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科研机构
上海药物研究所 [7]
大连理工大学 [1]
上海健康医学院 [1]
沈阳自动化研究所 [1]
内容类型
期刊论文 [10]
发表日期
2020 [10]
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Anti-PD-L1 mediating tumor-targeted codelivery of liposomal irinotecan/JQ1 for chemo-immunotherapy
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 8
作者:
He, Zhi-di
;
Zhang, Meng
;
Wang, Yong-hui
;
He, Yang
;
Wang, Hai-rui
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2021/05/24
tumor-targeted delivery
immunogenic cell death
PD-1
PD-L1 blockade
tumor immune microenvironment
irinotecan
JQ1
immune checkpoint
Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion
期刊论文
ADVANCED SCIENCE, 2020, 页码: 13
作者:
Sun, Zhongya
;
Zhang, Hao
;
Zhang, Yuanyuan
;
Liao, Liping
;
Zhou, Wen
收藏
  |  
浏览/下载:107/0
  |  
提交时间:2020/07/01
anti-metastasis activities
crystal structures
inhibitors
novel pockets
rho family proteins
Design and synthesis of selective degraders of EGFR(L858R/T790M) mutant
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 192, 页码: 14
作者:
Zhang, Xin
;
Xu, Fang
;
Tong, Linjiang
;
Zhang, Tao
;
Xie, Hua
收藏
  |  
浏览/下载:83/0
  |  
提交时间:2020/07/01
Epidermal growth factor receptor (EGFR)
Resistance
Proteolysis targeting chimera (PROTAC)
Protein degradation
Discovery of novel glyceraldehyde-3-phosphate dehydrogenase inhibitor via docking-based virtual screening
期刊论文
BIOORGANIC CHEMISTRY, 2020, 卷号: 96, 页码: 10
作者:
Li, Ting
;
Tan, Xiaoqin
;
Yang, Ruirui
;
Miao, Ying
;
Zhang, Min
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/07/01
Glyceraldehyde-3-phosphate dehydrogenase
Inhibitor
Virtual screening
Glycolysis
Cancer
Discovery of novel CBP bromodomain inhibitors through TR-FRET-based high-throughput screening
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 卷号: 41, 期号: 2, 页码: 286-292
作者:
Zhang, Feng-cai
;
Sun, Zhong-ya
;
Liao, Li-ping
;
Zuo, Yu
;
Zhang, Dan
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2020/07/01
CBP bromodomain
small-molecule inhibitor
high-throughput screening
TR-FRET
molecular modeling
human leukemia MV4-11 cells
A microfluidic platform culturing two cell lines paralleled under in-vivo like fluidic microenvironment for testing the tumor targeting of nanoparticles
期刊论文
Talanta, 2020, 卷号: 208
作者:
Wei, Juan
;
Cheng, Lichun
;
Li, Jingmin
;
Liu, Yuanchang
;
Yin, Shuqing
收藏
  |  
浏览/下载:56/0
  |  
提交时间:2019/12/02
MicroRNA-326 decreases tau phosphorylation and neuron apoptosis through inhibition of the JNK signaling pathway by targeting VAV1 in Alzheimer's disease
期刊论文
JOURNAL OF CELLULAR PHYSIOLOGY, 2020, 卷号: 235, 期号: 1
作者:
He, Bin
;
Chen, Wei
;
Zeng, Jingsong
;
Tong, Wusong
;
Zheng, Ping
收藏
  |  
浏览/下载:105/0
  |  
提交时间:2019/12/06
Alzheimer's disease
JNK signaling pathway
microRNA-326
neuron apoptosis
phosphorylated Tau
VAV1
discoveryofnovelcbpbromodomaininhibitorsthroughtrfretbasedhighthroughputscreening
期刊论文
actapharmacologicasinica, 2020, 卷号: 41, 期号: 2, 页码: 285
作者:
Zhang Fengcai
;
Sun Zhongya
;
Liao Liping
;
Zuo Yu
;
Zhang Dan
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2020/07/01
CBP bromodomain
small-molecule inhibitor
high-throughput screening
TR-FRET
molecular modeling
human leukemia MV4-11 cells
Stepwise targeting and responsive lipid-coated nanoparticles for enhanced tumor cell sensitivity and hepatocellular carcinoma therapy
期刊论文
THERANOSTICS, 2020, 卷号: 10, 期号: 8, 页码: 3722-3736
作者:
Li, Ying
;
Miao, Yunqiu
;
Chen, Mingshu
;
Chen, Xi
;
Li, Feifei
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2020/07/01
drug delivery
pH sensitive
charge conversion
tumor targeting
hepatocellular carcinoma
MR-Forest: A Deep Decision Framework for False Positive Reduction in Pulmonary Nodule Detection
期刊论文
IEEE Journal of Biomedical and Health Informatics, 2020, 卷号: 24, 期号: 6, 页码: 1652-1663
作者:
Zhu, Hongbo
;
Zhao, Hai
;
Song CH(宋纯贺)
;
Bian, Zijian
;
Bi, Yuanguo
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/11/14
False positive reduction
Spherical surface feature
Deep decision
ORFs
Computer tomography
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