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浏览/检索结果: 共11条，第1-10条 帮助 限定条件 发表日期：2018     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Discovery of thiophene-containing biaryl amide derivatives as novel glucagon receptor antagonists 期刊论文 CHEMICAL BIOLOGY & DRUG DESIGN, 2018, 卷号: 92, 期号: 1, 页码: 1241-1254 作者:  Li, Jia;  Feng, Yang;  Li, Huihui;  Shu, Shuangjie;  Dai, Antao 收藏  |  浏览/下载：26/0  |  提交时间：2019/01/08 biaryl amide  glucagon receptor antagonist  molecular simulation   Bavachinin analogues as agonists of pan-peroxisome proliferator-activated receptors 期刊论文 MEDICINAL CHEMISTRY RESEARCH, 2018, 卷号: 27, 期号: 7, 页码: 1851-1862 作者:  Yi, Jingyu;  Du, Guoxin;  Zhao, Yuanyuan;  Zhang, Liuqiang;  Li, Bo 收藏  |  浏览/下载：36/0  |  提交时间：2019/01/08 Bavachinin  Metabolic syndrome  PPARs  Reporter gene assaysThese authors contributed equally: Jingyu Yi, Guoxin Du   From hit to lead: Structure-based discovery of naphthalene-1 sulfonamide derivatives as potent and selective inhibitors of fatty acid binding protein 4 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 154, 页码: 44-59 作者:  Gao, Ding-Ding;  Dou, Hui-Xia;  Su, Hai-Xia;  Zhang, Ming-Ming;  Wang, Ting 收藏  |  浏览/下载：33/0  |  提交时间：2019/01/08 FABP4 inhibitors  FABP3 sparing  Structure-based design strategy  X-ray crystallography   Discovery and structure-activity relationships study of thieno[2,3-b] pyridine analogues as hepatic gluconeogenesis inhibitors 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 152, 页码: 307-317 作者:  Ma, Fei;  Liu, Jian;  Zhou, Tingting;  Lei, Min;  Chen, Jing 收藏  |  浏览/下载：80/0  |  提交时间：2019/01/08 Thienol2,3-b]pyridine derivatives  Structure-activity relationships (SARs)  Hepatic gluconeogenesis  Type 2 diabetes mellitus (T2DM)   Linderane Suppresses Hepatic Gluconeogenesis by Inhibiting the cAMP/PKA/CREB Pathway Through Indirect Activation of PDE 3 via ERK/STAT3 期刊论文 FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9 作者:  Xie, Wei;  Ye, Yangliang;  Feng, Ying;  Xu, Tifei;  Huang, Suling 收藏  |  浏览/下载：44/0  |  提交时间：2019/01/08 cAMP  gluconeogenesis  linderane  phosphodiesterase  type 2 diabetes   Discovery of 1,8-acridinedione derivatives as novel GCN5 inhibitors via high throughput screening 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 151, 页码: 740-751 作者:  Xiong, Huan;  Han, Jie;  Wang, Jun;  Lu, Wenchao;  Wang, Chen 收藏  |  浏览/下载：30/0  |  提交时间：2019/01/08 Epigenetics  Histone acetyltransferase  GCN5  High throughput screening  1,8-Acridinedione derivative   A novel series of 4-methyl substituted pyrazole derivatives as potent glucagon receptor antagonists: Design, synthesis and evaluation of biological activities 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 8, 页码: 1896-1908 作者:  Shu, Shuangjie;  Dai, Antao;  Wang, Jiang;  Wang, Bin;  Feng, Yang 收藏  |  浏览/下载：20/0  |  提交时间：2019/01/08 Pyrazole derivatives  Glucagon receptor antagonist  Docking study  Binding pocket   Design, synthesis, and structure-activity relationships of novel 4,7,12,12a-tetrahydro-5H-thieno[3 ',2 ':3,4]pyrido[1,2-b]isoquinoline and 5,8,12,12a-tetrahydro-6H-thieno[2 ',3 ': 4,5]pyrido[2,1-a]isoquinoline derivatives as cellular activators of adenosine 5 '-monophosphate-activated protein kinase (AMPK) 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 8, 页码: 2017-2027 作者:  Gu, Zhanni;  Wu, Lingyan;  Duan, Yanan;  Wang, Jiang;  Zhou, Shengbin 收藏  |  浏览/下载：39/0  |  提交时间：2019/01/08 Adenosine 5 '-monophosphate-activated protein kinase  AMPK activators  Berberine  Tetrahydroberberine  T2DM   MicroRNA-129-5p Regulates Glycolysis and Cell Proliferation by Targeting the Glucose Transporter SLC2A3 in Gastric Cancer Cells 期刊论文 FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9 作者:  Chen, Di;  Wang, Hui;  Chen, Jie;  Li, Zhe;  Li, Shengli 收藏  |  浏览/下载：2/0  |  提交时间：2019/12/05 miR-129-5p  gastric cancer  cancer metabolism  proliferation  SLC2A3   The Effect of Chinese Medicine on Lipid and Glucose Metabolism in Acute Myocardial Infarction Through PPARγ Pathway 期刊论文 Frontiers in Pharmacology, 2018, 卷号: Vol.9 作者:  Qian Zhang;  Mingyan Shao;  Xuefeng Zhang;  Qiyan Wang;  Dongqing Guo 收藏  |  浏览/下载：7/0  |  提交时间：2019/12/26 acute  myocardial  infarction  (AMI)  Danqi  Pill  (DQP)  heart  failure  (HF)  lipid  and  glucose  metabolism  PPARγ  pathway