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浏览/检索结果: 共34条，第1-10条 帮助 限定条件 发表日期：2019    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Imaging Tumorous Methylglyoxal by an Activatable Near-Infrared Fluorescent Probe for Monitoring Glyoxalase 1 Activity 期刊论文 ANALYTICAL CHEMISTRY, 2019, 卷号: 91, 期号: 24, 页码: 15577-15584 作者:  Ding, Chunyong;  Wang, Fengyang;  Dang, Yijing;  Xu, Zhiai;  Li, Lingling 收藏  |  浏览/下载：19/0  |  提交时间：2020/07/01 Design, synthesis, and biological evaluation of thieno[3,2-d]pyrimidine derivatives as potential simplified phosphatidylinositol 3-kinase alpha inhibitors 期刊论文 CHEMICAL BIOLOGY & DRUG DESIGN, 2019, 卷号: 94, 期号: 6, 页码: 2013-2022 作者:  Yang, Xiuyan;  Deng, Meng;  Zhang, Xi;  Wang, Yi;  Song, Kun 收藏  |  浏览/下载：76/0  |  提交时间：2020/07/01 PI3K alpha inhibitors  proliferation inhibition  thieno[3  2-d]pyrimidine derivatives   Synthesis and Biological Evaluation of Five-Atom-Linker-Based Arylpiperazine Derivatives with an Atypical Antipsychotic Profile 期刊论文 CHEMMEDCHEM, 2019, 页码: 11 作者:  Wu, Chunhui;  Wang, Yu;  Yang, Feipu;  Shi, Wenqiang;  Wang, Zhen 收藏  |  浏览/下载：34/0  |  提交时间：2020/07/01 D-2  5-HT1A  5-HT2A  serotonin  SERT  PCP-induced hyperactivity   Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives (THPBs) as proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators for the treatment of hyperlipidemia 期刊论文 ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 6, 页码: 1216-1230 作者:  Wu, Chenglin;  Xi, Cong;  Tong, Junhua;  Zhao, Jing;  Jiang, Hualiang 收藏  |  浏览/下载：50/0  |  提交时间：2020/07/01 PCSK9  Tetrahydroprotoberberine derivatives  Low-density lipoprotein cholesterol  Lipid-lowering  PCSK9 expression  Low-density lipoprotein receptor  Total cholesterol  Hyperlipidemia hamster   National Engineering and Technology Research Center for New drug Druggability Evaluation (Seed Program of Guangdong Province, China)[2017B090903004] 项目 项目编号: 2017B090903004, 资助机构: National Engineering and Technology Research Center for New drug Druggability Evaluation (Seed Program of Guangdong Province, China), 2019- - 收藏  |  浏览/下载：14/0  |  提交时间：2020/07/01 Current trends in drug metabolism and pharmacokinetics 期刊论文 ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 6, 页码: 1113-1144 作者:  Li, Yuhua;  Meng, Qiang;  Yang, Mengbi;  Liu, Dongyang;  Hou, Xiangyu 收藏  |  浏览/下载：37/0  |  提交时间：2020/07/01 Pharmacokinetics  Drug metabolism  Drug-drug interactions  Modeling  Metabolizing enzymes  Transporters  Nuclear receptors  Noncoding RNAs   Two validated liquid chromatography-mass spectrometry methods with different pretreatments for the quantification of an anti-CD47 monoclonal antibody in rat and cynomolgus monkey serum compared with an electrochemiluminescence method 期刊论文 JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2019, 卷号: 175, 页码: 11 作者:  Gao, Yuxiong;  Zhang, Dan;  Yang, Changyong;  Duan, Xiaotao;  Li, Xiuli 收藏  |  浏览/下载：12/0  |  提交时间：2020/07/01 Anti-CD47 monoclonal antibody  LC-MS  Adsorption issue  Electrochemiluminescence  Pharmacokinetics  Cross-validation   Design, synthesis and biological evaluation of 6-deoxy O-spiroketal C-arylglucosides as novel renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 180, 页码: 398-416 作者:  Wang, Yibing;  Lou, Yang;  Wang, Jiang;  Li, Dan;  Chen, Hui 收藏  |  浏览/下载：20/0  |  提交时间：2020/07/01 SGLT2 inhibitors  Diabetes  Sugar modification  Structure-activity relationship  Urinary glucose excretion  Oral glucose tolerance   Design, synthesis, and biological evaluation of a new class of histone acetyltransferase p300 inhibitors 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 180, 页码: 171-190 作者:  Liu, Ruiqi;  Zhang, Zhuqing;  Yang, Hong;  Zhou, Kaixin;  Geng, Meiyu 收藏  |  浏览/下载：9/0  |  提交时间：2020/07/01 p300 inhibitors  Epigenetics  Structure-activity relationship  Sensitive tumor cell proliferation  C646   Identifying the active components of Baihe-Zhimu decoction that ameliorate depressive disease by an effective integrated strategy: a systemic pharmacokinetics study combined with classical depression model tests 期刊论文 CHINESE MEDICINE, 2019, 卷号: 14, 期号: 1, 页码: 11 作者:  Zhong, Ming;  Tian, Xiaoting;  Chen, Shuoji;  Chen, Mingcang;  Guo, Ziqiong 收藏  |  浏览/下载：34/0  |  提交时间：2020/07/01 Baihe-Zhimu decoction  Antidepressant  Timosaponin BII  Timosaponin BIII  Drug discovery