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科研机构
上海药物研究所 [19]
西北高原生物研究所 [19]
山东大学 [3]
昆明动物研究所 [3]
昆明植物研究所 [2]
四川大学 [2]
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期刊论文 [58]
发表日期
2018 [58]
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Analysis [1]
Chemistry [1]
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Discovery of new potent protein arginine methyltransferase 5 (PRMT5) inhibitors by assembly of key pharmacophores from known inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 23-24, 页码: 3693-3699
作者:
Zhu, Kongkai
;
Song, Jia-Li
;
Tao, Hong-Rui
;
Cheng, Zhi-Qiang
;
Jiang, Cheng-Shi
收藏
  |  
浏览/下载:102/0
  |  
提交时间:2019/01/08
Pharmacophore combination
Isoquinoline
PRMT5 inhibitor
Molecular docking
Molecular dynamics simulation
Modified citrus pectin inhibited bladder tumor growth through downregulation of galectin-3
期刊论文
Acta pharmacologica Sinica, 2018, 卷号: 39, 期号: 12, 页码: 1885-1893
作者:
Fang, Tian
;
Liu, Dan-Dan
;
Ning, He-Ming
;
Sun, Jing-Ya
;
Huang, Xiao-Jing
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  |  
浏览/下载:72/0
  |  
提交时间:2019/01/08
Synthesis, biological evaluation and structure-activity relationship of a novel class of PI3K alpha H1047R mutant inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 707-719
作者:
Zhang, Ning
;
Yu, Zhimei
;
Yang, Xiaohong
;
Zhou, Yan
;
Wang, Jia
收藏
  |  
浏览/下载:88/0
  |  
提交时间:2019/01/08
Anticancer drug
Phosphatidylinositol 3-kinase
Structure-activity relationship
Emodin induces apoptosis in human hepatocellular carcinoma HepaRG cells via the mitochondrial caspase‑dependent pathway
期刊论文
Oncology reports, 2018, 卷号: 40, 期号: 4, 页码: 1985-1993
作者:
Dong, Xiaoxv
;
Ni, Boran
;
Fu, Jing
;
Yin, Xingbin
;
You, Longtai
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  |  
浏览/下载:21/0
  |  
提交时间:2019/01/08
Difuran-substituted quinoxalines as a novel class of PI3K alpha H1047R mutant inhibitors: Synthesis, biological evaluation and structure activity relationship
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 157, 页码: 37-49
作者:
Zhang, Ning
;
Yu, Zhimei
;
Yang, Xiaohong
;
Zhou, Yan
;
Tang, Qing
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  |  
浏览/下载:28/0
  |  
提交时间:2019/01/08
Proliferation
Anticancer drug
Phosphatidylinositol 3-kinase inhibitor
Apoptosis
Structure-activity relationship
Polyfluorinated iodine alkanes regulated distinct breast cancer cell progression through binding with estrogen receptor alpha or beta isoforms
期刊论文
ENVIRONMENTAL POLLUTION, 2018, 卷号: 239, 页码: 300-307
作者:
Zhou, Qunfang
;
Song, Wenting
;
Liu, Qian S.
;
Sun, Zhendong
;
Yang, Xiaoxi
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/06/20
Polyfluorinated iodine alkanes
Estrogen receptor isoforms
Breast cancer cells
Cell proliferation
Cell cycle distribution
The mTOR inhibitor AZD8055 overcomes tamoxifen resistance in breast cancer cells by down-regulating HSPB8
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 8, 页码: 1338-1346
作者:
Shi, Jia-jie
;
Chen, Si-meng
;
Guo, Chen-Liang
;
Li, Yi-xue
;
Ding, Jian
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  |  
浏览/下载:22/0
  |  
提交时间:2019/01/08
tamoxifen resistance
HSPB8
AZD8055
estrogen receptor
mTOR inhibitor
Targeting the PI3K/Akt/mTOR signaling pathway by pterostilbene attenuates mantle cell lymphoma progression
期刊论文
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2018, 卷号: 50, 期号: 8, 页码: 782-792
作者:
Yu, Dandan
;
Zhang, Yong
;
Chen, Gege
;
Xie, Yongsheng
;
Xu, Zhijian
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  |  
浏览/下载:53/0
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提交时间:2019/01/08
mantle cell lymphoma
pterostilbene
antiproliferative activity
PI3K/Akt/mTOR pathway
synergistic cytotoxicity
Dihydrocelastrol exerts potent antitumor activity in mantle cell lymphoma cells via dual inhibition of mTORC1 and mTORC2
期刊论文
INTERNATIONAL JOURNAL OF ONCOLOGY, 2018, 卷号: 53, 期号: 2, 页码: 823-834
作者:
Xie, Yongsheng
;
Li, Bo
;
Bu, Wenxuan
;
Gao, Lu
;
Zhang, Yong
收藏
  |  
浏览/下载:101/0
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提交时间:2019/01/08
mantle cell lymphoma
dihydrocelastrol
apoptosis
cell cycle
mTORC1
mTORC2
Targeting AKT with Oridonin Inhibits Growth of Esophageal Squamous Cell Carcinoma In Vitro and Patient-Derived Xenografts In Vivo
期刊论文
MOLECULAR CANCER THERAPEUTICS, 2018, 卷号: 17, 期号: 7, 页码: 1540-1553
作者:
Song, Mengqiu
;
Liu, Xuejiao
;
Liu, Kangdong
;
Zhao, Ran
;
Huang, Hai
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  |  
浏览/下载:53/0
  |  
提交时间:2019/01/08
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