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浏览/检索结果: 共6条，第1-6条 帮助 限定条件 发表日期：2019     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives (THPBs) as proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators for the treatment of hyperlipidemia 期刊论文 ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 6, 页码: 1216-1230 作者:  Wu, Chenglin;  Xi, Cong;  Tong, Junhua;  Zhao, Jing;  Jiang, Hualiang 收藏  |  浏览/下载：50/0  |  提交时间：2020/07/01 PCSK9  Tetrahydroprotoberberine derivatives  Low-density lipoprotein cholesterol  Lipid-lowering  PCSK9 expression  Low-density lipoprotein receptor  Total cholesterol  Hyperlipidemia hamster   Therapeutic targets of hypercholesterolemia: HMGCR and LDLR 期刊论文 DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY, 2019, 卷号: 12, 页码: 1543-1553 作者:  Ma, Shizhan;  Sun, Wenxiu;  Gao, Ling;  Liu, Shudong 收藏  |  浏览/下载：7/0  |  提交时间：2019/12/11 cholesterol homeostasis  CVD  HMGCR  LDLR   PCSK9 Inhibitors: Novel Therapeutic Strategies for Lowering LDL-Cholesterol 期刊论文 MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2019, 卷号: 19, 期号: 2, 页码: 165-176 作者:  Wang, Yan;  Liu, Zhao-Peng 收藏  |  浏览/下载：23/0  |  提交时间：2019/12/11 Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9)  low-density lipoprotein cholesterol (LDL-C)  low-density lipoprotein  receptor (LDLR)  cardiovascular disease (CVD)  hypercholesterolemia  alirocmab  evolocumab   IDOL G51S Variant Is Associated With High Blood Cholesterol and Increases Low-Density Lipoprotein Receptor Degradation 期刊论文 2019, 页码: ATVBAHA119312589 作者:  Adi Dilare;  Lu Xiao-Yi;  Fu Zhen-Yan;  Wei Jian;  Baituola Gulinaer 收藏  |  浏览/下载：6/0  |  提交时间：2020/01/03 LDLR protein  cardiovascular disease  cholesterol  heterozygote  ubiquitination   Systematic prediction of familial hypercholesterolemia caused by low-density lipoprotein receptor missense mutations 期刊论文 2019, 卷号: 281, 页码: 1-8 作者:  Guo, Jiayan;  Gao, Yan;  Li, Xun;  He, Ying;  Zheng, Xin 收藏  |  浏览/下载：13/0  |  提交时间：2020/01/03 LDLR  Familial hypercholesterolemia  Function prediction  Missense mutation   designsynthesisandbiologicalevaluationofnoveltetrahydroprotoberberinederivativesthpbsasproproteinconvertasesubtilisinkexintype9pcsk9modulatorsforthetreatmentofhyperlipidemia 期刊论文 actapharmaceuticasinicab, 2019, 卷号: 9, 期号: 6, 页码: 1216 作者:  Wu Chenglin;  Xi Cong;  Tong Junhua;  Zhao Jing;  Jiang Hualiang 收藏  |  浏览/下载：54/0  |  提交时间：2020/07/01 DOPAMINE D-1  BERBERINE  EXPRESSION  INHIBITORS  IDENTIFICATION  CHOLESTEROL  MUTATIONS  LDLR  PCSK9  Tetrahydroprotoberberine derivatives  Low-density lipoprotein cholesterol  Lipid-lowering  PCSK9 expression  Low-density lipoprotein receptor  Total cholesterol  Hyperlipidemia hamster