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上海药物研究所 [23]
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武汉物理与数学研究所 [5]
大连化学物理研究所 [4]
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期刊论文 [66]
学位论文 [2]
发表日期
2019 [68]
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Common activation mechanism of class A GPCRs
期刊论文
ELIFE, 2019, 卷号: 8, 页码: 31
作者:
Zhou, Qingtong
;
Yang, Dehua
;
Wu, Meng
;
Guo, Yu
;
Guo, Wangjing
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浏览/下载:68/0
  |  
提交时间:2020/07/01
Discovery and biological evaluation of vinylsulfonamide derivatives as highly potent, covalent TEAD autopalmitoylation inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 184, 页码: 15
作者:
Lu, Wenchao
;
Wang, Jun
;
Li, Yong
;
Tao, Hongru
;
Xiong, Huan
收藏
  |  
浏览/下载:98/0
  |  
提交时间:2020/07/01
Hippo pathway
TEAD transcription factor
Covalent inhibitor
Palmitoylation inhibitor
Effective Virtual Screening Strategy toward heme-containing proteins: Identification of novel IDO1 inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 184, 页码: 23
作者:
Zou, Yi
;
Hu, Yue
;
Ge, Shushan
;
Zheng, Yingbo
;
Li, Yuezhen
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  |  
浏览/下载:36/0
  |  
提交时间:2020/07/01
IDO1
Heme
T cell
Cancer immunotherapy
Virtual screening
Drug design
Molecular dynamics simulation
A minimalist peptide ligand for IgG by minimizing the binding domain of protein A
期刊论文
BIOCHEMICAL ENGINEERING JOURNAL, 2019, 卷号: 151, 页码: 8
作者:
Wang, Weiying
;
Hao, Dongxia
;
Ge, Jia
;
Zhao, Lan
;
Huang, Yongdong
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  |  
浏览/下载:45/0
  |  
提交时间:2020/05/06
Affinity Purification Chromatography
Minimalist Peptide
Protein a
Igg
Rational Design
TRAIL-based gene delivery and therapeutic strategies
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 11, 页码: 1373-1385
作者:
Zhong, Hui-hai
;
Wang, Hui-yuan
;
Li, Jian
;
Huang, Yong-zhuo
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  |  
浏览/下载:116/0
  |  
提交时间:2020/07/01
TRAIL
gene delivery
gene therapy
DNA
drug delivery systems
non-viral vectors
cancer therapy
PD-L1 expression levels on tumor cells affect their immunosuppressive activity
期刊论文
ONCOLOGY LETTERS, 2019, 卷号: 18, 期号: 5, 页码: 5399-5407
作者:
Zheng, Yang
;
Fang, You-Chen
;
Li, Jing
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  |  
浏览/下载:55/0
  |  
提交时间:2020/07/01
programmed cell death 1
programmed death-ligand 1
co-culture
immunosuppression
signaling pathway
Two validated liquid chromatography-mass spectrometry methods with different pretreatments for the quantification of an anti-CD47 monoclonal antibody in rat and cynomolgus monkey serum compared with an electrochemiluminescence method
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2019, 卷号: 175, 页码: 11
作者:
Gao, Yuxiong
;
Zhang, Dan
;
Yang, Changyong
;
Duan, Xiaotao
;
Li, Xiuli
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  |  
浏览/下载:12/0
  |  
提交时间:2020/07/01
Anti-CD47 monoclonal antibody
LC-MS
Adsorption issue
Electrochemiluminescence
Pharmacokinetics
Cross-validation
Structural basis of molecular logic OR in a dual-sensor histidine kinase
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 卷号: 116, 期号: 40, 页码: 19973-19982
作者:
Shin, Heewhan
;
Ren, Zhong
;
Zeng, Xiaoli
;
Bandara, Sepalika
;
Yang, Xiaojing
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  |  
浏览/下载:165/0
  |  
提交时间:2019/11/29
photoreceptor
signal integration
phosphorylation
molecular logic
dynamic crystallography
Binding and activity of sulfated metabolites of lower-chlorinated polychlorinated biphenyls towards thyroid hormone receptor alpha
期刊论文
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2019, 卷号: 180, 页码: 686-692
作者:
Ren, Xiao-Min
;
Li, Chuan-Hai
;
Zhang, Jian-Qing
;
Guo, Liang-Hong
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2020/09/10
Lower-chlorinated polychlorinated biphenyls
LC-PCB sulfates
TR
Agonistic activity
TH system disruption effect
Exploring the Ligand Binding/Unbinding Pathway by Selectively Enhanced Sampling of Ligand in a Protein-Ligand Complex
期刊论文
JOURNAL OF PHYSICAL CHEMISTRY B, 2019, 卷号: 123, 期号: 38, 页码: 7974-7983
作者:
Shao, Qiang
;
Zhu, Weiliang
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  |  
浏览/下载:2/0
  |  
提交时间:2020/07/01
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