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上海药物研究所 [18]
大连化学物理研究所 [4]
生态环境研究中心 [4]
植物研究所 [3]
湖南大学 [2]
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期刊论文 [42]
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2019 [42]
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Targeting epigenetic machinery: Emerging novel allosteric inhibitors
期刊论文
PHARMACOLOGY & THERAPEUTICS, 2019, 卷号: 204, 页码: 24
作者:
Ye, Fei
;
Huang, Jing
;
Wang, Hongbo
;
Luo, Cheng
;
Zhao, Kehao
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2020/07/01
Epigenetics
PRC2
MLL complex
SWI/SNF
DNMT1
allosteric inhibitors
C10ORF12 modulates PRC2 histone methyltransferase activity and H3K27me3 levels
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 11, 页码: 1457-1465
作者:
Shi, Yi
;
Ma, Hong-lei
;
Zhuang, You-wen
;
Wang, Xiao-xi
;
Jiang, Yi
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2020/07/01
PRC2
C10ORF12
H3K27me3
histone methyltransferase
epigenetic regulation
histone modification
Dynamic modifications of biomacromolecules: mechanism and chemical interventions
期刊论文
SCIENCE CHINA-LIFE SCIENCES, 2019, 卷号: 62, 期号: 11, 页码: 1459-1471
作者:
Wang, Chu
;
Zou, Peng
;
Yang, Caiguang
;
Liu, Lei
;
Cheng, Liang
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  |  
浏览/下载:15/0
  |  
提交时间:2020/07/01
chemical biology
biomacromolecule
dynamic modification
modification analysis
chemical intervention
Long noncoding RNA LINC00336 inhibits ferroptosis in lung cancer by functioning as a competing endogenous RNA
期刊论文
CELL DEATH AND DIFFERENTIATION, 2019, 卷号: 26, 期号: 11, 页码: 2329-2343
作者:
Wang, Min
;
Mao, Chao
;
Ouyang, Lianlian
;
Liu, Yating
;
Lai, Weiwei
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  |  
浏览/下载:36/0
  |  
提交时间:2020/07/01
SET8 prevents excessive DNA methylation by methylation-mediated degradation of UHRF1 and DNMT1
期刊论文
NUCLEIC ACIDS RESEARCH, 2019, 卷号: 47, 期号: 17, 页码: 9053-9068
作者:
Zhang, Huifang
;
Gao, Qinqin
;
Tan, Shuo
;
You, Jia
;
Lyu, Cong
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  |  
浏览/下载:15/0
  |  
提交时间:2020/09/10
Reductive methylation labeling, from quantitative to structural proteomics
期刊论文
TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2019, 卷号: 118, 页码: 771-778
作者:
Liu, Zheyi
;
Zhou, Ye
;
Liu, Jing
;
Chen, Jin
;
Heck, Albert J. R.
收藏
  |  
浏览/下载:104/0
  |  
提交时间:2019/12/02
Reductive methylation
Stable isotope dimethyl labeling
Mass spectrometry
Quantitative proteomics
N-termini profiling
Structural proteomics
Lysine reactivity profiling
A new chromatographic approach to analyze methylproteome with enhanced lysine methylation identification performance
期刊论文
ANALYTICA CHIMICA ACTA, 2019, 卷号: 1068, 页码: 111-119
作者:
Wang, Qi
;
Liu, Zhen
;
Wang, Keyun
;
Wang, Yan
;
Ye, Mingliang
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  |  
浏览/下载:268/0
  |  
提交时间:2019/06/20
Methylproteome
Strong cation exchange
Immobilized metal ion affinity chromatography
High-pH reversed-phase chromatography
Lysine methylation identification
Structural characterization of a galactan from Dioscorea opposita Thunb. and its bioactivity on selected Bacteroides strains from human gut microbiota
期刊论文
CARBOHYDRATE POLYMERS, 2019, 卷号: 218, 页码: 299-306
作者:
Zhang, Chun-Qian
;
Chen, Xia
;
Ding, Kan
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  |  
浏览/下载:14/0
  |  
提交时间:2020/07/01
Dioscoreaopposita Thunb.
Polysaccharide
Galactan
Human gut microbiota
Short-chain fatty acids
Inhibition of G9a by a small molecule inhibitor, UNC0642, induces apoptosis of human bladder cancer cells
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 8, 页码: 1076-1084
作者:
Cao, Yue-peng
;
Sun, Jing-ya
;
Li, Mei-qian
;
Dong, Yu
;
Zhang, Yuan-heng
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/07/01
human urinary bladder cancer
G9a
UNC0642
apoptosis
Rational Design, synthesis and biological evaluation of novel triazole derivatives as potent and selective PRMT5 inhibitors with antitumor activity
期刊论文
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2019, 卷号: 33, 期号: 8, 页码: 775-785
作者:
Zhu, Kongkai
;
Shao, Jingwei
;
Tao, Hongrui
;
Yan, Xue
;
Luo, Cheng
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2020/07/01
PRMT5 inhibitor
Anti-proliferative
Cellular target validation
Design and synthesis
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