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科研机构
上海药物研究所 [10]
生态环境研究中心 [4]
水生生物研究所 [3]
武汉大学 [2]
南海海洋研究所 [1]
大连化学物理研究所 [1]
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期刊论文 [23]
发表日期
2019 [23]
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Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives (THPBs) as proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators for the treatment of hyperlipidemia
期刊论文
ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 6, 页码: 1216-1230
作者:
Wu, Chenglin
;
Xi, Cong
;
Tong, Junhua
;
Zhao, Jing
;
Jiang, Hualiang
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2020/07/01
PCSK9
Tetrahydroprotoberberine derivatives
Low-density lipoprotein cholesterol
Lipid-lowering
PCSK9 expression
Low-density lipoprotein receptor
Total cholesterol
Hyperlipidemia hamster
Short-chain chlorinated paraffins (SCCPs) disrupt hepatic fatty acid metabolism in liver of male rat via interacting with peroxisome proliferator-activated receptor a (PPAR alpha)
期刊论文
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2019, 卷号: 181, 页码: 164-171
作者:
Gong, Yufeng
;
Zhang, Haijun
;
Geng, Ningbo
;
Ren, Xiaoqian
;
Giesy, John P.
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  |  
浏览/下载:97/0
  |  
提交时间:2019/12/02
SCCPs
Mode of action
PPAR alpha
Luciferase assay
Molecular docking
Metabolomics
Responses of pro- and anti-inflammatory cytokines in zebrafish liver exposed to sublethal doses of Aphanizomenon flosaquae DC-1 aphantoxins
期刊论文
AQUATIC TOXICOLOGY, 2019, 卷号: 215, 期号: 1, 页码: 11
作者:
Zhang, Di
;
Tang, Jing
;
Zhang, Jing
;
Zhang, De Lu
;
Hu, Chun Xiang
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  |  
浏览/下载:170/0
  |  
提交时间:2019/11/29
Aphantoxins
Zebrafish liver
Inflammation
Immunotoxicity
Response
Hepatocyte peroxisome proliferator-activated receptor alpha regulates bile acid synthesis and transport
期刊论文
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2019, 期号: 10, 页码: 1396-1411
作者:
Xie, Cen
;
Takahashi, Shogo
;
Brocker, Chad N.
;
He, Shijun
;
Chen, Li
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  |  
浏览/下载:32/0
  |  
提交时间:2020/07/01
Peroxisome proliferator-activated receptor alpha
Wy-14,643
Bile acid homeostasis
Farnesoid X receptor
Metabolomics
(5R)-5-hydroxytriptolide ameliorates liver lipid accumulation by suppressing lipid synthesis and promoting lipid oxidation in mice
期刊论文
LIFE SCIENCES, 2019, 卷号: 232, 页码: 9
作者:
Dong, Yunxia
;
Lu, Henglei
;
Li, Qiang
;
Qi, Xinming
;
Li, Yuanchao
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  |  
浏览/下载:23/0
  |  
提交时间:2020/07/01
(5R)-5-hydroxytriptolide
NAFLD
Lipid synthesis
Fatty acids oxidation
Fat deposition
Modelling liver cancer initiation with organoids derived from directly reprogrammed human hepatocytes
期刊论文
NATURE CELL BIOLOGY, 2019, 卷号: 21, 期号: 8, 页码: 1015-+
作者:
Sun, Lulu
;
Wang, Yuqing
;
Cen, Jin
;
Ma, Xiaolong
;
Cui, Lei
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  |  
浏览/下载:26/0
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提交时间:2020/07/01
Establishment of a human embryonic stem cell-based liver differentiation model for hepatotoxicity evaluations
期刊论文
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2019, 卷号: 174, 页码: 353-362
作者:
Liang, Shengxian
;
Liang, Shaojun
;
Yin, Nuoya
;
Faiola, Francesco
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  |  
浏览/下载:9/0
  |  
提交时间:2020/10/21
Thyroid hormones (THs)
Polybrominated diphenyl ethers BDE-47/209
Human embryonic stem cells (ESCs)
Developmental hepatotoxicity
Endocrine-disrupting chemicals (EDCs)
A metabolomic perspective of pazopanib-induced acute hepatotoxicity in mice
期刊论文
XENOBIOTICA, 2019, 卷号: 49, 期号: 6, 页码: 655-670
作者:
Wang, Yi-Kun
;
Yang, Xiao-Nan
;
Liang, Wei-Qing
;
Xiao, Yao
;
Zhao, Qi
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  |  
浏览/下载:65/0
  |  
提交时间:2019/07/29
Pazopanib
hepatotoxicity
metabolomics
oxidative stress
ultra-performance liquid chromatography-electrospray ion source-quadrupole
time-of-flight mass spectrometer (UPLC-ESI-QTOFMS)
Myclobutanil accumulation, transcriptional alteration, and tissue injury in lizards (Eremias argus) treated with myclobutanil enantiomers
期刊论文
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2019, 卷号: 171, 页码: 247-255
作者:
Hao, Weiyu
;
Zhang, Yanfeng
;
Xie, Yun
;
Guo, Baoyuan
;
Chang, Jing
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2020/10/23
Myclobutanil
Lizards
Enantioselective
Bioaccumulation
Gene expression
Distribution, metabolism and hepatotoxicity of neonicotinoids in small farmland lizard and their effects on GH/IGF axis
期刊论文
SCIENCE OF THE TOTAL ENVIRONMENT, 2019, 卷号: 662, 页码: 834-841
作者:
Wang, Yinghuan
;
Zhang, Yang
;
Li, Wei
;
Yang, Lu
;
Guo, Baoyuan
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2020/10/23
Attenuation
Eremias argus
Neonicotinoids
Hepatotoxicity
GH/IGF
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