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浏览/检索结果: 共23条，第1-10条 帮助 限定条件 发表日期：2019    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Common activation mechanism of class A GPCRs 期刊论文 ELIFE, 2019, 卷号: 8, 页码: 31 作者:  Zhou, Qingtong;  Yang, Dehua;  Wu, Meng;  Guo, Yu;  Guo, Wangjing 收藏  |  浏览/下载：71/0  |  提交时间：2020/07/01 Discovery and biological evaluation of vinylsulfonamide derivatives as highly potent, covalent TEAD autopalmitoylation inhibitors 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 184, 页码: 15 作者:  Lu, Wenchao;  Wang, Jun;  Li, Yong;  Tao, Hongru;  Xiong, Huan 收藏  |  浏览/下载：98/0  |  提交时间：2020/07/01 Hippo pathway  TEAD transcription factor  Covalent inhibitor  Palmitoylation inhibitor   Effective Virtual Screening Strategy toward heme-containing proteins: Identification of novel IDO1 inhibitors 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 184, 页码: 23 作者:  Zou, Yi;  Hu, Yue;  Ge, Shushan;  Zheng, Yingbo;  Li, Yuezhen 收藏  |  浏览/下载：37/0  |  提交时间：2020/07/01 IDO1  Heme  T cell  Cancer immunotherapy  Virtual screening  Drug design  Molecular dynamics simulation   TRAIL-based gene delivery and therapeutic strategies 期刊论文 ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 11, 页码: 1373-1385 作者:  Zhong, Hui-hai;  Wang, Hui-yuan;  Li, Jian;  Huang, Yong-zhuo 收藏  |  浏览/下载：119/0  |  提交时间：2020/07/01 TRAIL  gene delivery  gene therapy  DNA  drug delivery systems  non-viral vectors  cancer therapy   PD-L1 expression levels on tumor cells affect their immunosuppressive activity 期刊论文 ONCOLOGY LETTERS, 2019, 卷号: 18, 期号: 5, 页码: 5399-5407 作者:  Zheng, Yang;  Fang, You-Chen;  Li, Jing 收藏  |  浏览/下载：55/0  |  提交时间：2020/07/01 programmed cell death 1  programmed death-ligand 1  co-culture  immunosuppression  signaling pathway   Two validated liquid chromatography-mass spectrometry methods with different pretreatments for the quantification of an anti-CD47 monoclonal antibody in rat and cynomolgus monkey serum compared with an electrochemiluminescence method 期刊论文 JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2019, 卷号: 175, 页码: 11 作者:  Gao, Yuxiong;  Zhang, Dan;  Yang, Changyong;  Duan, Xiaotao;  Li, Xiuli 收藏  |  浏览/下载：12/0  |  提交时间：2020/07/01 Anti-CD47 monoclonal antibody  LC-MS  Adsorption issue  Electrochemiluminescence  Pharmacokinetics  Cross-validation   Exploring the Ligand Binding/Unbinding Pathway by Selectively Enhanced Sampling of Ligand in a Protein-Ligand Complex 期刊论文 JOURNAL OF PHYSICAL CHEMISTRY B, 2019, 卷号: 123, 期号: 38, 页码: 7974-7983 作者:  Shao, Qiang;  Zhu, Weiliang 收藏  |  浏览/下载：2/0  |  提交时间：2020/07/01 Ligand-induced activation of ERK1/2 signaling by constitutively active G(s)-coupled 5-HT receptors 期刊论文 ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 9, 页码: 1157-1167 作者:  Liu, Ping;  Yin, Yu-ling;  Wang, Ting;  Hou, Li;  Wang, Xiao-xi 收藏  |  浏览/下载：21/0  |  提交时间：2020/07/01 5-HT4R  5-HT6R  5-HT7AR  5-HT  ERK1/2  G(s)  beta-arrestin  Fyn  Src   Improving the Virtual Screening Ability of Target-Specific Scoring Functions Using Deep Learning Methods 期刊论文 FRONTIERS IN PHARMACOLOGY, 2019, 卷号: 10, 页码: 11 作者:  Wang, Dingyan;  Cui, Chen;  Ding, Xiaoyu;  Xiong, Zhaoping;  Zheng, Mingyue 收藏  |  浏览/下载：57/0  |  提交时间：2020/07/01 virtual screening  target-specific scoring function  deep learning  drug discovery  DUD-E   Underestimated Noncovalent Interactions in Protein Data Bank 期刊论文 JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2019, 卷号: 59, 期号: 8, 页码: 3389-3399 作者:  Xu, Zhijian;  Zhang, Qian;  Shi, Jiye;  Zhu, Weiliang 收藏  |  浏览/下载：6/0  |  提交时间：2020/07/01