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上海药物研究所 [63]
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期刊论文 [243]
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2019 [249]
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Deciphering molecular mechanism behind conformational change of the Sao Paolo metallo-beta-lactamase 1 by using enhanced sampling
期刊论文
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2019, 页码: 12
作者:
Chen, Jianzhong
;
Wang, Jinan
;
Pang, Laixue
;
Wang, Wei
;
Zhao, Juan
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2020/07/01
Sao paolo metallo-beta-lactamase-1
REMD simulations
normal mode analysis
principal component analysis
drug resistance of antibiotics
Pao Pereira Extract Attenuates Testosterone-Induced Benign Prostatic Hyperplasia in Rats by inhibiting 5 alpha-Reductase
期刊论文
SCIENTIFIC REPORTS, 2019, 卷号: 9, 页码: 10
作者:
Liu, Jiakuan
;
Fang, Tian
;
Li, Meiqian
;
Song, Yuting
;
Li, Junzun
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2020/07/01
Imaging Tumorous Methylglyoxal by an Activatable Near-Infrared Fluorescent Probe for Monitoring Glyoxalase 1 Activity
期刊论文
ANALYTICAL CHEMISTRY, 2019, 卷号: 91, 期号: 24, 页码: 15577-15584
作者:
Ding, Chunyong
;
Wang, Fengyang
;
Dang, Yijing
;
Xu, Zhiai
;
Li, Lingling
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/07/01
DZ2002 ameliorates fibrosis, inflammation, and vasculopathy in experimental systemic sclerosis models
期刊论文
ARTHRITIS RESEARCH & THERAPY, 2019, 卷号: 21, 期号: 1, 页码: 15
作者:
Zhang, Zongwang
;
Wu, Yanwei
;
Wu, Bing
;
Qi, Qing
;
Li, Heng
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2020/07/01
Systemic sclerosis
SAHH inhibitor
Fibrosis
Inflammation
Vasculopathy
TGF-beta
alpha-Mangostin remodels visceral adipose tissue inflammation to ameliorate age-related metabolic disorders in mice
期刊论文
AGING-US, 2019, 卷号: 11, 期号: 23, 页码: 11084-11110
作者:
Li, Dan
;
Liu, Qianyu
;
Lu, Xiuqiang
;
Li, Zhengqiu
;
Wang, Chunming
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  |  
浏览/下载:51/0
  |  
提交时间:2020/07/01
alpha-mangostin
aging
adiposity
adipose tissue inflammation
macrophage
Discovery of Novel Androgen Receptor Ligands by Structure-based Virtual Screening and Bioassays
期刊论文
GENOMICS PROTEOMICS & BIOINFORMATICS, 2019, 卷号: 16, 期号: 6, 页码: 416-427
作者:
Hou, Tingjun
;
Li, Dan
;
Chang, Shan
;
Xu, Lei
;
Sun, Huiyong
收藏
  |  
浏览/下载:269/0
  |  
提交时间:2019/06/24
Androgen receptor
AR ligand
Virtual screening
AR agonist
AR antagonist
Caffeic acid reduces A53T alpha-synuclein by activating JNK/Bcl-2-mediated autophagy in vitro and improves behaviour and protects dopaminergic neurons in a mouse model of Parkinson's disease
期刊论文
PHARMACOLOGICAL RESEARCH, 2019, 卷号: 150, 页码: 14
作者:
Zhang, Yu
;
Wu, Qimei
;
Zhang, Lei
;
Wang, Qing
;
Yang, Zexian
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2020/07/01
Caffeic acid
A53T
Parkinson's disease
Autophagy
JNK
Extravascular gelation shrinkage-derived internal stress enables tumor starvation therapy with suppressed metastasis and recurrence
期刊论文
NATURE COMMUNICATIONS, 2019, 卷号: 10
作者:
Zhang, Kun
;
Fang, Yan
;
He, Yaping
;
Yin, Haohao
;
Guan, Xin
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  |  
浏览/下载:110/0
  |  
提交时间:2019/12/31
Synthesis and Biological Evaluation of Five-Atom-Linker-Based Arylpiperazine Derivatives with an Atypical Antipsychotic Profile
期刊论文
CHEMMEDCHEM, 2019, 页码: 11
作者:
Wu, Chunhui
;
Wang, Yu
;
Yang, Feipu
;
Shi, Wenqiang
;
Wang, Zhen
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2020/07/01
D-2
5-HT1A
5-HT2A
serotonin
SERT
PCP-induced hyperactivity
Seven new veratramine-type alkaloids with potent analgesic effect from Veratrum taliense
期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2019, 卷号: 244, 页码: 7
作者:
Li, Qiong
;
Zhao, Yun-Li
;
Long, Cheng-Bo
;
Zhu, Pei-Feng
;
Liu, Ya-Ping
收藏
  |  
浏览/下载:90/0
  |  
提交时间:2019/11/07
V. taliense
Veratrum
Liliaceae
Veratramine-type alkaloids
Analgesic activity
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