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CORC

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Discovery and optimization of a series of 3-substituted indazole derivatives as multi-target kinase inhibitors for the treatment of lung squamous cell carcinoma 期刊论文
European journal of medicinal chemistry, 2018, 卷号: 163, 页码: 671-689
作者:  Wang, Qi;  Dai, Yang;  Ji, Yinchun;  Shi, Huanyu;  Guo, Zuhao
收藏  |  浏览/下载：85/0  |  提交时间：2019/01/08
Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 160, 页码: 61-81
作者:  Liu, Xuesong;  Wang, Beilei;  Chen, Cheng;  Jiang, Zongru;  Hu, Chen
收藏  |  浏览/下载：14/0  |  提交时间：2019/01/11
Design and optimization of 2,3-dihydrobenzo[b][1,4]dioxine propanoic acids as novel GPR40 agonists with improved pharmacokinetic and safety profiles 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 22, 页码: 5780-5791
作者:  Guo, Bin;  Guo, Shimeng;  Huang, Jing;  Li, Jingya;  Li, Jia
收藏  |  浏览/下载：43/0  |  提交时间：2019/01/08
Identification of a cellularly active SIRT6 allosteric activator 期刊论文
NATURE CHEMICAL BIOLOGY, 2018, 卷号: 14, 期号: 12, 页码: 1118-+
作者:  Huang, Zhimin;  Zhao, Junxing;  Deng, Wei;  Chen, Yingyi;  Shang, Jialin
收藏  |  浏览/下载：89/0  |  提交时间：2019/01/08
Adenine derivatives invert high glucose-induced thioredoxin-interacting protein overexpression 期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2018, 卷号: 92, 期号: 6, 页码: 1998-2008
作者:  Zhong, Li;  Liu, Qing;  Ting, Yan Sie;  Vun Yien Thien;  Kalong, Nurwafa Syafiqah Binti
收藏  |  浏览/下载：89/0  |  提交时间：2019/01/08
Personalized Medicines Molecular Signature-Based Drug Discovery and Development, Strategic Priority Research Program of Chinese Academy of Sciences[XDA12040307] 项目
项目编号: XDA12040307, 资助机构: Personalized Medicines Molecular Signature-Based Drug Discovery and Development, Strategic Priority Research Program of Chinese Academy of Sciences, 2018-
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收藏  |  浏览/下载：0/0  |  提交时间：2020/07/01
Personalized Medicines-Molecular Signature-based Drug Discovery and Development Strategic Priority Research Programof Chinese Academy of Sciences[XDA12020347] 项目
项目编号: XDA12020347, 资助机构: Personalized Medicines-Molecular Signature-based Drug Discovery and Development Strategic Priority Research Programof Chinese Academy of Sciences, 2018-
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收藏  |  浏览/下载：9/0  |  提交时间：2020/07/01
Personalized Medicines-Molecular Signature-based Drug Discovery and Development Strategic Priority Research Programof Chinese Academy of Sciences[XDA12040308] 项目
项目编号: XDA12040308, 资助机构: Personalized Medicines-Molecular Signature-based Drug Discovery and Development Strategic Priority Research Programof Chinese Academy of Sciences, 2018-
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收藏  |  浏览/下载：2/0  |  提交时间：2020/07/01
Structure-Based Design of 1-Heteroary1-1,3-propanediamine Derivatives as a Novel Series of CC-Chemokine Receptor 5 Antagonists 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 21, 页码: 9621-9636
作者:  Peng, Panfeng;  Chen, Huan;  Zhu, Ya;  Wang, Zhilong;  Li, Jian
收藏  |  浏览/下载：56/0  |  提交时间：2019/01/08
Development and evaluation of a novel series of Nitroxoline-derived BET inhibitors with antitumor activity in renal cell carcinoma 期刊论文
ONCOGENESIS, 2018, 卷号: 7
作者:  Chen, Wei;  Zhang, Hao;  Chen, Zhifeng;  Jiang, Hao;  Liao, Liping
收藏  |  浏览/下载：108/0  |  提交时间：2019/01/08

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