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科研机构
上海药物研究所 [9]
兰州理工大学 [2]
合肥物质科学研究院 [2]
新疆理化技术研究所 [1]
内容类型
期刊论文 [14]
发表日期
2021 [14]
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LS-106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo
期刊论文
CANCER SCIENCE, 2021, 页码: 12
作者:
Liu, Yingqiang
;
Lai, Mengzhen
;
Li, Shan
;
Wang, Yanan
;
Feng, Fang
收藏
  |  
浏览/下载:63/0
  |  
提交时间:2022/01/18
C797S
epidermal growth factor receptor
fourth-generation EGFR TKI
non-small cell lung cancer
osimertinib resistance
Discovery of a novel DDRs kinase inhibitor XBLJ-13 for the treatment of idiopathic pulmonary fibrosis
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Dong, Ying
;
Tang, Bi-xi
;
Wang, Qi
;
Zhou, Li-wei
;
Li, Cong
收藏
  |  
浏览/下载:80/0
  |  
提交时间:2022/01/04
idiopathic pulmonary fibrosis
DDRs
kinase inhibitor
indazole derivatives
XBLJ-13
nintedanib
bleomycin-induced pulmonary fibrosismouse model
Identification of phosphodiesterase-4 as the therapeutic target of arctigenin in alleviating psoriatic skin inflammation
期刊论文
JOURNAL OF ADVANCED RESEARCH, 2021, 卷号: 33, 页码: 241-251
作者:
Li, Heng
;
Zhang, Xianglei
;
Xiang, Caigui
;
Feng, Chunlan
;
Fan, Chen
收藏
  |  
浏览/下载:89/0
  |  
提交时间:2021/11/04
PDE4
Arctigenin
Psoriasis
Inflammation
The Novel RET Inhibitor SYHA1815 Inhibits RET-Driven Cancers and Overcomes Gatekeeper Mutations by Inducing G1 Cell-Cycle Arrest through c-Myc Downregulation
期刊论文
MOLECULAR CANCER THERAPEUTICS, 2021, 卷号: 20, 期号: 11, 页码: 2198-2206
作者:
Jiang, Yuchen
;
Peng, Xia
;
Ji, Yinchun
;
Dai, Yang
;
Fang, Yanfen
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2021/12/16
FPS-ZM1 inhibits LPS-induced microglial inflammation by suppressing JAK/STAT signaling pathway
期刊论文
INTERNATIONAL IMMUNOPHARMACOLOGY, 2021, 卷号: 100, 页码: 12
作者:
Wang, Lan
;
Zhao, Danfeng
;
Wang, Huan
;
Wang, Lele
;
Liu, Xiaohui
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  |  
浏览/下载:62/0
  |  
提交时间:2021/12/01
Inflammation
Microglia
LPS
RNA-seq
JAK
STAT signaling pathway
Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 19, 页码: 14647-14663
作者:
Han, Xu
;
Song, Ning
;
Saidahmatov, Abdusaid
;
Wang, Peipei
;
Wang, Yong
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2021/12/16
Wortmannine H, a phenylpentenol isolated from an endophytic fungus, Talaromyces wortmannii LGT-4
期刊论文
NATURAL PRODUCT RESEARCH, 2021, 卷号: 35, 期号: 19, 页码: 3204-3209
作者:
Li, Xiao-Fei
;
Yang, Zhong-Duo
;
Yang, Xing
;
Yang, Li-Jun
;
Yao, Xiao-Jun
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2021/10/14
Wortmannine
endophytic fungus
Talaromyces wortmannii
Tripterygium wilfordii
Discovery of a potent, selective, and covalent ZAP-70 kinase inhibitor
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 219, 页码: 12
作者:
Rao, Danni
;
Li, Heng
;
Ren, Xuelian
;
Sun, Yaoliang
;
Wen, Cuiyun
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2021/08/17
Zeta-chain associated protein kinase 70 kDa (ZAP-70)
Covalent inhibitor
T cell
Autoimmune diseases
Stephtetrandrine A-D, bisbenzylisoquinoline alkaloids from Stephania tetrandra
期刊论文
NATURAL PRODUCT RESEARCH, 2021
作者:
Yang, Li-Jun
;
Yang, Zhong-Duo
;
Li, Zhi-Jie
;
Yang, Shu-Hong
;
Shu, Zong-Mei
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2021/10/14
Stephania tetrandra
Menispermaceae
structure elucidation
bisbenzylisoquinoline alkaloids
enzyme inhibition
Stephtetrandrine
Discovery of a highly potent kinase inhibitor capable of overcoming multiple imatinib-resistant ABL mutants for chronic myeloid leukemia (CML)
期刊论文
EUROPEAN JOURNAL OF PHARMACOLOGY, 2021, 卷号: 897
作者:
Lu, Tingting
;
Cao, Jiangyan
;
Zou, Fengming
;
Li, Xixiang
;
Wang, Aoli
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2021/04/26
BCR-ABL
ABL mutants
Chronic myeloid leukemia
Kinase inhibitor
Imatinib resistance
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