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科研机构
上海药物研究所 [2]
湖南中医药大学 [1]
福州大学 [1]
中国医学科学院 北京... [1]
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期刊论文 [5]
发表日期
2019 [5]
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Research Progress in Tumor Therapy Targeting Plasminogen Activator Inhibitor-1
期刊论文
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2019, 卷号: 46, 期号: 7, 页码: 663-672
作者:
Liu Ji-Hao
;
Tang Shu-Zhi
;
Hu Li-Hong
;
Huang Ming-Dong
;
Chen Zhuo
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2020/07/01
tumor therapy
plasminogen activator inhibitor-1
tumor microenvironment
tPA Point Mutation at Autolysis Loop Enhances Resistance to PAI-1 Inhibition and Catalytic Activity
期刊论文
THROMBOSIS AND HAEMOSTASIS, 2019, 卷号: 119, 页码: 77-86
作者:
Peng, Shuangzhou
;
Xue, Guangpu
;
Chen, Shanli
;
Chen, Zhuo
;
Yuan, Cai
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/11/21
thrombolysis
stroke
tissue-type plasminogen activator
bioengineering
PAI-1 resistance
IMM-H004 therapy for permanent focal ischemic cerebral injury via CKLF1/CCR4-mediated NLRP3 inflammasome activation
期刊论文
2019, 卷号: 212, 页码: 36-53
作者:
Ai Q D
;
Chen Chen
;
Chu Shifeng
;
Zhang Zhao
;
Luo Yun
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2020/01/03
ASC = apoptosis-associated speck-like protein containing a caspase activation recruitment domain
BCA = bicinchoninic acid
BSA = bovine serum albumin
CCA = common carotid artery
CCR4 = C-C chemokine receptor type 4
CKLF1 = chemokine-like factor 1
CO-IP = coimmunoprecipitation
ECA = external carotid artery
ELISA = enzyme-linked immunosorbent assay
FDA = Food and Drug Administration
I/R = ischemic/reperfusion
ICA = internal carotid artery
IL-18 = interleukin 18
IL-1β = interleukin 1β
LDH = lactate dehydrogenase
NLRP3 = NOD-like receptor protein 3
PBS = phosphate-buffered saline
SD = standard deviation
TNF-α = tumor necrosis factor α
TTC = 2
3
5-triphenyltetrazolium-chloride
WT = wild-type
pMCAO = permanent middle cerebral artery occlusion
pro-Caspase-1 = precursor Caspase-1
qPCR = quantitative real-time PCR
tMCAO = transient middle cerebral artery occlusion
tPA = tissue plasminogen activator
NK cells in cerebral ischemia
期刊论文
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, 卷号: 109, 页码: 547-554
作者:
Chen, Chen
;
Ai, Qi-Di
;
Chu, Shi-Feng
;
Zhang, Zhao
;
Chen, Nai-Hong*
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  |  
浏览/下载:36/0
  |  
提交时间:2019/12/27
tPA
tissue plasminogen activator
IS
ischemic stroke
BBB
blood-brain barrier
IFN-γ
interferon-γ
pMCAO
permanent middle cerebral artery occlusion
tMCAO
transient middle cerebral artery occlusion
CX3CR1
CX3CL1 receptor
CNS
central nervous system
AchE
acetylcholine esterase
CFSE
arboxyfluorescein diacetate succinimidyl ester
HI
hypoxic ischemia
MCAO IP-10
interferon-inducible protein-10
IL
interleukin
GFAP
glial fibrillary acidic protein
tg
transgenic
WT
wild-type
APC
antigen presenting cell
SAI
stroke-associated infection
STAT3
signal transducer and activator of transcription-3
HPA
hypothalamic-pituitary-adrenal
cSVD
cerebral small vessel disease
SHR
spontaneously hypertensive rat
CSF
cerebrospinal fluid
aSAH
aneurysmal subarachnoid hemorrhage
DCI
delayed cerebral ischemia
MRI
magnetic resonance imaging
CT
computed tomography
EVs
extracellular vesicles
MSC
mesenchymal stem cell
MNCs
bone marrow-derived mononuclear cells
CpG-ODN
cytosine-guanine oligodideoxynucleotide
TLR9
toll-like receptor 9
TNF
tumor necrosis factor
NK cells
Cerebral ischemia
Inflammation
Immunodpression
Infection
靶向纤溶酶原激活物抑制剂1的肿瘤治疗研究进展
期刊论文
生物化学与生物物理进展, 2019, 卷号: 46, 期号: 7, 页码: 663
作者:
刘吉昊
;
唐述志
;
胡立宏
;
黄明东
;
陈卓
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2020/07/01
肿瘤治疗
纤溶酶原激活物抑制剂1
肿瘤微环境
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