间:2021/06/15
Gas chromatography-mass spectrometry (GC-MS)
metabolomics
colorectal cancer (CRC)
amino acid transporter
Discovery of MTR-106 as a highly potent G-quadruplex stabilizer for treating BRCA-deficient cancers
期刊论文
INVESTIGATIONAL NEW DRUGS, 2021, 页码: 9
作者:
Li, Meng-Zhu
;
Meng, Tao
;
Song, Shan-Shan
;
Bao, Xu-Bin
;
Ma, Lan-Ping
收藏
  |  
浏览/下载:69/0
  |  
提交时间:2021/05/24
G-quadruplex stabilizer
MTR-106
BRCA-deficiency
PARP inhibitor
DNA damage
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