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科研机构
上海药物研究所 [19]
过程工程研究所 [3]
合肥物质科学研究院 [3]
心理研究所 [2]
西双版纳热带植物园 [1]
新疆理化技术研究所 [1]
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期刊论文 [32]
发表日期
2021 [32]
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Pharmacolo... [1]
Toxicology [1]
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A camptothecin-based, albumin-binding prodrug enhances efficacy and safety in vivo
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 226, 页码: 11
作者:
Cheng, Zhiyang
;
Huang, Ying
;
Shen, Qianqian
;
Zhao, Yangrong
;
Wang, Lei
收藏
  |  
浏览/下载:86/0
  |  
提交时间:2021/11/04
Cancer
beta-glucuronidase
Bioconjugation
Albumin
Camptothecin
Site-specific protein modification by 3-n-butylphthalide in primary hepatocytes: Covalent protein adducts diminished by glutathione and N-acetylcysteine
期刊论文
LIFE SCIENCES, 2021, 卷号: 287, 页码: 14
作者:
Xue, Yaru
;
Ren, Xuelian
;
Zhu, Zhengdan
;
Lei, Peng
;
Liu, Mengling
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  |  
浏览/下载:39/0
  |  
提交时间:2022/01/18
3-n-butylphthalide
Hepatotoxicity
Oxidative stresses
Covalent protein modification
Drug-drug interaction
Discovery of a novel DDRs kinase inhibitor XBLJ-13 for the treatment of idiopathic pulmonary fibrosis
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Dong, Ying
;
Tang, Bi-xi
;
Wang, Qi
;
Zhou, Li-wei
;
Li, Cong
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  |  
浏览/下载:73/0
  |  
提交时间:2022/01/04
idiopathic pulmonary fibrosis
DDRs
kinase inhibitor
indazole derivatives
XBLJ-13
nintedanib
bleomycin-induced pulmonary fibrosismouse model
Combating liver cancer through GO-targeted biomaterials
期刊论文
BIOMEDICAL MATERIALS, 2021, 卷号: 16, 期号: 6, 页码: 14
作者:
Huang, Xing
;
Zhang, Jiaxin
;
Song, Yijie
;
Zhang, Tong
;
Wang, Bing
收藏
  |  
浏览/下载:62/0
  |  
提交时间:2021/11/04
graphene oxide
hydroxycamptothecin
anti-cancer
drug delivery system
targeting
Antifungal azoles and azole resistance in the environment: current status and future perspectives-a review
期刊论文
REVIEWS IN ENVIRONMENTAL SCIENCE AND BIO-TECHNOLOGY, 2021, 页码: 31
作者:
Assress, Hailemariam Abrha
;
Selvarajan, Ramganesh
;
Nyoni, Hlengilizwe
;
Mamba, Bhekie B.
;
Msagati, Titus A. M.
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  |  
浏览/下载:31/0
  |  
提交时间:2021/11/16
Occurrence
Azole antifungal drugs
Azole resistance
Future perspectives
Fungi
Environment
Quantitative Electrophysiological Evaluation of the Analgesic Efficacy of Two Lappaconitine Derivatives: A Window into Antinociceptive Drug Mechanisms
期刊论文
NEUROSCIENCE BULLETIN, 2021, 页码: 15
作者:
Teng, Guixiang
;
Zhang, Fengrui
;
Li, Zhenjiang
;
Zhang, Chun
;
Zhang, Libo
收藏
  |  
浏览/下载:60/0
  |  
提交时间:2021/10/29
Electrocorticogram
Analgesic effect
Lappaconitine derivatives
Antinociceptive mechanisms
Laser-evoked potentials
Synthesis and Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitory Activity Evaluation of Novel N-Acylhydrazone Derivatives Containing Carbazole and Aromatic Ring/Aromatic Fused Heterocycle
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 41, 期号: 9, 页码: 3593-3607
作者:
Li Yingjun
;
Lin Ledi
;
Liu Jihong
;
Gao Lixin
;
Sheng Li
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2021/12/01
PTP1B inhibitor
carbazole
N-actylhydrazone
synthesis
molecular docking
ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker
期刊论文
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 卷号: 6, 期号: 1, 页码: 9
作者:
Chen, Yuning
;
Zhang, Ya-Nan
;
Yan, Renhong
;
Wang, Guifeng
;
Zhang, Yuanyuan
收藏
  |  
浏览/下载:67/0
  |  
提交时间:2021/11/04
Metabolic map of the antiviral drug podophyllotoxin provides insights into hepatotoxicity
期刊论文
XENOBIOTICA, 2021, 页码: 13
作者:
Sun, Dongxue
;
Gao, Xiaoxia
;
Wang, Qiao
;
Krausz, Kristopher W.
;
Fang, Zhongze
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2021/11/04
CYP
podophyllotoxin metabolism
liver microsomes
recombinant drug-metabolizing enzymes
hepatic and intestinal toxicity
A nanoselenium-coating biomimetic cytomembrane nanoplatform for mitochondrial targeted chemotherapy- and chemodynamic therapy through manganese and doxorubicin codelivery
期刊论文
JOURNAL OF NANOBIOTECHNOLOGY, 2021, 卷号: 19
作者:
Xiao, Jianmin
;
Yan, Miao
;
Zhou, Ke
;
Chen, Hui
;
Xu, Zhaowei
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2021/08/30
Cell membrane
Reactive oxygen species
Superoxide dismutase-1
Glutathione peroxidase 4
Dual-mode therapeutic pathways
Drug delivery system
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